Drug combinations and uses in treating a coughing condition
View Patent ↗The present specification discloses compositions comprising a plurality of therapeutic compound having antitussive activity and methods and uses for treating a coughing condition with such compositions.
1. A method of treating a coughing condition, the method comprising the step of administering a therapeutically-effective amount of the pharmaceutical composition to an individual in need thereof, the pharmaceutical composition comprising 0.5 mg/mL to 10 mg/mL of Theobromine and 0.25 mg/mL to 7.5 mg/mL of Dextromethorphan,
wherein the pharmaceutical composition does not include an anti-histamine, and
wherein administration reduces a symptom associated with the coughing condition.
2. The method according to claim 1 , wherein the composition comprises 0.5 mg/mL to 6 mg/mL of Theobromine and 0.5 mg/mL to 5 mg/mL of Dextromethorphan.
3. The method according to claim 2 , wherein the composition comprises 0.5 mg/mL to 4 mg/mL of Theobromine and 0.5 mg/mL to 3 mg/mL of Dextromethorphan.
4. The method according to claim 3 , wherein the composition comprises 1 mg/mL to 3 mg/mL of Theobromine and 1 mg/mL to 2 mg/mL of Dextromethorphan.
5. The method according to claim 4 , wherein the composition comprises 2 mg/mL of Theobromine and 1.5 mg/mL of Dextromethorphan.
6. The method according to claim 1 , wherein the therapeutically-effective amount of the pharmaceutical composition administered to the individual comprises between 10 mg/day and 250 mg/day of Theobromine and 10 mg/day and 175 mg/day of Dextromethorphan.
7. The method according to claim 6 , wherein the therapeutically-effective amount of the pharmaceutical composition administered to the individual comprises between 25 mg/day and 200 mg/day of Theobromine and 20 mg/day and 150 mg/day of Dextromethorphan.
8. The method according to claim 7 , wherein the therapeutically-effective amount of the pharmaceutical composition administered to the individual comprises between 40 mg/day and 175 mg/day of Theobromine and 30 mg/day and 120 mg/day of Dextromethorphan.
9. The method according to claim 1 , wherein the therapeutically-effective amount of the theobromine is at most 300 mg/day.
10. The method according to claim 9 , wherein the therapeutically-effective amount of the theobromine is at most 250 mg/day.
11. The method according to claim 1 , wherein the coughing condition comprises an acute coughing condition, a subacute coughing condition a chronic coughing condition.
12. The method according to claim 1 , wherein the coughing condition comprises a non- productive coughing condition or a productive coughing condition.
13. The method according to claim 1 , wherein the coughing condition comprises a cough associated with a disease or disorder.
14. The method according to claim 13 , wherein the disease or disorder is an asthma, an atopic cough, a bronchitis, a gastroesophageal reflux disease, an infection of the respiratory tract, an inflammation, a medication, a pollutant, a post-nasal drip, a smoking event, a vagal nerve irritation, a diseases of the external auditory canal, a lung disease, a lung tumor, a habit cough, a tic, a Tourette syndrome, a cardiovascular disease, or a post-infectious cough.
15. The method according to claim 14 , wherein the infection of the respiratory tract includes a cold, croup, pertussis, pneumonia, or tuberculosis.
16. The method according to claim 1 , wherein the symptom includes coughing, hoarseness, sore throat, breathing difficulty, respiratory congestion, wheezing, respiratory constriction, respiratory inflammation, muscle spasms associated with a cough, phlegm production, fainting, insomnia, vomiting, subconjunctival hemorrhage, cough defecation, cough urination, abdominal hernia, pelvic hernia, costochondritis, lower rib fracture, or any combination thereof.
17. A method of treating a coughing condition, the method comprising the step of administering a therapeutically-effective amount of the pharmaceutical composition to an individual in need thereof, the pharmaceutical composition comprising 0.5 mg/mL to 6 mg/mL of Theobromine and 0.5 mg/mL to 5 mg/mL of Dextromethorphan,
wherein the pharmaceutical composition does not include an anti-histamine, and
wherein administration reduces a symptom associated with the coughing condition.
18. A method of treating a coughing condition, the method comprising the step of administering a therapeutically-effective amount of the pharmaceutical composition to an individual in need thereof, the pharmaceutical composition comprising 0.5 mg/mL to 4 mg/mL of Theobromine and 0.5 mg/mL to 3 mg/mL of Dextromethorphan,
wherein the pharmaceutical composition does not include an anti-histamine, and
wherein administration reduces a symptom associated with the coughing condition.
19. The method according to claim 18 , wherein the composition comprises 1 mg/mL to 3 mg/mL of Theobromine and 1 mg/mL to 2 mg/mL of Dextromethorphan.