IP Library › Granted Patent US 9,918,984
Granted Patent B2
US 9,918,984 · App. 15/088,539 · Granted Mar 20, 2018

Methods and compositions for treating diabetes, metabolic syndrome and other conditions

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Quick Facts
Patent No.
US 9,918,984
App. No.
15/088,539
Filed
Apr 1, 2016
Granted
Mar 20, 2018
Kind
B2
Art Unit
1627
USPC
514/183
Abstract

Pharmaceuticals compositions comprising the 2S, 4R, ketoconazole enantiomer or its pharmaceutically acceptable salts, hydrates, and solvates, that are substantially free of the 2R, 4S ketoconazole enantiomer are useful to reduce cortisol synthese and for the treatment of type 2 diabetes, hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other diseases and conditions, including but not limited to Cushing's Syndrome, depression, and glaucoma.

Claims (2)

1. A method for treating Cushing's Syndrome in a patient in need of such treatment, said method comprising administering a therapeutically effective amount of 2S,4R ketoconazole enantiomer substantially free of the 2R,4S ketoconazole enantiomer to said patient.

2. The method of claim 1 , wherein the therapeutically effective amount of the 2S,4R ketoconazole enantiomer is from about 50 mg to about 600 mg.

Assignments (15)
CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICATION NO. 16/863,125 TO READ--APPLICATION NO. 62/863,125-- PREVIOUSLY RECORDED AT REEL: 057702 FRAME: 0311. ASSIGNOR(S) HEREBY CONFIRMS THE RELEASE OF SECURITY AGREEMENT. Recorded Jul 25, 2023
From: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
To: STRONGBRIDGE DUBLIN LIMITED
Reel/Frame 064444/0038 →
CORRECTIVE ASSIGNMENT TO CORRECT THE APPLICATION NUMBER PREVIOUSLY RECORDED AT REEL: 052705 FRAME: 0039. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST. Recorded Jul 21, 2023
From: STRONGBRIDGE DUBLIN LIMITED
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
Reel/Frame 064357/0750 →
SECURITY INTEREST Recorded Mar 9, 2022
From: XERIS PHARMACEUTICALS, INC.; STRONGBRIDGE DUBLIN LIMITED
To: HAYFIN SERVICES LLP
Reel/Frame 059552/0066 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 18, 2022
From: STRONGBRIDGE DUBLIN LIMITED
To: XERIS PHARMACEUTICALS, INC.
Reel/Frame 059052/0695 →
RELEASE OF SECURITY INTEREST Recorded Oct 5, 2021
From: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
To: STRONGBRIDGE DUBLIN LIMITED
Reel/Frame 057702/0311 →
SECURITY INTEREST Recorded May 19, 2020
From: STRONGBRIDGE DUBLIN LIMITED
To: AVENUE VENTURE OPPORTUNITIES FUND, L.P.
Reel/Frame 052705/0039 →
RELEASE OF SECURITY INTEREST Recorded Dec 18, 2018
From: CRG SERVICING LLC, AS ADMINISTRATIVE AGENT
To: STRONGBRIDGE IRELAND LIMITED
Reel/Frame 047804/0978 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 18, 2018
From: STRONGBRIDGE IRELAND LIMITED
To: STRONGBRIDGE DUBLIN LIMITED
Reel/Frame 047805/0190 →
RELEASE OF SECURITY INTEREST Recorded Dec 18, 2018
From: CRG SERVICING LLC, AS ADMINISTRATIVE AGENT
To: CORTENDO AB (PUBL)
Reel/Frame 047804/0901 →
SECURITY INTEREST Recorded Apr 2, 2018
From: STRONGBRIDGE IRELAND LIMITED
To: CRG SERVICING LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 045414/0907 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2018
From: CORTENDO AB (PUBL)
To: STRONGBRIDGE IRELAND LIMITED
Reel/Frame 045409/0675 →
CHANGE OF NAME Recorded Mar 23, 2018
From: CORTENDO INVEST AB (PUBL)
To: CORTENDO AB (PUBL)
Reel/Frame 045689/0196 →
RELEASE OF SECURITY INTEREST Recorded Jul 14, 2017
From: OXFORD FINANCE LLC, IN ITS CAPACITY AS COLLATERAL AGENT AND AS LENDER
To: CORTENDO AB (PUBL)
Reel/Frame 043012/0062 →
SECURITY INTEREST Recorded Jul 14, 2017
From: CORTENDO AB (PUBL)
To: CRG SERVICING LLC, AS ADMINISTRATIVE AGENT
Reel/Frame 043012/0145 →
SECURITY INTEREST Recorded Dec 29, 2016
From: CORTENDO AB (PUBL)
To: OXFORD FINANCE LLC, AS COLLATERAL AGENT AND LENDER
Reel/Frame 040807/0199 →