3-spirocyclic-6-hydroxamic acid tetralins as HDAC inhibitors

1. A compound of the Formula I:

X 1 , X 2 , X 3 , X 6 , and X 7 are each independently —CR 1 R 2 —, —NR 3 —, —O—, —C(O)—, —SO 2 —, —S(O)—, or —S—;

X 4 and X 5 are each independently —CR 1 R 2 —, —C(O)—, —SO 2 —, —S(O)—, or —S—;

Y 1 , Y 2 and Y 4 are each independently N or CR 1 ;

L is a bond, —(CR 1 R 2 ) n —, —C(O)NR 3 —, —S(O) 2 —, —S(O) 2 NR 3 —, —S(O)—, —S(O)NR 3 —, —C(O)(CR 1 R 2 ) n O—, or —C(O)(CR 1 R 2 ) n —;

R is independently —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, —C 5 -C 12 spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more —OH, halogen, oxo, —NO 2 , —CN, —R 1 , —R 2 , —SR 3 , —OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 1 , —C(O)R 1 , —CO 2 R 1 , —NR 3 S(O) 2 R 1 , —S(O)R 1 , —S(O)NR 3 R 4 , —NR 3 S(O)R 1 , heterocycle, aryl, or heteroaryl;

R 1 and R 2 are independently, at each occurrence, —H, —R 3 , —R 4 , —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O) 2 R 5 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, or —(CHR 5 ) n NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —OR 3 , —NHR 3 , NR 3 R 4 , —S(O) 2 N(R 3 ) 2 —, —S(O) 2 R 5 , —C(O)R 5 , —CO 2 R 5 , —NR 3 S(O) 2 R 5 , —S(O)R 5 , —S(O)NR 3 R 4 , —NR 3 S(O)R 5 , heterocycle, aryl, or heteroaryl;

or R 1 and R 2 can combine with the carbon atom to which they are both attached to form a cycloalkyl, heterocycle, spirocycle, spiroheterocycle, or spirocycloalkenyl;

or R 1 and R 2 , when on adjacent or non-adjacent atoms, can combine to form a heterocycle, cycloalkyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, or cycloalkenyl;

R 3 and R 4 are independently, at each occurrence, —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P, and O, —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, or —(CHR 5 ) n N(C 1 -C 6 alkyl) 2 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —O(C 1 -C 6 )alkyl, —NH(C 1 -C 6 )alkyl, —N(C 1 -C 6 alkly) 2 , —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 NHC 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, —S(O)R 5 , —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)R 5 , heterocycle, aryl, or heteroaryl;

R 5 is independently, at each occurrence, —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P and O, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 NH(C 1 -C 6 alkyl), —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 C 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, —S(O)(C 1 -C 6 alkyl), —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)(C 1 -C 6 alkyl) or —(CH 2 ) n N(C 1 -C 6 alkyl) 2 ;

n is an integer from 0 to 6; and

m is 0, 1, 2 or 3.

2. The compound of claim 1 , wherein X 4 is —C(O)—.

3. The compound of claim 1 , wherein the compound is of the Formula I-a:

4. The compound of claim 1 , wherein the compound is of the Formula I-b:

5. The compound of claim 1 , wherein the compound is of the Formula I-c:

6. The compound of claim 1 , wherein the compound is of the Formula I-d:

7. The compound of claim 1 , wherein the compound is of the Formula I-e:

8. The compound of claim 1 , wherein the compound is of the Formula I-f:

9. The compound of claim 1 , wherein the compound is of the Formula I-g:

10. The compound of claim 1 , wherein the compound is of the Formula I-h:

11. The compound of claim 1 , wherein the compound is of the Formula I-j:

12. The compound of claim 1 , wherein the compound is of the Formula I-k:

13. A compound of the Formula II:

or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer or thereof, wherein:

X 1 is independently —CR 1 R 2 —, —NR 3 —, —O—, —SO 2 —, —S(O)—, or —S—;

X 2 , X 3 , X 4 , and X 7 are each independently —CR 1 R 2 —, —NR 3 —, —O—, —C(O)—, —SO 2 —, —S(O)—, or —S—;

X 5 and X 6 are each independently —CR 1 R 2 —, —C(O)—, —SO 2 —, —S(O)—, or —S—;

