IP Library › Granted Patent US 9,944,752
Granted Patent B2
US 9,944,752 · App. 15/067,129 · Granted Apr 17, 2018

Block copolymers for stable micelles

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Quick Facts
Patent No.
US 9,944,752
App. No.
15/067,129
Granted
Apr 17, 2018
Kind
B2
Abstract

The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same. Compositions herein are useful for drug-delivery applications.

Claims (14)

1. A micelle comprising a triblock copolymer, wherein said micelle has a drug-loaded inner core, a crosslinked outer core, and a hydrophilic shell, wherein the triblock copolymer is of formula VII:

wherein:

n is 20-500;

m is 1 or 2;

x 1 is 1-20;

x 2 is 0-20;

y is 5 to 100;

R y is selected from one or more natural or unnatural amino acid side chain groups such that the overall block is hydrophobic;

M is a metal ion;

R T is OCH 3 ; and

wherein the drug is a molecularly targeted therapeutic.

2. The micelle according to claim 1 , wherein the drug is a tyrosine kinase inhibitor.

3. The micelle according to claim 1 , wherein the drug is:

4. The micelle according to claim 1 , wherein the drug is:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 9, 2016
From: SILL, KEVIN; VOJKOVSKY, TOMAS; CARIE, ADAM; SEMPLE, JOSEPH EDWARD; SHESHBARADARAN, HOOSHMAND
To: INTEZYNE TECHNOLOGIES, INC.
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