IP Library Granted Patent US 9,662,496
Granted Patent B2
US 9,662,496 · App. 15/058,722 · Granted May 30, 2017

Stimulation of a hypoglossal nerve for controlling the position of a patient's tongue

Inventors: Marcelo G. Lima (San Diego, CA); Paul M. Meadows (Glendale, CA); Jasper Benke (San Diego, CA)
Assignee: IMTHERA MEDICAL, INC
A61N1/3611A61N1/0551A61N1/36139A61N1/36167A61N1/0556
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Quick Facts
Patent No.
US 9,662,496
App. No.
15/058,722
Granted
May 30, 2017
Kind
B2
Abstract

A method for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's hypoglossal nerve, applying an electric signal through the electrode to the hypoglossal nerve to stimulate at least one muscle of the tongue at least until the number of obstructive sleep apnea occurrences are reduced from an initial level to a treatment level, and reducing the application of the electric signal while the number of obstructive sleep apnea occurrences remain generally at or below the treatment level.

Claims (20)

1. A method for controlling a position of a patient's tongue, the method comprising:

applying an electric signal through at least one electrode to a hypoglossal nerve to stimulate at least one muscle of the patient's tongue at least until a number of obstructive sleep apnea occurrences is reduced from an initial level to a treatment level; and

reducing the application of the electric signal in frequency, duration and/or amplitude by a predetermined amount while the number of obstructive sleep apnea occurrences remains generally at or below the treatment level.

2. The method of claim 1 , wherein reducing the application of the electric signal includes applying the electric signal having an Intra-Session Periodicity.

3. The method of claim 1 , wherein reducing the application of the electric signal includes applying the electric signal having an Inter-Session Periodicity.

4. The method of claim 1 , wherein reducing the application of the electric signal includes reducing a duration that the electric signal is applied.

5. The method of claim 1 , wherein reducing the application of the electric signal includes ceasing application of the electric signal.

6. The method of claim 1 , wherein reducing the application of the electric signal includes reducing a frequency that the electric signal is applied.

7. The method of claim 1 , wherein reducing the application of the electric signal includes reducing an amplitude that the electric signal is applied.

8. The method of claim 1 further comprises: applying an initial electric signal that gradually increases over time and then levels off.

9. The method of claim 1 , wherein the electric signal is applied to at least one targeted motor efferent of the hypoglossal nerve.

10. The method of claim 1 , wherein the electric signal is applied when the patient is asleep.

11. The method of claim 1 , wherein the electric signal is applied when the patient is awake.

12. A method for controlling a position of a patient's tongue, the method comprising:

applying an electric signal through at least one electrode to a hypoglossal nerve at a predetermined Inter-Session Periodicity to stimulate at least one muscle of the patient's tongue to reduce a number of obstructive sleep apnea occurrences.

13. A method for controlling a position of a patient's tongue, the method comprising:

applying an electric signal through at least one electrode to a hypoglossal nerve at a predetermined Intra-Session Periodicity to stimulate at least one muscle of the patient's tongue to reduce the number of obstructive sleep apnea occurrences.

14. A system for controlling a position of a patient's tongue, the system comprising: at least one electrode configured to attach to the patient's hypoglossal nerve; and an implantable pulse generator programmed to perform a method according to claim 1 .

15. A non-transitory computer readable storage medium having stored thereon computer-executable instructions which, when executed by a processor, perform a method according to claim 1 .

16. The method of claim 1 , wherein reducing the application of the electric signal is conducted independent of feedback from the patient.

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded Sep 20, 2021
From: ACF FINCO I LP
To: IMTHERA MEDICAL, INC.
Reel/Frame 057535/0850 →
SECURITY INTEREST Recorded Aug 16, 2021
From: IMTHERA MEDICAL, INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 057188/0115 →
RELEASE OF SECURITY INTEREST Recorded Aug 16, 2021
From: ARES CAPITAL CORPORATION, AS AGENT FOR THE LENDERS
To: IMTHERA MEDICAL, INC.
Reel/Frame 057188/0573 →
PATENT SECURITY AGREEMENT Recorded Dec 30, 2020
From: IMTHERA MEDICAL, INC.
To: ACF FINCO I LP, AS COLLATERAL AGENT
Reel/Frame 054881/0683 →
PATENT SECURITY AGREEMENT Recorded Jun 17, 2020
From: IMTHERA MEDICAL, INC.
To: ARES CAPITAL CORPORATION, AS COLLATERAL AGENT
Reel/Frame 052963/0651 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2016
From: LIMA, MARCELO G; MEADOWS, PAUL M; BENKE, JASPER
To: IMTHERA MEDICAL, INC
Reel/Frame 037904/0387 →
Continuity (3)
Continuation 14400733
Provisional Application 61647122 · May 15, 2012
Related Publication 20160175587A1 · Jun 23, 2016