Y 1 , Y 2 and Y 4 are each independently N or CR 1 ;

L is a bond, —(CR 1 R 2 ) n —, —C(O)NR 3 —, —S(O) 2 —, —S(O) 2 NR 3 —, —S(O)—, —S(O)NR 3 —, —C(O)(CR 1 R 2 ) n O—, or —C(O)(CR 1 R 2 ) n —;

R is independently —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, —C 5 -C 12 spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein each -alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more —OH, halogen, oxo, —NO 2 , —CN, —R 1 , —R 2 , —SR 3 , —OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 1 , —C(O)R 1 , —CO 2 R 1 , —NR 3 S(O) 2 R 1 , —S(O)R 1 , —S(O)NR 3 R 4 , —NR 3 S(O)R 1 , heterocycle, aryl, or heteroaryl;

R 1 and R 2 are independently, and at each occurrence, —H, —R 3 , —R 4 , —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O) 2 R 5 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, or —(CHR 5 ) n NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —OR 3 , —NHR 3 , NR 3 R 4 , —S(O) 2 N(R 3 ) 2 —, —S(O) 2 R 5 , —C(O)R 5 , —CO 2 R 5 , —NR 3 S(O) 2 R 5 , —S(O)R 5 , —S(O)NR 3 R 4 , —NR 3 S(O)R 5 , heterocycle, aryl, or heteroaryl;

or R 1 and R 2 can combine with the carbon atom to which they are both attached to form a cycloalkyl, heterocycle, spirocycle, spiroheterocycle, or spirocycloalkenyl;

or R 1 and R 2 , when on adjacent or non-adjacent atoms, can combine to form a heterocycle, cycloalkyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, or cycloalkenyl;

R 3 and R 4 are independently, at each occurrence, —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P and O, —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, or —(CHR 5 ) n N(C 1 -C 6 alkyl) 2 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —O(C 1 -C 6 )alkyl, —NH(C 1 -C 6 )alkyl, —N(C 1 -C 6 alkly) 2 , —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 NHC 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, —S(O)R 5 , —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)R 5 , heterocycle, aryl, or heteroaryl;

each R 5 is independently —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, O and P, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 NH(C 1 -C 6 alkyl), —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 C 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, —S(O)(C 1 -C 6 alkyl), —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)(C 1 -C 6 alkyl) or —(CH 2 ) n N(C 1 -C 6 alkyl) 2 ; and

n is an integer from 0 to 6.

14. The compound of claim 13 , wherein X 5 is C(O).

15. The compound of claim 13 , wherein the compound is of the Formula II-a:

16. The compound of claim 13 , wherein the compound is of the Formula II-b:

17. The compound of claim 13 , wherein the compound is of the Formula II-c:

18. The compound of claim 13 , wherein the compound is of the Formula II-d:

19. A compound of claim 1 selected from:

N-hydroxy-1′-(4-methoxybenzoyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-1);

N-hydroxy-1′-((4-methoxyphenyl)sulfonyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-2);

N-hydroxy-1′-(4-methoxybenzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-3);

1′-(cyclohexanecarbonyl)-N-hydroxy-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-4);

1′-cyclohexyl-N-hydroxy-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-5);

N7-hydroxy-N1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-1′,7-dicarboxamide (I-6);

1′-(cyclohexylsulfonyl)-N-hydroxy-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-7);

N-hydroxy-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-8);

N-hydroxy-1′-methyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-9);

1′-formyl-N-hydroxy-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-10);

N-hydroxy-1′-isopropyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-11);

1′-acetyl-N-hydroxy-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carb oxamide (I-12);

N-hydroxy-1′-(methyl sulfonyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-13);

N-hydroxy-1′-(3-methoxybenzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-14);

N-hydroxy-1′-(2-methoxybenzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-15);

(S)—N-hydroxy-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-16);

(R)—N-hydroxy-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-17);

(S)—N-hydroxy-1′-methyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-18);

(R)—N-hydroxy-1′-methyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-19);

N-hydroxy-1′-(4-methoxyphenethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-20);

1′-(3,4-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-21);

N-hydroxy-2′-oxo-1′-(pyridin-4-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-22);

1′-(cyclohexylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-23);

N-hydroxy-1′-isopropyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-24);

1′-(3-(dimethylamino)propyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-25);

N-hydroxy-2′-oxo-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-26);

