3-spiro-7-hydroxamic acid tetralins as HDAC inhibitors

1. A compound of the Formula I:

or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer or thereof, wherein:

X 1 , X 2 , X 3 , X 6 , and X 7 are each independently —CR 1 R 2 —, —NR 3 —, —O—, —C(O)—, —SO 2 —, —S(O)—, or —S—;

X 4 and X 5 are each independently —CR 1 R 2 —, —C(O)—, —SO 2 —, —S(O)—, or —S—;

Y 1 , Y 3 and Y 4 are each independently N or CR 1 ;

L is a bond, —(CR 1 R 2 ) n —, —C(O)NR 3 —, —S(O) 2 —, —S(O) 2 NR 3 —, —S(O)—, —S(O)NR 3 —, —C(O)(CR 1 R 2 ) n O—, or —C(O)(CR 1 R 2 ) n —;

R is independently —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, —C 5 -C 12 spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more —OH, halogen, oxo, —NO 2 , —CN, —R 1 , —R 2 , —SR 3 , —OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 1 , —C(O)R 1 , —CO 2 R 1 , —NR 3 S(O) 2 R 1 , —S(O)R 1 , —S(O)NR 3 R 4 , —NR 3 S(O)R 1 , heterocycle, aryl, or heteroaryl;

R 1 and R 2 are independently, at each occurrence, —H, —R 3 , —R 4 , —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O) 2 R 5 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, or (CHR 5 ) n NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —OR 3 , —NHR 3 , NR 3 R 4 , —S(O) 2 N(R 3 ) 2 —, —S(O) 2 R 5 , —C(O)R 5 , —CO 2 R 5 , —NR 3 S(O) 2 R 5 , —S(O)R 5 , —S(O)NR 3 R 4 , —NR 3 S(O)R 5 , heterocycle, aryl, or heteroaryl;

or R 1 and R 2 can combine with the carbon atom to which they are both attached to form a cycloalkyl, heterocycle, spirocycle, spiroheterocycle, or spirocycloalkenyl;

or R 1 and R 2 , when on adjacent or non-adjacent atoms, can combine to form a heterocycle, cycloalkyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, or cycloalkenyl;

R 3 and R 4 are independently, at each occurrence, —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P, and O, —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, or —(CHR 5 ) n N(C 1 -C 6 alkyl) 2 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —O(C 1 -C 6 )alkyl, —NH(C 1 -C 6 )alkyl, —N(C 1 -C 6 alkly) 2 , —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 NHC 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, —S(O)R 5 , —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)R 5 , heterocycle, aryl, or heteroaryl;

R 5 is independently, at each occurrence, —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P and O, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 NH(C 1 -C 6 alkyl), —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 C 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, —S(O)(C 1 -C 6 alkyl), —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)(C 1 -C 6 alkyl) or —(CH 2 ) n N(C 1 -C 6 alkyl) 2 ;

n is an integer from 0 to 6; and

m is 0, 1, 2 or 3.

2. The compound of claim 1 , wherein X 4 is —C(O)—.

3. The compound of claim 1 , wherein m is 0 or 1.

4. The compound of claim 1 , wherein the compound is of the Formula I-a:

5. The compound of claim 1 , wherein the compound is of the Formula I-b:

6. The compound of claim 1 , wherein the compound is of the Formula I-c:

7. The compound of claim 1 , wherein the compound is of the Formula I-d:

8. The compound of claim 1 , wherein the compound is of the Formula I-e:

9. The compound of claim 1 , wherein the compound is of the Formula I-f:

10. The compound of claim 1 , wherein the compound is of the Formula I-g:

11. The compound of claim 1 , wherein the compound is of the Formula I-h:

12. The compound of claim 1 , wherein the compound is of the Formula I-j:

13. The compound of claim 1 , wherein the compound is of the Formula I-k:

14. The compound of claim 1 , wherein the compound is of the Formula I-m:

15. A compound of the Formula II:

or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, tautomer, or isomer or thereof, wherein:

X 1 is independently —CR 1 R 2 —, —NR 3 —, —O—, —SO 2 —, —S(O)—, or —S—;

X 2 , X 3 , X 4 , and X 7 are each independently —CR 1 R 2 —, —NR 3 —, —O—, —C(O)—, —SO 2 —, —S(O)—, or —S—;

X 5 and X 6 are each independently —CR 1 R 2 —, —C(O)—, —SO 2 —, —S(O)—, or —S—;

