4-hydroxybutyric acid analogs
This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.
1. A pharmaceutical composition comprising an effective amount of a compound of formula IV-a:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, wherein each position designated as deuterium has a deuterium incorporation of at least 75%.
2. The pharmaceutical composition of claim 1 , additionally comprising a second therapeutic agent which is a dual serotonin-norepinephrine reuptake inhibitor or an alpha2-delta subunit calcium channel modulator.
3. The pharmaceutical composition of claim 2 , wherein the second therapeutic agent is duloxetine, milnacipran, venlafaxine, pregabalin, gabapentin, or a prodrug thereof.
4. The pharmaceutical composition of claim 1 , wherein each position designated as deuterium has a deuterium incorporation of at least 82.5%.
5. The pharmaceutical composition of claim 1 , wherein each position designated as deuterium has a deuterium incorporation of at least 90%.
6. The pharmaceutical composition of claim 1 , wherein each position designated as deuterium has a deuterium incorporation of at least 95%.
7. The pharmaceutical composition of claim 1 , wherein each position designated as deuterium has a deuterium incorporation of at least 97%.
8. A method of treating a disease or disorder selected from narcolepsy, excessive daytime sleepiness (EDS), or cataplexy, comprising the step of administering to a patient in need thereof an effective amount of a composition of claim 1 .
9. The method of claim 8 , wherein the disease or disorder is narcolepsy with cataplexy.
10. The method of claim 8 , wherein each position designated as deuterium has a deuterium incorporation of at least 82.5%.
11. The method of claim 8 , wherein each position designated as deuterium has a deuterium incorporation of at least 90%.
12. The method of claim 8 , wherein each position designated as deuterium has a deuterium incorporation of at least 95%.
13. The method of claim 8 , wherein each position designated as deuterium has a deuterium incorporation of at least 97%.