EDIBLE ADHESIVES AND INGESTIBLE COMPOSITIONS INCLUDING THE SAME
Edible adhesives and ingestible compositions that include the same are provided. Aspects further include methods of making and using the compositions.
1 . An ingestible composition comprising:
an ingestible component;
an edible adhesive associated with the ingestible component, wherein the edible adhesive comprises:
a cellulose ether,
a tackifier and
a plasticizer; and
a highly-swellable polymeric film contacting the edible adhesive, wherein the highly-swellable polymeric film rapidly swells without disintegrating upon contact with an aqueous medium.
2 . The ingestible composition according to claim 1 , wherein the cellulose ether is an hydroxypropyl cellulose.
3 . The ingestible composition according to claim 1 , wherein the tackifier is a povidone.
4 . The ingestible composition according to claim 1 , wherein the plasticizer is glycerin.
5 . The ingestible composition according to claim 1 , wherein the edible adhesive consists of hydroxypropyl cellulose, povidone and glycerin.
6 . The ingestible composition according to claim 1 , wherein the highly-swellable polymeric film rapidly swells to ten times or greater in volume upon contact with an aqueous medium.
7 . The ingestible composition according to claim 1 , wherein the highly-swellable polymeric film comprises an ionic polymer.
8 . The ingestible composition according to claim 7 , wherein the ionic polymer is a polysaccharide.
9 . The ingestible composition according to claim 8 , wherein the polysaccharide is an alginate.
10 . The ingestible composition according to claim 9 , wherein the highly-swellable polymeric film further comprises a carboxyl functional group.
11 . The ingestible composition according to claim 10 , wherein the film comprises a polyacrylic acid.
12 - 14 . (canceled)
15 . The ingestible composition according to claim 1 , wherein the ingestible component is an ingestible event indicator that comprises:
a support;
circuitry associated with the support;
a first material electrically coupled to the circuitry and associated with the support; and
a second material electrically coupled to the circuitry, wherein the second material is associated with the support and is electrically isolated from the first material;
wherein the first and second materials are selected to provide a voltage potential difference when in contact with a conducting fluid.
16 . The ingestible composition according to claim 15 , wherein the highly-swellable polymeric film covers at least a portion of one of the first material or second material.
17 . The ingestible composition according to claim 16 , wherein the highly-swellable polymeric film covers at least a portion of both the first material and the second material.
18 - 19 . (canceled)
20 . A system comprising:
an ingestible composition comprising:
an ingestible component;
an edible adhesive associated with the ingestible component, wherein the edible adhesive comprises a cellulose ether, a tackifier and a plasticizer; and
a highly-swellable polymeric film contacting the edible adhesive, wherein the highly-swellable polymeric film rapidly swells without disintegrating upon contact with an aqueous medium; and
a receiver configured to receive a communication associated with the ingestible component.
21 . A method comprising combining:
an ingestible component,
an edible adhesive comprising:
a cellulose ether;
a tackifier; and
a plasticizer; and
a highly-swellable polymeric film, wherein the film rapidly swells without disintegrating upon contact with an aqueous medium.
22 . The method according to claim 21 , wherein the ingestible component is an ingestible event indicator.
23 . The method according to claim 21 , wherein the method comprises stably associating the ingestible component and the film with the adhesive.
24 . The method according to claim 23 , wherein the method comprises one or more protocols selected from the group consisting of laminating, pressing, stamping, extruding, molding, gluing and coating.
25 . The method according to claim 24 , wherein at least a portion of the method is automated.
26 - 30 . (canceled)