Y 1 , Y 3 and Y 4 are each independently N or CR 1 ;

L is a bond, —(CR 1 R 2 ) n —, —C(O)NR 3 —, —S(O) 2 —, —S(O) 2 NR 3 —, —S(O)—, —S(O)NR 3 —, —C(O)(CR 1 R 2 ) n O—, or —C(O)(CR 1 R 2 ) n —;

R is independently —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, —C 5 -C 12 spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein each -alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more —OH, halogen, oxo, —NO 2 , —CN, —R 1 , —R 2 , —SR 3 , —OR 3 , —NHR 3 , —NR 3 R 4 , —S(O) 2 NR 3 R 4 , —S(O) 2 R 1 , —C(O)R 1 , —CO 2 R 1 , —NR 3 S(O) 2 R 1 , —S(O)R 1 , —S(O)NR 3 R 4 , —NR 3 S(O)R 1 , heterocycle, aryl, or heteroaryl;

R 1 and R 2 are independently, and at each occurrence, —H, —R 3 , —R 4 , —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O) 2 R 5 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, or (CHR 5 ) n NR 3 R 4 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —OR 3 , —NHR 3 , NR 3 R 4 , —S(O) 2 N(R 3 ) 2 —, —S(O) 2 R 5 , —C(O)R 5 , —CO 2 R 5 , —NR 3 S(O) 2 R 5 , —S(O)R 5 , —S(O)NR 3 R 4 , —NR 3 S(O)R 5 , heterocycle, aryl, or heteroaryl;

or R 1 and R 2 can combine with the carbon atom to which they are both attached to form a cycloalkyl, heterocycle, spirocycle, spiroheterocycle, or spirocycloalkenyl;

or R 1 and R 2 , when on adjacent or non-adjacent atoms, can combine to form a heterocycle, cycloalkyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, or cycloalkenyl;

R 3 and R 4 are independently, at each occurrence, —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P and O, —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 (C 1 -C 6 alkyl), —(C 1 -C 6 alkyl)S(O) 2 R 5 , —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, or —(CHR 5 ) n N(C 1 -C 6 alkyl) 2 , wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from —OH, halogen, —NO 2 , oxo, —CN, —R 5 , —O(C 1 -C 6 )alkyl, —NH(C 1 -C 6 )alkyl, —N(C 1 -C 6 alkly) 2 , —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 NHC 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)S(O) 2 C 1 -C 6 alkyl, —S(O)R 5 , —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)R 5 , heterocycle, aryl, or heteroaryl;

each R 5 is independently —H, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 4 -C 8 cycloalkenyl, —C 2 -C 6 alkynyl, —C 3 -C 8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, O and P, —OH, halogen, —NO 2 , —CN, —NHC 1 -C 6 alkyl, —N(C 1 -C 6 alkyl) 2 , —S(O) 2 NH(C 1 -C 6 alkyl), —S(O) 2 N(C 1 -C 6 alkyl) 2 , —S(O) 2 C 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —CO 2 C 1 -C 6 alkyl, —N(C 1 -C 6 alkyl)SO 2 C 1 -C 6 alkyl, —S(O)(C 1 -C 6 alkyl), —S(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)S(O)(C 1 -C 6 alkyl) or —(CH 2 ) n N(C 1 -C 6 alkyl) 2 ; and

n is an integer from 0 to 6.

16. The compound of claim 15 , wherein X 5 is C(O).

17. The compound of claim 15 wherein the compound is of the Formula II-a:

18. The compound of claim 15 , wherein the compound is of the Formula II-b:

19. The compound of claim 15 , wherein the compound is of the Formula II-c:

20. The compound of claim 15 , wherein the compound is of the Formula II-d:

21. The compound of claim 15 , wherein the compound is of the Formula II-e:

22. A compound of claim 1 selected from:

1′-((1H-benzo[d]imidazol-2-yl)methyl)-N-hydroxy-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-1);

N-hydroxy-1′-(4-methoxyphenethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-2);

N-hydroxy-1′-(4-methoxybenzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-3);

N-hydroxy-1′-(4-methoxyphenethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-4);

1′-(1H-benzo[d]imidazol-2-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-5);

1′-(3,4-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-6);

1′-(cyclohexylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-7);

N-hydroxy-1′-(4-methylbenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-8);

1′-(3-(dimethylamino)propyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-9);

