Silicone scar treatment preparation
Disclosed is 1) a method for greatly increasing the solubility of useful actives in siloxane matrix-forming preparations, and 2) the associated preparations, themselves. Volatilizing coagents are utilized to give novel gels containing heretofore siloxane-insoluble additives.
1. A composition for topical application, the composition consisting essentially of:
(a) a volatile component having a cyclic siloxane and being present in the composition at a concentration ranging from 12 wt % to 45 wt % of the overall composition;
(b) siloxane matrix precursors at a concentration ranging from 25 wt % to 60 wt % of the overall composition that are capable of polymerization during topical application to form a siloxane matrix;
(c) an active component solubilized in the composition; and
(d) a volatile coagent being present in the composition at a concentration ranging from 5 wt % to 50 wt % of the overall composition and including at least one selected from the group consisting of dimethyl isosorbide, pentylene glycol, and isopropyl myristate, wherein:
the active component is a corticosteroid ranging from 0.5 wt % to 3 wt %.
2. The composition of claim 1 , wherein the volatile component comprises cyclopentasiloxane.
3. The composition of claim 1 , wherein the silioxane matrix precursors comprise dimethicone and dimethicone crosspolymer.
4. The composition of claim 1 , wherein the siloxane matrix precursors comprise dimethicone crosspolymer and fumed silica.
5. The composition of claim 1 , wherein the siloxane matrix precursors comprise dimethicone, dimethicone crosspolymer, and fumed silica.
6. The composition of claim 5 , wherein the corticosteroid is hydrocortisone or a salt thereof at a concentration ranging from 0.5 wt % to 3 wt % of the overall composition.
7. The composition of claim 6 , wherein the volatile coagent comprises 10 wt % to 25 wt % of the overall composition.
8. The composition of claim 7 , wherein the volatile component is cyclopentasiloxane.
9. The composition of claim 1 , wherein the corticosteroid is hydrocortisone or a salt thereof at a concentration ranging from 0.5 wt % to 1 wt % of the overall composition.
10. The composition of claim 9 , wherein the volatile coagent comprises 10 wt % to 25 wt % of the overall composition.
11. The composition of claim 10 , wherein the volatile component is cyclopentasiloxane.
12. A composition for topical application, the composition consisting essentially of:
(a) a volatile component having a cyclic siloxane and being present in the composition at a concentration ranging from 12 wt % to 45 wt % of the overall composition;
(b) siloxane matrix precursors at a concentration ranging from 25 wt % to 60 wt % of the overall composition that are capable of polymerization during topical application to form a siloxane matrix;
(c) an active component solubilized in the composition; and
(d) a volatile coagent being present in the composition at a concentration ranging from 5 wt % to 50 wt % of the overall composition and including at least one selected from the group consisting of dimethyl isosorbide, pentylene glycol, and isopropyl myristate, wherein:
the active component includes an agent having sun screening activity.
13. The composition of claim 12 , wherein the agent having sun screening activity comprises octinoxate and octisalate.
14. The composition of claim 13 , wherein the agent having sun screening activity further comprises at least one of octocrylene and oxybenzone.
15. The composition of claim 14 , wherein the agent having sun screening activity further comprises octocrylene and oxybenzone.
16. The composition of claim 12 , wherein the volatile component comprises cyclopentasiloxane.
17. The composition of claim 12 , wherein the silioxane matrix precursors comprise dimethicone and dimethicone crosspolymer.
18. The composition of claim 12 , wherein the siloxane matrix precursors comprise dimethicone crosspolymer and fumed silica.
19. The composition of claim 12 , wherein the siloxane matrix precursors comprise dimethicone, dimethicone crosspolymer, and fumed silica.
20. The composition of claim 19 , wherein the agent having sun screening activity comprises octinoxate and octisalate.
21. The composition of claim 20 , wherein the volatile coagent comprises 10 wt % to 25 wt % of the overall composition.
22. The composition of claim 21 , wherein the volatile component is cyclopentasiloxane.