Whole blood separation sampling apparatus

1. A method of separating non-cellular components of a sample of blood from the cellular components of the sample of blood, the method comprising the steps of:

providing a sampling membrane configured to receive and contain the sample of blood, the sampling membrane configured to retard a movement of the cellular components relative to a movement of the non-cellular components; and

applying the sample of blood to a central portion of the sampling membrane such that the sampling membrane retards the movement of the cellular components relative to the movement of the non-cellular components and includes, after a predefined period of time from receiving the blood, a plurality of testing sites that each provide different concentrations of the cellular components and the non-cellular components.

2. The method of claim 1 , wherein the sampling membrane is configured to receive and contain a fixed volume of the sample of blood.

3. The method of claim 1 , wherein the sampling membrane is disposable within a cartridge having an interior chamber that is configured to house the sampling membrane.

4. A device for separating non-cellular components of a sample of blood from cellular components of the sample of blood, the device comprising:

a sampling membrane configured to receive and contain the sample of blood, the sampling membrane configured to retard a movement of the cellular components relative to a movement of the non-cellular components such that the sampling membrane, after a predefined period of time from receiving the sample of blood, includes a plurality of testing sites that each provide different concentrations of the cellular components and the non-cellular components.

5. The device of claim 4 , wherein the sampling membrane is configured to receive and contain a fixed volume of the sample of blood.

6. The device of claim 4 , further comprising a drying agent disposable beneath the sampling membrane, the drying agent configured to remove moisture from the sample of blood after the sampling membrane receives the sample of blood.

7. The device of claim 6 , further comprising a mesh-like barrier disposable between the sampling membrane and the drying agent, the mesh-like barrier configured to separate the sampling membrane from the drying agent.

8. The device of claim 7 , further comprising a barrier disposable between the mesh-like barrier and the drying agent, the barrier configured to control a rate of moisture being removed by the drying agent from the sample of blood.

9. The device of claim 4 , further comprising a cartridge having an interior chamber configured to house the sampling membrane.

10. The device of claim 4 , wherein the sampling membrane is formed of at least one of the following: nylon, polypropylene, polyester, rayon, cellulose, cellulose acetate, nitrocellulose, mixed cellulose ester, glass microfiber filters, cotton, quartz microfiber, polytetrafluoroethylene, or polyvinylidene fluoride.

11. The device of claim 4 , wherein the sampling membrane is formed of a material that has been chemically treated to assist with at least one of the following: sample retention, test preparation, or increased sample longevity.

12. The device of claim 4 , wherein the sampling membrane is perforated such that the sampling membrane can be readily separated into one or more portions.

13. The device of claim 4 , wherein the sampling membrane includes:

a center portion with a diameter of approximately 12-14 millimeters (mm); and

a spiral arm with a maximum width of approximately 8 mm, the spiral arm having a first end connected to the center portion and a tapering portion that extends around a portion of a perimeter of the center portion and tapering to a second end of the spiral arm.

14. The device of claim 4 , further comprising a moisture-tight cartridge having an interior chamber configured to house the sampling membrane, the moisture-tight cartridge configured to provide a moisture-tight barrier between the sampling membrane and an external environment.

15. The device of claim 4 , wherein the plurality of testing sites includes:

a first testing site located on a center portion of the sampling membrane, the first testing site including a first concentration of the cellular components and a first concentration of the non-cellular components; and

a second testing site located a first distance along a spiral arm of the sampling membrane, the second testing site including a second concentration of the cellular components that is less than the first concentration of the cellular components and a second concentration of the non-cellular components that is greater than the first concentration of the non-cellular components.

16. The device of claim 15 , wherein the plurality of testing sites further includes a third testing site located a second distance along the spiral arm that is greater than the first distance, the third testing site including:

a third concentration of the cellular components that is less than the first concentration of the cellular components and the second concentration of the cellular components; and

a third concentration of the non-cellular components that is greater than the first concentration of the non-cellular components and the second concentration of the non-cellular components.

17. The device of claim 7 , further comprising an applicator including a center opening, the applicator disposable over the sampling membrane such that a center portion of the sampling membrane is exposed for receiving the sample of blood, the applicator having an outer diameter greater than the outer diameter of the sampling membrane.

18. The device of claim 4 , wherein the cellular components include at least one of red blood cells or white blood cells, and the non-cellular components include at least one of plasma or serum.

19. The device of claim 4 , wherein the sampling membrane is spiral-shaped.

20. A system, comprising:

the device of claim 4 ; and

a puncturing mechanism configured to puncture a skin of a subject to provide access to the sample of blood for being received on the sampling membrane.