Systems and methods for fast and reversible nerve block
One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.
1. A system, comprising:
a heat generator configured to provide a heat signal to an optrode, wherein the optrode is configured to apply the heat signal to a nerve to block conduction;
an electrical generator configured to provide an electrical signal to an electrode, wherein the electrode is configured to apply the electrical signal to the nerve to block conduction; and
a control device comprising a processor to regulate timing of the heat signal and the electrical signal,
wherein the heat signal and the electrical signal are applied simultaneously for a first period of 1 second or less so that the heat signal blocks an onset response in the nerve generated by the electrical signal, and after the first period of 1 second or less, the heat signal is stopped and the electrical signal is applied alone over a second period of at least one minute after the onset response.
2. The system of claim 1 , wherein the heat generator is configured to provide, through the optrode, at least one of an infrared light signal, a radio frequency signal, an ultrasound signal, and an electrical heating signal; and
wherein the electrical generator is configured to provide, through the electrode, at least one of a DC signal and a KHFAC signal.
3. The system of claim 1 , wherein the heat generator is configured to provide an infrared light signal through the optrode and the electrical generator is configured to provide a KHFAC signal through the electrode.