IP Library › Granted Patent US 10,159,760
Granted Patent B2
US 10,159,760 · App. 15/083,424 · Granted Dec 25, 2018

HER2 binders

Inventors: Faisal Ahmed Syud (Clifton Park, NY); Brian Duh-Lan Lee (Rexford, NY); Rong Zhang (Niskayuna, NY); Peter Brian Iveson (Amersham, GB); Paul Schaffer (Vancouver, CA); Tove Simonsson (Lund, SE); Elin Gunneriusson (Saltsjobaden, SE); Fredrik Frejd (Stockholm, SE); Lars Abrahmsen (Valhallavagen, SE); Joachim Feldwisch (Tyreso, SE); Nina Herne (Stockholm, SE); Christofer Lendel (Farsta, SE)
Assignee: General Electric Company
A61K51/088C07K14/71
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Quick Facts
Patent No.
US 10,159,760
App. No.
15/083,424
Granted
Dec 25, 2018
Kind
B2
Abstract

Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

Claims (10)

1. A method of imaging at least a portion of a subject comprising:

administering a composition to the subject, wherein the composition comprises an isolated polypeptide comprising SEQ. ID No. 2 conjugated with a 99m Tc via a diaminedioxime chelator, and wherein the isolated polypeptide binds specifically to HER2; and

imaging the subject with a SPECT device.

2. The method of claim 1 , further comprising the step of:

diagnosing the subject with a HER2 expressing cancer.

3. The method of claim 2 , wherein the HER2 expressing cancer is breast cancer.

4. The method of claim 1 , wherein the diaminedioxime chelator is cPn216.

5. The method of claim 1 , wherein the 99m Tc is conjugated to the isolated polypeptide via the cPn216 chelator at the N-terminus of the isolated polypeptide.

6. The method of claim 1 , further comprising the step of:

monitoring delivery of the composition to the subject.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 29, 2016
From: SYUD, FAISAL AHMED; LEE, BRIAN DUH-LAN; ZHANG, RONG; IVESON, PETER BRIAN; SCHAFFER, PAUL; SIMONSSON, TOVE; GUNNERIUSSON, ELIN; FREJD, FREDRIK; ABRAHMSEN, LARS; FELDWISCH, JOACHIM; HERNE, NINA; LENDEL, CHRISTOFER
To: GENERAL ELECTRIC COMPANY; AFFIBODY AB
Reel/Frame 038281/0838 →
Continuity (2)
Division 12975425 · Dec 22, 2010
Related Publication 20160199521A1 · Jul 14, 2016
Cited By (1)
US 12,653,913