Hydrous adhesive patch
View Patent ↗Provided is a patch providing sufficiently high absorbability of dexmedetomidine and less skin irritation. Hydrous adhesive patch comprising dexmedetomidine or a salt thereof and a water-soluble polymer.
1. A hydrous adhesive patch, comprising:
an adhesive gel base comprising dexmedetomidine or a salt thereof, a water-soluble polymer, a glycol, a fatty acid ester selected from the group consisting of a higher fatty acid alkyl ester, a polyhydric alcohol fatty acid ester, and a combination thereof, and water,
wherein a content of the water in the adhesive gel base is 25 to 70 mass %.
2. The hydrous adhesive patch of claim 1 , wherein a content of the water-soluble polymer in the adhesive gel base is 5 to 25 mass %.
3. The hydrous adhesive patch of claim 1 , wherein the water-soluble polymer comprises a polyacrylic acid or a salt thereof and carboxymethylcellulose or a salt thereof.
4. The hydrous adhesive patch of claim 1 , wherein the adhesive gel base has a pH of 6 to 7.
5. The hydrous adhesive patch of claim 1 , wherein the glycol is propylene glycol.
6. The hydrous adhesive patch of claim 1 , wherein the fatty acid ester is at least one of a C8-C24 fatty acid C1-C6 alkyl ester and a polyhydric alcohol C8-C24 fatty acid ester.
7. The hydrous adhesive patch of claim 1 , wherein the fatty acid ester is at least one of isopropyl myristate and propylene glycol monocaprylate.
8. The hydrous adhesive patch of claim 1 , wherein the fatty acid ester is C8-C24 fatty acid C1-C6 alkyl ester.
9. The hydrous adhesive patch of claim 1 , wherein the fatty acid ester is isopropyl myristate.
10. The hydrous adhesive patch of claim 1 , wherein a content of the glycol in the adhesive gel base is 10 to 60 mass %, and a content of the fatty acid ester in the adhesive gel base is 0.01 to 15 mass %.
11. The hydrous adhesive patch of claim 1 , wherein the adhesive gel base is a sedative.
12. The hydrous adhesive patch of claim 2 , wherein the water-soluble polymer comprises a polyacrylic acid or a salt thereof and carboxymethylcellulose or a salt thereof.
13. The hydrous adhesive patch of claim 2 , wherein the adhesive gel base has a pH of 6 to 7.
14. The hydrous adhesive patch of claim 1 , wherein the glycol is propylene glycol, and the fatty acid ester is at least one of a C8-C24 fatty acid C1-C6 alkyl ester and a polyhydric alcohol C8-C24 fatty acid ester.
15. The hydrous adhesive patch of claim 1 , wherein the glycol is propylene glycol, and the fatty acid ester is at least one of isopropyl myristate and propylene glycol monocaprylate.
16. The hydrous adhesive patch of claim 1 , wherein the glycol is propylene glycol, and the fatty acid ester is isopropyl myristate.
17. The hydrous adhesive patch of claim 15 , wherein a content of the glycol in the adhesive gel base is 10 to 60 mass %, and a content of the fatty acid ester in the adhesive gel base is 0.01 to 15 mass %.
18. The hydrous adhesive patch of claim 16 , wherein a content of the glycol in the adhesive gel base is 10 to 60 mass %, and a content of the fatty acid ester in the adhesive gel base is 0.01 to 15 mass %.
19. The hydrous adhesive patch of claim 1 , further comprising:
a backing layer on which the adhesive gel base is applied; and
a covering film covering the adhesive gel base applied on the backing layer.
20. The hydrous adhesive patch of claim 1 , wherein the fatty acid ester is a higher fatty acid alkyl ester.
21. The hydrous adhesive patch of claim 1 , wherein the fatty acid ester comprises a higher fatty acid alkyl ester and a polyhydric alcohol fatty acid ester.