Long-acting ketoprofen compositions
The invention describes a long-acting veterinary composition comprising at least one ketoprofen ester prodrug. The composition also comprises at least one veterinary acceptable triglyceride, and optionally, at least one preservative, and optionally, at least one additional veterinary acceptable excipient. The invention also describes a method of treating an animal for fever, pain, and/or inflammation by administering the long-acting composition comprising at least one ketoprofen ester prodrug to the animal in need thereof.
1. An injectable veterinary long-acting composition comprising
a) a ketoprofen methyl ester prodrug in the amount of about 20-300 mg/mL; b) a veterinary acceptable triglyceride that is a caprylic/capric acid triglyceride;
c) at least one preservative, and
d) a veterinary acceptable excipient that is a solvent selected from the group consisting of benzyl benzoate, polyethylene glycol, N,N-dimethylyacetamide, propylene glycol, ethanol, benzyl alcohol, dimethyl sulfoxide, N-methylpyrrolidone, 2-pyrrolidone, glycerol formal, glycerol, isopropyl myristate, tetraglycol, diethylene glycol monoethyl ether and diethylene glycol monomethyl ether; and wherein said composition provides for the treatment of pain, inflammation, and/or fever reduction for up to 120 hours following a single injectable dose.
2. The veterinary long-acting composition of claim 1 wherein the veterinary acceptable solvent is benzyl benzoate.
3. The veterinary long-acting composition of claim 2 wherein the veterinary acceptable caprylic/capric triglyceride is Miglyol 812.
4. The veterinary long-acting composition of claim 1 wherein the at least one preservative is benzyl alcohol.