(R)-N-hydroxy-2′-oxo-1′-(pyridin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-10);

(S)-N-hydroxy-2′-oxo-1′-(pyridin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-11);

(R)-N-hydroxy-1′-(1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-12);

(S)-N-hydroxy-1′-(1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-13);

(R)-N-hydroxy-2′-oxo-1′-(pyridin-4-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-14);

(S)-N-hydroxy-2′-oxo-1′-(pyridin-4-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-15);

(R)-N-hydroxy-2′-oxo-1′-(pyridin-4-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-16);

(S)-N-hydroxy-2′-oxo-1′-(pyridin-4-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-17);

(R)-N-hydroxy-2′-oxo-1′-(pyridin-3-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-18);

(S)-N-hydroxy-2′-oxo-1′-(pyridin-3-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-19);

(R)-N-hydroxy-2′-oxo-1′-(pyridin-2-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-20);

(S)-N-hydroxy-2′-oxo-1′-(pyridin-2-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-21);

(R)-N-hydroxy-1′-((1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-22);

(S)-N-hydroxy-1′-((1-(2-methoxyethyl)-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-23);

(R)-N-hydroxy-1′-isopropyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-24);

(S)-N-hydroxy-1′-isopropyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-25);

(R)-N-hydroxy-2′-oxo-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-26);

(R)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-27);

(S)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-28);

(S)-N-hydroxy-2′-oxo-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-29);

(R)-1′-((2-chlorothiazol-5-yl)methyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-30);

(R)-N-hydroxy-1′-((2-hydroxythiazol-5-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-31);

(R)-N-hydroxy-2′-oxo-1′-propyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-32);

(R)-1′-(cyclobutylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-33);

(R)-N-hydroxy-1′-isopentyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-34);

(R)-1′-(but-2-yn-1-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-35);

(R)-N-hydroxy-1′-(2-methoxyethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-36);

(R)-1′-cinnamyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-37);

(R)-N-hydroxy-1′-(2-methylbenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-38);

(R)-N-hydroxy-2′-oxo-1′-(2-(trifluoromethyl)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-39);

(R)-1′-(2-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-40);

(R)-N-hydroxy-2′-oxo-1′-(2-(trifluoromethoxy)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-41);

(R)-1′-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-42);

(R)-N-hydroxy-1′-(2-morpholino-2-oxoethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-43);

(R)-N-hydroxy-1′-(2-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-44);

(R)-N-hydroxy-1′-((1-isopropyl-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-45);

(R)-N-hydroxy-1′-((1-methyl-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-46);

(R)-N-hydroxy-1′-(2-methylallyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-47);

(R)-1′-(2,5-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-48);

(R)-1′-(2,6-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-49);

(R)-1′-benzyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-50);

(R)-N-hydroxy-1′-(3-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-51);

(R)-N-hydroxy-2′-oxo-1′-(pyridin-2-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-52);

(R)-1′-(3-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-53);

(R)-1′-(3-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-54);

(R)-1′-(4-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-55);

(R)-N-hydroxy-1′-(4-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-56);

(R)-1′-(2-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-57);

(R)-N-hydroxy-1′-(naphthalen-2-ylmethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-58);

(R)-1′-(2-(difluoromethoxy)benzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-59);

(S)-N-hydroxy-2′-oxo-1′-propyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-60);

(S)-1′-(cyclobutylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-61);

(S)-N-hydroxy-1′-isopentyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-62);

(S)-1′-(but-2-yn-1-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-63);

(S)-N-hydroxy-1′-(2-methoxyethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-64);

(S)-1′-cinnamyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-65);

(S)-N-hydroxy-1′-(2-methylbenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-66);

(S)-N-hydroxy-2′-oxo-1′-(2-(trifluoromethyl)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-67);

(S)-1′-(2-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-68);

(S)-N-hydroxy-2′-oxo-1′-(2-(trifluoromethoxy)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-69);

(S)-1′-(benzo[c][1,2,5]oxadiazol-5-ylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-70);

(S)-N-hydroxy-1′-(2-morpholino-2-oxoethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-71);

(S)-N-hydroxy-1′-(2-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-72);

(S)-N-hydroxy-1′-((1-isopropyl-1H-benzo[d]imidazol-2-yl)methyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-73);

(S)-1′-(2,5-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-74);

(S)-1′-(2,6-dichlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-75);

(S)-1′-benzyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-76);