1′-(4-chloro-3-(trifluoromethyl)benzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-27);

(S)—N-hydroxy-2′-oxo-1′-(pyridin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-28);

(R)—N-hydroxy-2′-oxo-1′-(pyridin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-29);

N-hydroxy-2′-oxo-1′-(pyridin-4-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-30);

(S)-1′-(1H-benzo[d]imidazol-2-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-31);

(R)-1′-(1H-benzo[d]imidazol-2-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-32);

(S)—N-hydroxy-1′-(1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-33);

(R)—N-hydroxy-1′-(1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-34);

(S)-1′-benzyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-35);

(R)-1′-benzyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-36);

(S)-1′-(4-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-37);

(R)-1′-(4-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-38);

(S)-1′-((5-chloropyridin-2-yl)methyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-39);

(R)-1′-((5-chloropyridin-2-yl)methyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-40);

(S)-1′-(4-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-41);

(R)-1′-(4-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-42);

(R)—N-hydroxy-2′-oxo-1′-(pyridin-2-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-43);

(S)—N-hydroxy-2′-oxo-1′-(pyridin-2-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-44);

(S)—N-hydroxy-1′-((1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-45);

(R)—N-hydroxy-1′-((1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-46);

(S)—N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-47);

(R)—N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-48);

(S)-1′-((2-chlorothiazol-5-yl)methyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-49);

(S)—N-hydroxy-1′-((2-hydroxythiazol-5-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-50);

(R)—N-hydroxy-1′-(4-(methylsulfonyl)benzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-51);

(S)—N-hydroxy-2′-oxo-1′-propyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-52);

(S)-1′-(cyclobutylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-53);

(S)—N-hydroxy-1′-isopentyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-54);

(S)-1′-(but-2-yn-1-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-55);

(S)—N-hydroxy-1′-(2-methoxyethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-56);

(S)—N-hydroxy-2′-oxo-1′-((tetrahydro-2H-pyran-4-yl)methyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-57);

(S)-1′-cinnamyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-58);

(S)—N-hydroxy-1′-(2-methylbenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-59);

(S)—N-hydroxy-2′-oxo-1′-(2-(trifluoromethyl)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-60);

(S)-1′-(2-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-61);

(S)—N-hydroxy-2′-oxo-1′-(2-(trifluoromethoxy)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-62);

(S)-1′-(benzo[c][1,2, 5]oxadiazol-5-ylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-63);

(S)—N-hydroxy-1′-(2-morpholino-2-oxoethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-64);

(S)—N-hydroxy-1′-(2-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-65);

(S)—N-hydroxy-1′-((1-isopropyl-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-66);

(S)-1′-(2,5-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-67);

(S)-1′-(2,6-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-68);

(S)—N-hydroxy-1′-(3-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-69);

(S)—N-hydroxy-2′-oxo-1′-(pyridin-3-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-70);

(S)—N-hydroxy-2′-oxo-1′-(pyridin-2-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-71);

(S)-1′-(3-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-72);

(S)—N-hydroxy-2′-oxo-1′-(4-(trifluoromethoxy)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-73);

(S)-1′-(3-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-74);

(S)—N-hydroxy-1′-(4-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-75);

(S)-1′-(2-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-76);

(S)—N-hydroxy-1′-(naphthalen-2-ylmethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-77);

(S)-1′-(2-(difluoromethoxy)benzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-78);

(R)—N-hydroxy-2′-oxo-1′-propyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-79);

(R)—N-hydroxy-1′-(3-hydroxypropyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-80);

(R)-1′-(cyclobutylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-81);

(R)—N-hydroxy-1′-isopentyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-82);

(R)-1′-(but-2-yn-1-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-83);

(R)—N-hydroxy-1′-(2-methoxyethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-84);

(R)—N-hydroxy-2′-oxo-1′-((tetrahydro-2H-pyran-4-yl)methyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-85);

(R)-1′-cinnamyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-86);

(R)—N-hydroxy-1′-(2-methylbenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-87);

(R)—N-hydroxy-2′-oxo-1′-(2-(trifluoromethyl)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-88);

(R)-1′-(2-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-89);

(R)—N-hydroxy-2′-oxo-1′-(2-(trifluoromethoxy)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-90);

(R)-1′-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-91);

