Granted Patent
B2
US 9,873,688 · App. 15/093,486 · Granted Jan 23, 2018
Process for the synthesis of an indoleamine 2,3-dioxygenase inhibitor
Inventors:
Ming Tao (Maple Glen, PA); William Frietze (Kennett Square, PA); David J. Meloni (Bear, DE); Lingkai Weng (Malvern, PA); Jiacheng Zhou (Newark, DE); Yongchun Pan (Wilmington, DE)
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Abstract
The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.
Claims (7)
1. A compound of Formula F18:
wherein R 4 is benzyl, ethyl, C 1-3 haloalkyl, 2,2,2-trichloroethyl or 9H-fluoren-9-ylmethyl.
2. The compound of claim 1 , wherein R 4 is benzyl.
3. The compound of claim 1 , wherein R 4 is ethyl.
4. The compound of claim 1 , wherein R 4 is C 1-3 haloalkyl.
5. The compound of claim 1 , wherein R 4 is 2,2,2-trichloro ethyl.
6. The compound of claim 1 , wherein R 4 is 9H-fluoren-9-ylmethyl.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 29, 2016
From: TAO, MING; FRIETZE, WILLIAM; MELONI, DAVID J.; WENG, LINGKAI; ZHOU, JIACHENG; PAN, YONGCHUN
To: INCYTE CORPORATION
Reel/Frame 039044/0259 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 29, 2016
From: INCYTE CORPORATION
To: INCYTE HOLDINGS CORPORATION; INCYTE CORPORATION
Reel/Frame 039044/0308 →
Continuity (3)
Provisional Application
61901689
· Nov 8, 2013