Compounds and methods of use

1. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:

4-(5-bromo-2-(5-chloro-2-fluorophenyl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)pyrimidine-5-carboxamide;

1-((4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)pyridin-3-yl)methylamino)propan-2-ol;

4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(1-hydroxypropan-2-yl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(1-hydroxypropan-2-yl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(1-hydroxy-2-methylpropan-2-yl)nicotinamide;

(4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)pyridin-3-yl)(4-hydroxypiperidin-1-yl)methanone;

4-(2-(5-chloro-2-fluorophenyl)-5-vinylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-ethylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

(4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(2-hydroxypropyl)pyrimidine-5-carboxamide;

4-(2-(5-chloro-2-fluorophenyl)-5-methoxypyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

N-(2-acetamidoethyl)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)nicotinamide;

N-(2-amino-2-oxoethyl)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(dimethylamino)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(2-methoxypropan-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(2-(methylsulfonamido)ethyl)nicotinamide;

N-(2-aminoethyl)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)nicotinamide;

3-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)-1H-pyrazole-4-carboxamide;

3-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(2-hydroxypropyl)-1H-pyrazole-4-carboxamide;

4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide;

4-(2-amino-6-(5-chloro-2-fluorophenyl)-3-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(1-hydroxybutan-2-yl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxyethyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-cyclopropylnicotinamide;

N-(2-hydroxypropyl)-4-(5-isopropyl-2-phenylpyridin-4-ylamino)nicotinamide;

N-(3′-fluoro-5-isopropyl-2,2′-bipyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-amine;

N-(3′-fluoro-5-isopropyl-2,2′-bipyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;

4-(2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

N-(2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-amine;

4-(2-(5-chloro-2-fluorophenyl)-5-(pyrrolidin-1-yl)pyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide;

(4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)pyridin-3-yl)(pyrrolidin-1-yl)methanone;

N-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;

N-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;

4-(2-(2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(4-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(3-chlorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

N-(2-hydroxypropyl)-4-(5-(prop-1-en-2-yl)-2-(3-(trifluoromethyl)phenyl)pyridin-4-ylamino)nicotinamide;

N-[2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl]quinolin-4-amine;

N-[2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl]quinolin-5-amine;

4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(1-hydroxybutan-2-yl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(trifluoromethyl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-{[2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl]amino}-N-(oxetan-3-yl)pyridine-3-carboxamide;

4-{[2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl]amino}-N-(oxolan-3-yl)pyridine-3-carboxamide;

4-(2-(2-fluoro-5-(trifluoromethoxy)phenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-{[2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)pyridin-4-yl]amino}-N-(oxetan-3-yl)pyridine-3-carboxamide;

N-[2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)pyridin-4-yl]quinolin-4-amine;

N4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl)-N2-methylpyridine-2,4-diamine;

4-(2-(2,5-difluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(2,5-difluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(2-fluoro-5-(trifluoromethyl)phenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide; and

4-(2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide.

2. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:

4-(2-(5-chloro-2-fluorophenyl)-5-methylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-methylpyridin-4-ylamino)-N-(3-hydroxybutan-2-yl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-fluoropyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(5-tert-butoxy-2-(5-chloro-2-fluorophenyl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-methoxypyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-cyclobutylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(piperidin-1-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-morpholinopyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(4-methylpiperazin-1-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(piperazin-1-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(6-(5-chloro-2-fluorophenyl)-2,3-dimethylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(6-(5-chloro-2-fluorophenyl)-2-methyl-3-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(3′-fluoro-5-(prop-1-en-2-yl)-2,4′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(4′-fluoro-5-(prop-1-en-2-yl)-2,3′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(3′-fluoro-5-(prop-1-en-2-yl)-2,2′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2′-chloro-5-(prop-1-en-2-yl)-2,4′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(5′-chloro-5-(prop-1-en-2-yl)-2,3′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(4′-chloro-5-(prop-1-en-2-yl)-2,2′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(3′-fluoro-5-isopropyl-2,4′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(4′-fluoro-5-isopropyl-2,3′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(3′-fluoro-5-isopropyl-2,2′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2′-chloro-5-isopropyl-2,4′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(5′-chloro-5-isopropyl-2,3′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(4′-chloro-5-isopropyl-2,2′-bipyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

N-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-amine;

N-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl)-3H-imidazo[4,5-b]pyridin-7-amine;

N-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-amine;

(4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)pyridin-3-yl)(morpholino)methanone;

4-(2-chloro-6-(5-chloro-2-fluorophenyl)-3-isopropylpyridin-4-yl amino)-N-(2-hydroxypropyl)nicotinamide;

4-(6-(5-chloro-2-fluorophenyl)-3-isopropyl-2-methoxypyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(2-fluoro-5-methoxyphenyl)-5-isopropylpyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

(4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)pyridin-3-yl)(pyrrolidin-1-yl)methanone;

(4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)pyridin-3-yl)(morpholino)methanone;

4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(oxetan-3-yl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-ylamino)-N-(2-(methyl sulfonamido)ethyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(trifluoromethoxy)pyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(1-methylcyclopropyl)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

N-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl)quinolin-4-amine;

N-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;

N-(2-hydroxypropyl)-4-(5-isopropyl-2,4′-bipyridin-4-ylamino)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(methylamino)pyridin-4-ylamino)-N-(2-hydroxypropyl)nicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(methylamino)pyridin-4-ylamino)-N-cyclopropylnicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-cyclopropylpyridin-4-ylamino)-N-cyclopropylnicotinamide;

4-(2-(5-chloro-2-fluorophenyl)-5-(methylamino)pyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide;

N-(2-(5-chloro-2-fluorophenyl)-5-(prop-1-en-2-yl)pyridin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;

4-(5-amino-2-(5-chloro-2-fluorophenyl)pyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide; and

4-(2-(5-chloro-2-fluorophenyl)-5-methylpyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide.

3. A compound selected from the compounds in Tables 3 and 4, or a pharmaceutically acceptable salt thereof, with the proviso that the compound is not compound C-E 1, C-E 1a, or C-E 1b.

4. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle or excipient.

5. N-(2-aminoethyl)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)nicotinamide:

or a pharmaceutically acceptable salt thereof.

6. 4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide:

or a pharmaceutically acceptable salt thereof.

7. A pharmaceutical composition comprising N-(2-aminoethyl)-4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)nicotinamide:

or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable vehicle or excipient.

8. A pharmaceutical composition comprising a compound of claim 2 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle or excipient.

9. A pharmaceutical composition comprising a compound of claim 3 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle or excipient.

10. A pharmaceutical composition comprising 4-(2-(5-chloro-2-fluorophenyl)-5-isopropylpyridin-4-ylamino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide:

or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable vehicle or excipient.