(R)—N-hydroxy-1′-(2-morpholino-2-oxoethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-92);

(R)—N-hydroxy-1′-(2-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-93);

(R)-1′-(2,5-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-94);

(R)-1′-(2,6-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-95);

(R)—N-hydroxy-1′-(3-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-96);

(R)—N-hydroxy-2′-oxo-1′-(pyridin-3-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-97);

(R)—N-hydroxy-2′-oxo-1′-(pyridin-2-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-98);

(R)-1′-(3-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-99);

(R)—N-hydroxy-2′-oxo-1′-(4-(trifluoromethoxy)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-100);

(R)-1′-(3-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-101);

(R)—N-hydroxy-1′-(4-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-102);

(R)-1′-(2-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-103);

(R)—N-hydroxy-1′-(naphthalen-2-ylmethyl)-2′-oxo-3,4-dihydro-H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-104);

(R)-1′-(2-(difluoromethoxy)benzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-105);

(R)—N-hydroxy-2′-oxo-1′-(4-phenoxyphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-106);

(R)—N-hydroxy-2′-oxo-1′-(quinolin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-107);

(R)-1′-(2,3-dihydrobenzofuran-7-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-108);

(R)-1′-(1,3-dimethyl-1H-pyrazol-4-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-109);

(R)—N-hydroxy-1′-(imidazo[1,2-a]pyridin-6-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-110);

(R)—N-hydroxy-1′-(imidazo[1,2-a]pyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-111);

(S)-1′-(3,4-dichlorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-112);

(S)-1′-(2,4-dimethylphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-113);

(S)—N-hydroxy-1′-(2-methoxyphenyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-114);

(S)-1′-(benzo[d][1,3]dioxol-5-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-115);

(S)—N-hydroxy-2′-oxo-1′-(4-phenoxyphenyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-116);

(R)—N-hydroxy-1′-(3-(2-morpholinoethoxy)phenyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-117);

(S)—N-hydroxy-2′-oxo-1′-(quinolin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-118);

(S)-1′-(4-(2-(dimethylamino)ethyl)phenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-119);

(R)—N-hydroxy-1′-methyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-120);

(S)—N-hydroxy-1′-methyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-121);

(S)—N-hydroxy-1′-(4-methylbenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-122);

(R)—N-hydroxy-1′-(4-methylbenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-123);

(S)-1′-(3-fluoro-4-(trifluoromethyl)benzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-124);

(R)-1′-(3-fluoro-4-(trifluoromethyl)benzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-125);

(S)—N-hydroxy-2′-oxo-1′-(4-(trifluoromethyl)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-126);

(R)—N-hydroxy-2′-oxo-1′-(4-(trifluoromethyl)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-127);

(R)-1′-(4-fluorobenzyl)-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-128);

(S)-1′-(4-fluorobenzyl)-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-129);

(R)—N-hydroxy-1′-methyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-130);

(S)—N-hydroxy-1′-methyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-131);

(S)—N-hydroxy-5′-oxo-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-132);

(R)-1′-(cyclobutylmethyl)-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-133);

(S)-1′-(cyclobutylmethyl)-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-134);

(R)—N-hydroxy-′-(3-methoxypropyl)-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-135);

(S)—N-hydroxy-1′-(3-methoxypropyl)-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-136);

(R)—N-hydroxy-1′-isobutyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-137);

(S)—N-hydroxy-1′-isobutyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-138);

(R)—N-hydroxy-1′-isopropyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-139);

(S)—N-hydroxy-1′-isopropyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-140);

(S)-1′-cyclopropyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-141);

(R)-1′-ethyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-142);

(S)-1′-ethyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-143);

(S)—N-hydroxy-5′-oxo-1′-(2,2,2-trifluoroethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-144);

(R)—N-hydroxy-5′-oxo-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-145);

(R)—N-hydroxy-1′-(oxetan-3-ylmethyl)-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-146);

(S)—N-hydroxy-1′-(oxetan-3-ylmethyl)-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-147);

(R)-1′-cyclopropyl-N-hydroxy-5′-oxo-3,4-dihydro-H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-148);

(R)—N-hydroxy-5′-oxo-1′-(2,2,2-trifluoroethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-149);

(R)-1′-cyclobutyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-150);

(S)-1′-cyclobutyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-151);

(R)-1′-cyclopentyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-152); or

(S)-1′-cyclopentyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-7-carboxamide (I-153).

