IP Library › Granted Patent US 9,637,449
Granted Patent B2
US 9,637,449 · App. 15/061,931 · Granted May 2, 2017

Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic-acid

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Quick Facts
Patent No.
US 9,637,449
App. No.
15/061,931
Granted
May 2, 2017
Kind
B2
Abstract

Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.

Claims (4)

1. An atorvastatin 2-amino-2-methylpropan-1-ol having an x-ray powder diffraction pattern containing the following 2θ peaks measured using CuKα radiation: 4.2, 8.3, 16.0, 17.5, 18.3, 19.4, and 19.7, or a solid state 19 F nuclear magnetic resonance having the following chemical shifts measured in parts per million: −113.6 and −116.5.

2. An atorvastatin 2-amino-2-methylpropan-1-ol having an x-ray powder diffraction pattern containing the following 2θ peaks measured using CuK α radiation: 4.2, 6.0, 6.2, 8.3, 11.5, 12.5, 12.6, 16.0, 17.5, 18.3, 18.8, 19.4, 19.7, 21.3, 22.0, 22.8, 23.4, and 23.8.

3. An atorvastatin 2-amino-2-methylpropan-1-ol characterized by solid state 13 C nuclear magnetic resonance having the following chemical shifts expressed in parts per million: 179.8, 166.3, 163.3, 161.5, 161.2, 140.5, 139.5, 134.4, 132.3, 131.6, 129.8, 128.1, 126.1, 125.1, 122.2, 120.7, 116.4, 114.0, 113.4, 72.6, 71.4, 67.6, 66.3, 64.7, 64.4, 53.1, 46.9, 43.9, 43.5, 42.7, 39.7, 36.1, 26.8, 26.3, 24.3, 23.8, 23.1, 22.0, and 20.4.

4. An atorvastatin 2-amino-2-methlypropan-1-ol characterized by solid state 13 C nuclear magnetic resonance having the following chemical shifts expressed in parts per million: 179.8, 166.3, 163.3, 22.0, and 20.4.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2020
From: PFIZER INC.
To: UPJOHN US 1 LLC
Reel/Frame 054293/0154 →