Continuous monitoring of tumor hypoxia using near-infrared spectroscopy and tomography with a photonic mixer device
View Patent ↗A device and a method to measure the concentrations of oxygenated and deoxygenated hemoglobin in tissue around a tumor via near-infrared (NIR) spectroscopy with a photonic mixer device (PMD) is described.
1. A device for continuous monitoring of a tumor in a tissue region, the device comprising:
a PMD camera chip; and
at least two amplitude modulated near-infrared light sources horizontally separated from the PMD camera chip such that the PMD camera chip and the at least two near-infrared light sources are in a reflection geometry,
wherein a first amplitude modulated near-infrared light source emits near-infrared light at a first wavelength, the first wavelength below an isosbestic point of hemoglobin, and
wherein a second amplitude modulated near-infrared light source emits near-infrared light at a second wavelength, the second wavelength above the isosbestic point of hemoglobin.
2. The device of claim 1 , wherein the PMD camera chip is a multi-pixel PMD camera chip.
3. The device of claim 1 , wherein the at least two modulated near-infrared light sources are included in an array of modulated near-infrared light sources arranged around the PMD camera chip.
4. The device of claim 1 , wherein each of the at least two modulated near-infrared light sources is modulated at different frequencies.
5. The device of claim 1 , further comprising a motor to move the at least two modulated near-infrared light sources around the PMD camera chip.
6. The device of claim 1 , further comprising a wireless communication system to transmit recorded data to a remote processing unit or a cloud server.
7. The device of claim 1 , further comprising a wireless power system.
8. The device of claim 1 , wherein a distance between the modulated near-infrared light sources and the PMD camera chip is approximately twice the depth of the tumor from the surface of the tissue region.