Clay-based hemostatic agents
View Patent ↗A hemostatic device for promoting the clotting of blood includes a gauze substrate, a clay material disposed on the gauze substrate, and also a polyol such as glycerol or the like disposed on the gauze substrate to bind the clay material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood emanating from the wound to cause the clotting. A bandage that can be applied to a bleeding wound to promote the clotting of blood includes a flexible substrate and a gauze substrate mounted thereon. The gauze substrate includes a clay material and a polyol. A hemostatic sponge also includes a gauze substrate and a dispersion of hemostatic material and a polyol on a first surface of the substrate.
1. A hemostatic device for promoting the clotting of blood, the device comprising:
a substrate;
a clay material disposed on a surface of the substrate and distinct from the substrate;
a binder that is distinct from the substrate and the clay, that adheres at least a portion of the clay material to the surface of the substrate so that the surface is substantially free of loose clay;
wherein the binder comprises one or more of chitosan, guar gum, a gelatinized starch, a polysaccharide, a cellulose, and calcium alginate;
wherein the clay material is positioned on the surface of the device in a region configured to contact blood from a bleeding wound, thereby promoting clotting.
2. The device of claim 1 , wherein the binder comprises a gelatinized starch.
3. The device of claim 1 , wherein the binder comprises calcium alginate.
4. The device of claim 1 , wherein the binder comprises a polysaccharide.
5. The device of claim 1 , wherein the binder comprises a cellulose.
6. The device of claim 1 , wherein the clay material is selected from the group consisting of attapulgite, bentonite, kaolin, diatomaceous earth, and combinations of the foregoing materials.
7. The device of claim 1 , wherein the clay comprises kaolin.
8. The device of claim 1 , wherein the substrate is flexible to allow the substrate to form to a shape of the bleeding wound and to retrain a shape of the bleeding wound.
9. The device of claim 1 , wherein the substrate is gauze.
10. The device of claim 1 , wherein at least one of an antibiotic, an antifungal agent, an anti-microbial agent, a silver ions, or copper ions is mixed with, associated with, or incorporated into the clay material.
11. The device of claim 1 , further comprising a release agent.
12. A hemostatic device for promoting the clotting of blood, the device comprising:
an absorbent substrate;
a clay material disposed on the surface of the substrate material and initially separate from the substrate material;
a binder comprising an alginate that is distinct from the substrate material and the clay, that adheres at least a portion of the clay material to the surface of the substrate material so that the surface is substantially free of loose clay;
wherein the clay material is positioned on the surface of the device in a region configured to contact blood from a bleeding wound, thereby promoting clotting.
13. The device of claim 12 , wherein the absorbent substrate is gauze.
14. The device of claim 12 , wherein the clay comprises kaolin.
15. The device of claim 12 , wherein the substrate is flexible to allow the substrate to form to a shape of the bleeding wound and to retrain a shape of the bleeding wound.
16. The device of claim 12 , wherein at least one of an antibiotic, an antifungal agent, an anti-microbial agent, a silver ions, or copper ions is mixed with, associated with, or incorporated into the clay material.
17. The device of claim 12 , further comprising a release agent.
18. The device of claim 17 , wherein the release agent is selected from the group consisting of polyvinyl alcohol, glycerol, carboxymethyl cellulose, silicone, and gelatinized starch.
19. A hemostatic device for promoting the clotting of blood, the device comprising:
an absorbent substrate;
a clay material disposed on the surface of the substrate material;
a binder comprising a cellulose that is distinct from the substrate material and the clay, that adheres at least a portion of the clay material to the surface of the substrate material so that the surface is substantially free of loose clay;
wherein the absorbent substrate initially exists separately from the clay material;
wherein the clay material is positioned on the surface of the device in a region configured to contact blood from a bleeding wound, thereby promoting clotting.
20. The device of claim 19 , wherein the clay material comprises kaolin.