IP Library Granted Patent US 9,915,642
Granted Patent B2
US 9,915,642 · App. 15/090,981 · Granted Mar 13, 2018

Method for assessing the condition of a tissue sample with coherent electromagnetic radiation

Inventor: David Ribble (Indianapolis, IN)
Assignee: Hill-Rom Services, Inc
G01N33/4833A61B5/0066A61B5/445G01B9/02088G01B9/02091G01N21/47G01N21/4795G01N2201/068G01N2201/06113
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Quick Facts
Patent No.
US 9,915,642
App. No.
15/090,981
Granted
Mar 13, 2018
Kind
B2
Abstract

A method of assessing a tissue sample includes the steps of: 1) splitting source electromagnetic radiation into: a) sample arm radiation directed in a Z direction toward a sample thereby illuminating the sample at a first selected XY coordinate pair of the sample, and b) reflector arm radiation directed toward a reflector so that the reflector arm radiation travels a path length; 2) interfering sample-scattered electromagnetic radiation with reflector-reflected electromagnetic radiation thereby establishing an interference pattern associated with the sample; 3) comparing the sample interference pattern to a reference interference pattern; and 4) reaching a conclusion about the sample based on the comparison.

Claims (18)

1. A method of assessing a tissue sample comprising:

splitting source electromagnetic radiation into:

a) sample arm radiation directed in a Z direction toward an in-situ tissue sample whose condition is sought thereby illuminating the sample at a first selected XY coordinate pair of the sample, and

b) reflector arm radiation directed toward a reflector so that the reflector arm radiation travels a path length;

interfering sample-scattered electromagnetic radiation with reflector-reflected electromagnetic radiation thereby establishing an interference pattern associated with the in-situ sample;

generating a reference interference pattern or patterns, each generated interference pattern being associated with an in-situ referee tissue sample whose condition with respect to a condition of interest is known or believed; comparing the sample interference pattern to the generated reference interference pattern; and

reaching a conclusion about the sample based on the comparison; wherein the tissue sample whose condition is sought is at a target site and the referee tissue sample is at one or more sister sites the target site being the sacrum and the sister site being the gluteus, offset laterally from the sacrum, or the sternum.

2. The method of claim 1 comprising two or more of the establishing steps, the establishing steps being carried out for different path lengths, and wherein the reference interference pattern is a pattern array, and wherein the comparing step comprises comparing sample interference patterns arising from the two or more establishing steps to members of the reference interference pattern array.

3. The method of claim 2 wherein the two or more establishing steps are carried out at one or more additional XY coordinate pairs different from the first XY coordinate pair.

4. The method of claim 2 wherein the comparing step treats the sample interference patterns as an aggregate and compares the aggregate to the reference interference pattern array as a whole.

5. The method of claim 2 wherein the comparing step treats the sample interference patterns individually and compares the individual patterns to members of the reference interference pattern array taken individually.

6. The method of claim 1 comprising two or more of the establishing steps, the establishing steps being carried out for substantially equal path lengths at one or more additional XY coordinate pairs different from the first XY coordinate pair, and wherein the reference interference pattern is a pattern array, and wherein the comparing step comprises comparing sample interference patterns arising from the two or more establishing steps to the reference interference pattern array.

7. The method of claim 6 wherein the two or more establishing steps are carried out for different path lengths.

8. The method of claim 6 wherein the comparing step treats the sample interference patterns as an aggregate and compares the aggregate to the reference interference pattern array as a whole.

9. The method of claim 6 wherein the comparing step treats the sample interference patterns individually and compares the individual patterns to members of the reference interference pattern array taken individually.

10. The method of claim 1 wherein the conclusion is whether or not a pressure ulcer or a condition consistent with an incipient pressure ulcer is present in the sample.

11. The method of claim 1 wherein the source electromagnetic radiation is selected from a portion of the electromagnetic spectrum which encompasses infrared, visible and ultraviolet wavelengths.

12. The method of claim 1 wherein the coherent electromagnetic radiation is low coherence electromagnetic radiation.

Assignments (5)
RELEASE OF SECURITY INTEREST AT REEL/FRAME 050260/0644 Recorded Dec 14, 2021
From: JPMORGAN CHASE BANK, N.A.
To: BREATHE TECHNOLOGIES, INC.; HILL-ROM SERVICES, INC.; ALLEN MEDICAL SYSTEMS, INC.; WELCH ALLYN, INC.; HILL-ROM, INC.; VOALTE, INC.; BARDY DIAGNOSTICS, INC.; HILL-ROM HOLDINGS, INC.
Reel/Frame 058517/0001 →
SECURITY AGREEMENT Recorded Sep 4, 2019
From: HILL-ROM HOLDINGS, INC.; HILL-ROM, INC.; HILL-ROM SERVICES, INC.; ALLEN MEDICAL SYSTEMS, INC.; ANODYNE MEDICAL DEVICE, INC.; VOALTE, INC.; WELCH ALLYN, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 050260/0644 →
RELEASE OF SECURITY INTEREST Recorded Sep 3, 2019
From: JPMORGAN CHASE BANK, N.A.
To: HILL-ROM SERVICES, INC.; ALLEN MEDICAL SYSTEMS, INC.; WELCH ALLYN, INC.; HILL-ROM COMPANY, INC.; HILL-ROM, INC.; ANODYNE MEDICAL DEVICE, INC.; MORTARA INSTRUMENT, INC.; MORTARA INSTRUMENT SERVICES, INC.; VOALTE, INC.
Reel/Frame 050254/0513 →
SECURITY AGREEMENT Recorded Sep 26, 2016
From: HILL-ROM SERVICES, INC.; ASPEN SURGICAL PRODUCTS, INC.; ALLEN MEDICAL SYSTEMS, INC.; WELCH ALLYN, INC.
To: JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT
Reel/Frame 040145/0445 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2016
From: FU, YONGJI; AGDEPPA, ERIC D.; RIBBLE, DAVID
To: HILL-ROM SERVICES, INC.
Reel/Frame 038456/0357 →
Continuity (3)
Provisional Application 62146607 · Apr 13, 2015
Provisional Application 62153134 · Apr 27, 2015
Related Publication 20160299121A1 · Oct 13, 2016