(S)-N-hydroxy-1′-(3-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-77);

(S)-N-hydroxy-2′-oxo-1′-(pyridin-2-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-78);

(S)-1′-(3-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-79);

(S)-N-hydroxy-2′-oxo-1′-(4-(trifluoromethoxy)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-80);

(S)-1′-(3-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-81);

(S)-1′-(4-chlorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-82);

(S)-N-hydroxy-1′-(4-methoxybenzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-83);

(S)-1′-(2-fluorobenzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-84);

(S)-1′-(4-(tert-butyl)benzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-85);

(S)-N-hydroxy-1′-(naphthalen-2-ylmethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-86);

(S)-1′-(2-(difluoromethoxy)benzyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-87);

(R)-N-hydroxy-1′-(4-(methylsulfonyl)benzyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-88);

(R)-N-hydroxy-1′-(naphthalen-1-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-89);

(R)-1′-(3-fluoro-4-methoxyphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-90);

(R)-1′-(benzo[d][1,3]dioxol-5-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-91);

(R)-N-hydroxy-1′-(3-(methylthio)phenyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-92);

(R)-1′-(4-(dimethylamino)phenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-93);

(R)-N-hydroxy-1′-(6-isopropylpyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-94);

(R)-N-hydroxy-2′-oxo-1′-(quinolin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-95);

(R)-1′-(2,3-dihydrobenzofuran-7-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-96);

(R)-1′-(6-(tert-butylamino)pyrimidin-4-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-97);

(R)-1′-(1,3-dimethyl-1H-pyrazol-4-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-98);

(R)-N-hydroxy-1′-(imidazo[1,2-a]pyridin-6-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-99);

(S)-1′-(2,4-dimethylphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-100);

(S)-N-hydroxy-1′-(6-isopropylpyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-101);

(S)-N-hydroxy-2′-oxo-1′-(quinolin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-102);

(S)-N-hydroxy-1′-(imidazo[1,2-a]pyridin-6-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-103);

(R)-N-hydroxy-1′-methyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-104);

(S)-N-hydroxy-1′-methyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-105);

(R)-N-hydroxy-2′-oxo-1′-(4-((trifluoromethyl)sulfonyl)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-106);

(S)-N-hydroxy-2′-oxo-1′-(4-((trifluoromethyl)sulfonyl)benzyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-107);

(R)-N-hydroxy-1′-(3-methoxyphenyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-108);

(R)-1′-cyclopropyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-109);

(R)-1′-(5-fluoropyridin-3-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-110);

(R)-N-hydroxy-1′-(2-methoxyphenyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-111);

(R)-1′-(3-cyanophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-112);

(R)-1′-(3-fluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-113);

(R)-N-hydroxy-1′-(6-methoxypyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-114);

(S)-N-hydroxy-1′-(2-methoxyphenyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-115);

(S)-1′-(3-cyanophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-116);

(S)-1′-(3-fluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-117);

(S)-N-hydroxy-1′-(6-methoxypyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-118);

(R)-1′-(3,4-difluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-119);

(R)-1′-(4-fluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-120);

(R)-1′-(2-fluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-121);

(S)-N-hydroxy-1′-(oxetan-3-ylmethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-122);

(R)-1′-(2,3-difluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-123);

(R)-N-hydroxy-1′-(4-methoxyphenyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-124);

(R)-1′-(2-fluoro-3-methoxyphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-125);

(S)-1′-(2-fluoro-3-methoxyphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-126);

(S)-1′-(2-fluoro-4-methoxyphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-127);

(R)-1′-(4-fluoro-3-methoxyphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-128);

(S)-1′-(4-fluoro-3-methoxyphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-129);

(S)-1′-(5-chloropyridin-2-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-130);

(R)-N-hydroxy-1′-(2-methylpyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-131);

(S)-N-hydroxy-1′-(2-methylpyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-132);

(R)-N-hydroxy-1′-(6-methylpyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-133);

(S)-N-hydroxy-1′-(6-methylpyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-134);

(R)-N-hydroxy-1′-(5-methylpyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-135);

(R)-N-hydroxy-1′-(4-methylpyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-136);

(S)-N-hydroxy-1′-(4-methylpyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-137);

(R)-1′-(5-chloropyridin-3-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-138);

(S)-1′-(5-chloropyridin-3-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-139);

(R)-1′-(3-chloropyridin-4-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-140);

