IP Library › Patent Application 15069258
Patent Application
App. No. 15/069,258

COSTIMULATORY B7-H1 IN RENAL CELL CARCINOMA PATIENTS: INDICATOR OF TUMOR AGGRESSIVENESS AND POTENTIAL THERAPEUTIC TARGET

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Quick Facts
Patent No.
US None
App. No.
15/069,258
Abstract

The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.

Claims (1)

1 . A method of inhibiting expression of B7-H1 in a tumor cell or a tumor-infiltrating leukocyte, the method comprising: (a) identifying a subject with cancer, the cancer comprising a target cell that expresses B7-H1, the target cell being a tumor cell or a tumor-infiltrating leukocyte; and (b) introducing into the target cell: (i) an antisense oligonucleotide that hybridizes to a B7-H1 transcript, wherein the antisense oligonucleotide inhibits expression of B7-H1 in the cell; or (ii) a B7-H1 interference RNA (RNAi).