20. A compound of claim 13 selected from:

N-hydroxy-1′-(4-methoxybenzoyl)spiro[chromane-2,4′-piperidine]-7-carboxamide (II-1);

N-hydroxy-1′-((4-methoxyphenyl)sulfonyl)spiro[chromane-2,4′-piperidine]-7-carboxamide (II-2);

1′-(cyclohexylsulfonyl)-N-hydroxyspiro[chromane-2,4′-piperidine]-7-carboxamide (II-3);

N7-hydroxy-N1′-phenylspiro[chromane-2,4′-piperidine]-1′,7-dicarboxamide (II-4);

1′-(cyclohexanecarbonyl)-N-hydroxyspiro[chromane-2,4′-piperidine]-7-carboxamide (II-5);

1′-cyclohexyl-N-hydroxyspiro[chromane-2,4′-piperidine]-7-carboxamide (II-6); or

N-hydroxy-1′-(4-methoxybenzyl)spiro[chromane-2,4′-piperidine]-7-carboxamide (II-7).

21. A compound of claim 1 selected from:

N-hydroxy-1′-methyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-7-carboxamide (I-154);

N-hydroxy-1-methyl-3′,4′-dihydro-1′H-spiro[azepane-3,2′-naphthalene]-7′-carb oxamide (I-155);

N-hydroxy-1-methyl-3′,4′-dihydro-1′H-spiro[azocane-3,2′-naphthalene]-7′-carboxamide (I-156);

N-hydroxy-1′-methyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-7-carboxamide (I-157);

N-hydroxy-1-methyl-2-oxo-3′,4′-dihydro-1′H-spiro[azepane-3,2′-naphthalene]-7′-carboxamide (I-158);

N-hydroxy-1-methyl-2-oxo-3′,4′-dihydro-1′H-spiro[azocane-3,2′-naphthalene]-7′-carboxamide (I-159);

N-hydroxy-1′-methyl-6′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-7-carboxamide (I-160);

N-hydroxy-1-methyl-7-oxo-3′,4′-dihydro-1′H-spiro[azepane-3,2′-naphthalene]-7′-carboxamide (I-161); or

N-hydroxy-1-methyl-8-oxo-3′,4′-dihydro-1′H-spiro[azocane-3,2′-naphthalene]-7′-carboxamide (I-162).

22. A pharmaceutical composition comprising a compound of claim 1 or claim 13 and a pharmaceutically acceptable carrier.

23. A method of treating a cancer, selected from lung cancer, ovarian cancer, hepatocellular carcinoma, lymphoma, leukemia, non small cell lung carcinoma, breast cancer, cutaneous T-cell lymphoma, peripheral T-cell lymphoma, Hodgkin lymphoma, melanoma, squamous cell caricinoma, myeloproliferative neoplasms, metastic solid tumor, myelodysplastic syndrome, myelofibrosis, urothelial cancer, or multiple myeloma, comprising administering to a subject in need thereof an effective amount of a compound of claim 1 or claim 13 .

24. A method of treating a neurodegenerative disease selected from Alzheimer's disease, Parkinson's Disease, Huntington's Disease, ALS, depression, Rett Syndrome, or Chartot-Marie-Tooth Disease, comprising administering to a subject in need thereof an effective amount of a compound of claim 1 or claim 13 .

25. A method of treating an immunological disease selected from systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease; or allograft transplantation, comprising administering to a subject in need thereof an effective amount of a compound of claim 1 or claim 13 .

26. A method of inhibiting a histone deacetylase, comprising administering to a subject in need thereof an effective amount of a compound of claim 1 or claim 13 .

27. The method of claim 26 , wherein the compound inhibits a zinc-dependent histone deacetylase.

28. The method of claim 26 , wherein the compound inhibits the HDAC6 isozyme zinc-dependent histone deacetylase.

29. The method of claim 26 , wherein the compound inhibits the HDAC11 isozyme zinc-dependent histone deacetylase.

30. The method of claim 23 , wherein the lymphoma is selected from B-cell lymphoma or non-Hodgkin's lymphoma.

31. The method of claim 23 , wherein the leukemia is selected from acute myeloid leukemia and chronic lymphocytotic leukemia.