Antibacterial compounds
Disclosed are compounds of formula (I): which are of use in the treatment of bacterial diseases and infections, to compositions containing those compounds and to methods of treating bacterial diseases and infections using the compounds. In particular, the compounds are useful for the treatment of infection with, and diseases caused by, Clostridium difficile.
1. A method of treating Clostridium difficile -associated disease (CDAD) in a subject in need thereof, the CDAD selected from the group consisting of diarrhoea caused by Clostridium difficile , bloating caused by Clostridium difficile , flu-like symptoms caused by Clostridium difficile , fever caused by Clostridium difficile , appetite loss caused by Clostridium difficile , abdominal pain caused by Clostridium difficile , nausea caused by Clostridium difficile , dehydration caused by Clostridium difficile , colitis caused by Clostridium difficile and pseudomembraneous colitis caused by Clostridium difficile , which method comprises administering to said subject an effective amount of the compound 2,2′-di(pyridin-4-yl)-1H,1H-5,5′-bibenzo[d]imidazole, or a pharmaceutically acceptable N-oxide, salt, hydrate or solvate thereof.
2. The method of claim 1 , wherein the method comprises administering to said subject an effective amount of the compound 2,2′-di(pyridin-4-yl)-1H,1H-5,5′-bibenzo[d]imidazole.
3. The method of claim 1 , wherein the method comprises administering to said subject an N-oxide of the compound 2,2′-di(pyridin-4-yl)-1H,1H-5,5′-bibenzo[d]imidazole.
4. The method of claim 1 , wherein the method comprises administering to said subject a salt of the compound 2,2′-di(pyridin-4-yl)-1H,1H-5,5′-bibenzo[d]imidazole.
5. The method of claim 1 , wherein the method comprises administering to said subject a solvate of the compound 2,2′-di(pyridin-4-yl)-1H,1H-5,5′-bibenzo[d]imidazole.
6. A composition comprising an N-oxide of 2,2′-di(pyridin-4-yl)-1H,1′H-5,5′-bibenzo[d]imidazole.
7. A pharmaceutical composition comprising an antibacterial effective amount against Clostridium difficile of an N-oxide of 2,2′-di(pyridin-4-yl)-1H,1′H-5,5′-bibenzo[d]imidazole.