IP Library Granted Patent US 9,814,831
Granted Patent B2
US 9,814,831 · App. 15/106,853 · Granted Nov 14, 2017

Moving basal engine for a fluid delivery device

Inventor: Robert R. Gonnelli (Mahwah, NJ)
Assignee: VALERITAS, INC.
A61M5/1454A61M5/1452A61M5/14248A61M5/14526A61M5/3159A61M5/31526A61M5/31533A61M5/31578A61M5/14244A61M2005/1405A61M2005/14204A61M2005/14506A61M2005/14513
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Quick Facts
Patent No.
US 9,814,831
App. No.
15/106,853
Granted
Nov 14, 2017
Kind
B2
Abstract

A fluid delivery device comprises a fluid reservoir for containing medicament. The fluid reservoir is sealed proximate one end with a sliding seal piston. A delivery path is configured to fluidly couple the fluid reservoir and a patient wearing the fluid delivery device. A basal engine mechanism is configured to directly or indirectly move the sliding seal piston in the fluid reservoir at a controlled basal rate. A bolus mechanism configured to move the basal engine relative to the fluid reservoir and directly or indirectly move the sliding seal piston in the fluid reservoir a discrete bolus amount at a time.

Claims (24)

1. A fluid delivery device comprising:

a housing including a fluid reservoir for containing medicament, the fluid reservoir being sealed proximate one end with a sliding seal piston;

a delivery path configured to fluidly couple the fluid reservoir and a patient wearing the fluid delivery device;

a basal actuator slidingly coupled to an inside surface of the fluid reservoir and configured to directly or indirectly move the sliding seal piston in the fluid reservoir at a controlled basal rate; and

a bolus actuator coupled to a proximal end of the basal actuator and configured to move the basal actuator relative to the fluid reservoir and move the sliding seal piston in the fluid reservoir a discrete bolus amount at a time,

wherein the basal actuator is contained within the bolus actuator, and

wherein the basal actuator includes a reservoir containing a hydraulic fluid under pressure from a stored energy source, the reservoir of the basal actuator including an aperture configured to release the hydraulic fluid at a rate determined by the force of the stored energy source, the viscosity of the hydraulic fluid and the geometry of the aperture.

2. The fluid delivery device of claim 1 , wherein the hydraulic fluid that is released by the reservoir of the basal actuator presses on the sliding seal piston.

3. The fluid delivery device of claim 1 , wherein the stored energy source includes one or more springs.

4. The fluid delivery device of claim 1 , wherein the stored energy source includes a compressed gas or a combustible material to create a compressed gas.

5. The fluid delivery device of claim 1 , wherein the basal actuator includes an electrochemical device that expands in at least one dimension while being charged or discharged.

6. The fluid delivery device of claim 5 , wherein the electrochemical device is connected to a circuit to control the charge or discharge rate.

7. The fluid delivery device of claim 5 , wherein the electrochemical device is connected to a circuit for user interface and device function,

wherein the circuit is powered by the discharge of the electrochemical device.

8. The fluid delivery device of claim 1 , wherein the sliding seal piston is in contact with the basal actuator and the medicament.

9. The fluid delivery device of claim 1 , wherein the basal actuator includes the sliding seal piston.

10. The fluid delivery device of claim 1 , wherein the basal actuator includes a sliding seal, the sliding seal being in contact with the hydraulic fluid that is in contact with the sliding seal piston.

11. The fluid delivery device of claim 1 , wherein the housing includes an adhesive patch configured to be adhered to a skin surface of a patient.

12. The fluid delivery device of claim 1 , wherein the delivery path includes a needle.

13. The fluid delivery device of claim 1 , wherein the bolus actuator includes a plunger.

14. The fluid delivery device of claim 13 , wherein the plunger includes a rack coupled to a pawl.

15. A method of using a fluid delivery device having a housing including a fluid reservoir configured to contain medicament, the fluid reservoir being sealed proximate one end with a sliding seal piston, a delivery path configured to fluidly couple the fluid reservoir and a patient wearing the fluid delivery device, a basal actuator within the housing and including an electrochemical device, and a bolus actuator coupled to a proximal end of the basal actuator, the method comprising the steps of:

expanding the electrochemical device by charging or discharging the electrochemical device to move the sliding seal piston in the fluid reservoir at a controlled basal rate; and

selectively sliding the basal actuator relative to the fluid reservoir and the housing to move the sliding seal piston in the fluid reservoir a discrete bolus amount at a time.

Assignments (7)
PATENT SECURITY AGREEMENT Recorded Aug 12, 2025
From: MANNKIND CORPORATION
To: WILMINGTON TRUST, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 072444/0525 →
RELEASE OF SECURITY INTEREST Recorded May 17, 2023
From: ZOOLANDER SA LLC
To: ZEALAND PHARMA A/S
Reel/Frame 063672/0342 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 2, 2022
From: ZEALAND PHARMA A/S
To: MANNKIND CORPORATION
Reel/Frame 060984/0295 →
RELEASE OF SECURITY INTEREST Recorded Aug 24, 2022
From: ZOOLANDER SA LLC
To: ZEALAND PHARMA A/S
Reel/Frame 060887/0685 →
PATENT SECURITY AGREEMENT Recorded Dec 27, 2021
From: ZEALAND PHARMA A/S
To: ZOOLANDER SA LLC
Reel/Frame 058593/0261 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 6, 2020
From: VALERITAS, INC.
To: ZEALAND PHARMA A/S
Reel/Frame 052859/0390 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 12, 2017
From: GONNELLI, ROBERT R.
To: VALERITAS, INC
Reel/Frame 044359/0176 →
Continuity (2)
Provisional Application 61934259 · Jan 31, 2014
Related Publication 20170000942A1 · Jan 5, 2017