Absorbable stent having a coating for controlling degradation of the stent and maintaining pH neutrality
View Patent ↗A biocompatible metallic material may be configured into any number of implantable medical devices, including intraluminal stents. The biocompatible metallic material may comprise a magnesium alloy. The magnesium alloy implantable medical device may be designed to degrade over a given period of time. In order to control the degradation time, the device may be coated or otherwise have affixed thereto one or more coatings, one of which comprises a material for controlling the degradation time and maintain a pH neutral environment proximate the device. Additionally, therapeutic agents may be incorporated into one or more of the coatings on the implantable medical device.
1. An intraluminal medical device comprising:
a scaffold structure formed from an amount of a biodegradable metallic material having a surface; and
at least one coating affixed directly to the surface of the scaffold structure, the at least one coating comprising a high molecular weight acid generating polymer formed from a chemical blend of a polycaprolactone having a molecular weight of at least one hundred kilodaltons and a polylactide-co-glycolide having a molecular weight of less than ten kilodaltons, the weight ratio high molecular weight polycaprolactone to low molecular weight polylactide-co-glycolide is in the range from about 5:1 to about 1:5, wherein the high molecular weight acid generating polymer and low molecular weight acid generating polymer are configured to control degradation time of the scaffold structure and local pH level and are present in amounts selected to provide a steady supply of acidic end-groups to counter balance degradation of the amount of biodegradable metallic material of the scaffold structure.
2. The intraluminal device according to claim 1 , further comprising a therapeutic agent that is released locally in therapeutically effective doses to treat a pathological condition.