Antifungal compound process

1. A process to prepare amino-alcohol 1-6 or 1-7,

or a mixture thereof, the method comprising:

(i) forming the trimethylsilyl-cyanohydrin of aryl-pyridine 1-4,

 to provide trimethylsilyl-cyanohydrin 1-5 or 1-5a,

 or a mixture thereof; and

(ii) reducing trimethylsilyl-cyanohydrin 1-5 or 1-5a,

 or a mixture thereof, to provide amino-alcohol 1-6 or 1-7,

 or a mixture thereof;

wherein forming the trimethylsilyl-cyanohydrin is performed in the presence of a chiral catalyst.

2. The process of claim 1 , further comprising enriching the enantiomeric purity of amino-alcohol 1-6 or 1-7, the process comprising:

(i) crystallizing amino-alcohol 1-6 or 1-7 with a chiral acid in a suitable solvent or solvent mixture, wherein:

the suitable solvent or solvent mixture is selected from acetonitrile, isopropanol, ethanol, water, methanol, or combinations thereof;

(ii) isolating the enantio-enriched 1-6 or 1-7; and

(iii) free-basing the enantio-enriched chiral salt mixture to afford enantio-enriched amino-alcohol 1-6* or 1-7*,