(S)-1′-(3-chloropyridin-4-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-141);

(S)-N-hydroxy-1′-(4-methoxypyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-142);

(R)-N-hydroxy-1′-(5-methoxypyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-143);

(S)-N-hydroxy-1′-(5-methoxypyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-144);

(R)-N-hydroxy-1′-(2-methoxypyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-145);

(S)-N-hydroxy-1′-(2-methoxypyridin-3-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-146);

(S)-1′-(2-fluoro-5-methoxyphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-147);

(S)-1′-(3-fluoro-5-methoxyphenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-148);

(R)-N-hydroxy-1′-(2-methoxypyridin-4-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-149);

(S)-N-hydroxy-1′-(2-methoxypyridin-4-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-150);

(R)-1′-(6-(dimethylamino)pyridin-3-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-151);

(S)-1′-(6-(dimethylamino)pyridin-3-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-152);

(S)-1′-(5-fluoropyridin-3-yl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-153);

(S)-1′-(4-fluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-154);

(S)-1′-(3,4-difluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-155);

(S)-1′-(2,3-difluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-156);

(S)-1′-(2-fluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-157);

(S)-N-hydroxy-1′-(3-methoxyphenyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-158);

(R)-N-hydroxy-1′-isobutyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-159);

(S)-N-hydroxy-1′-isobutyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-160);

(R)-1′-ethyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-161);

(S)-1′-ethyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-162);

(R)-1′-cyclopentyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-163);

(S)-1′-cyclopentyl-N-hydroxy-2′-oxo-3,4-dihydro-H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-164);

(R)-N-hydroxy-2′-oxo-1′-(2,2,2-trifluoroethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-165);

(S)-N-hydroxy-2′-oxo-1′-(2,2,2-trifluoroethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-166);

(R)-1′-(2, 5-difluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-167);

(R)-N-hydroxy-1′-(1-methyl-1H-pyrazol-4-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-168);

(S)-1′-(2,5-difluorophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-169);

(S)-N-hydroxy-1′-(1-methyl-1H-pyrazol-4-yl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-170);

(R)-1′-cyclobutyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-171);

(S)-1′-cyclobutyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-172);

(S)-1′-(4-cyanophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-173);

(S)-1′-(2-cyanophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-174);

(R)-1′-(2-cyanophenyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-175);

1′-benzyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-176);

N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-177);

N-hydroxy-1′-methyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-178);

(R)-N-hydroxy-1′-methyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-179);

(S)-N-hydroxy-1′-methyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-180);

(R)-N-hydroxy-2′-oxo-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-181);

(S)-N-hydroxy-2′-oxo-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-182);

(S)-1′-cyclopropyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-183);

(S)-1′-ethyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-184);

(R)-1′-(cyclobutylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-185);

(S)-1′-(cyclobutylmethyl)-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-186);

(R)-N-hydroxy-1′-(3-methoxypropyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-187);

(S)-N-hydroxy-1′-(3-methoxypropyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-188);

(R)-N-hydroxy-1′-isobutyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-189);

(S)-N-hydroxy-1′-isobutyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-190);

(R)-N-hydroxy-1′-isopropyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-191);

(S)-N-hydroxy-1′-isopropyl-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-192);

(R)-1′-cyclopropyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-193);

(R)-1′-ethyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-194);

(S)-N-hydroxy-1′-(oxetan-3-ylmethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-195);

(R)-N-hydroxy-1′-(oxetan-3-ylmethyl)-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-196);

(R)-1′-cyclobutyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-197);

(S)-1′-cyclobutyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-198);

(R)-1′-cyclopentyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-199);

(S)-1′-cyclopentyl-N-hydroxy-2′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-200);

(R)-N-hydroxy-1′-methyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-201);

(S)-N-hydroxy-1′-methyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-202);

(R)-N-hydroxy-5′-oxo-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-203);

(S)-N-hydroxy-5′-oxo-1′-phenyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-204);

(R)-1′-(cyclobutylmethyl)-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-205);

(R)-1′-ethyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-206);

(R)-N-hydroxy-1′-isobutyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-207);

(R)-N-hydroxy-1′-isopropyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-208);

(R)-1′-cyclopropyl-N-hydroxy-5′-oxo-3,4-dihydro-H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-209);

(S)-1′-(cyclobutylmethyl)-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-210);

(S)-1′-ethyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-211);

(S)-N-hydroxy-1′-isobutyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-212);

(S)-N-hydroxy-1′-isopropyl-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-213);

(S)-1′-cyclopropyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-214);

(R)-N-hydroxy-1′-(oxetan-3-ylmethyl)-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-215);

(R)-1′-benzyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-216);

(S)-N-hydroxy-1′-(oxetan-3-ylmethyl)-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-217);

(S)-1′-benzyl-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-218);

(R)-N-hydroxy-1′-(3-methoxypropyl)-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-219);

(R)-N-hydroxy-5′-oxo-1′-(2,2,2-trifluoroethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-220);

(R)-N-hydroxy-5′-oxo-1′-(pyridin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-221);

(S)-N-hydroxy-1′-(3-methoxypropyl)-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-222);

(S)-N-hydroxy-5′-oxo-1′-(2,2,2-trifluoroethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-223);

(S)-N-hydroxy-5′-oxo-1′-(pyridin-3-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-224);

(R)-N-hydroxy-1′-(2-methylbenzyl)-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-225);

(R)-N-hydroxy-5′-oxo-1′-(pyridin-3-ylmethyl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-226);

(R)-1′-(4-fluorophenyl)-N-hydroxy-5′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-227);

(R)-N-hydroxy-5′-oxo-1′-(pyridin-4-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-228);

(R)-N-hydroxy-5′-oxo-1′-(pyridin-2-yl)-3,4-dihydro-1H-spiro[naphthalene-2,3′-pyrrolidine]-6-carboxamide (I-229);

N-hydroxy-2′-oxo-1′-(pyridin-4-ylmethyl)spiro[chromane-2,3′-pyrrolidine]-6-carboxamide (I-230);

N-hydroxy-2′-oxo-1′-phenylspiro[chromane-2,3′-pyrrolidine]-6-carboxamide (I-231);

1′-benzyl-N-hydroxy-2′-oxospiro[chromane-2,3′-pyrrolidine]-6-carboxamide (I-232);

N-hydroxy-2′-oxo-1′-(pyridin-3-yl)spiro[chromane-2,3′-pyrrolidine]-6-carboxamide (I-233);

N-hydroxy-2′-oxo-1′-((tetrahydro-2H-pyran-4-yl)methyl)spiro[chromane-2,3′-pyrrolidine]-6-carboxamide (I-234);

N-hydroxy-1′-isopropyl-2′-oxospiro[chromane-2,3′-pyrrolidine]-6-carboxamide (I-235);

N-hydroxy-2′-oxospiro[chromane-2,3′-pyrrolidine]-6-carboxamide (I-236);

N-hydroxy-1′-methyl-2′-oxospiro[chromane-2,3′-pyrrolidine]-6-carboxamide (I-237);

N-hydroxy-2-oxo-1-phenylspiro[pyrrolidine-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-238);

1-benzyl-N-hydroxy-2-oxospiro[pyrrolidine-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-239);

N-hydroxy-2-oxo-1-(pyridin-3-yl)spiro[pyrrolidine-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-240);

N-hydroxy-2-oxo-1-((tetrahydro-2H-pyran-4-yl)methyl)spiro[pyrrolidine-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-241);

N-hydroxy-2-oxo-1-(pyridin-4-ylmethyl)spiro[pyrrolidine-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-242);

N-hydroxy-2-oxospiro[pyrrolidine-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-243); or

N-hydroxy-1-methyl-2-oxospiro[pyrrolidine-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-244).

23. A compound of claim 15 selected from:

N-hydroxy-1′-(4-methoxybenzyl)spiro[chromane-2,4′-piperidine]-6-carboxamide (II-1);

1′-((1H-benzo[d]imidazol-2-yl)methyl)-N-hydroxyspiro[chromane-2,4′-piperidine]-6-carboxamide (II-2);

1′-(cyclohexanecarbonyl)-N-hydroxyspiro[chromane-2,4′-piperidine]-6-carboxamide (II-3);

N-hydroxy-1′-(4-methoxybenzoyl)spiro[chromane-2,4′-piperidine]-6-carboxamide (II-4);

N-hydroxy-1′-((4-methoxyphenyl)sulfonyl)spiro[chromane-2,4′-piperidine]-6-carboxamide (II-5);

1′-(cyclohexylsulfonyl)-N-hydroxyspiro[chromane-2,4′-piperidine]-6-carboxamide (II-6);

N6-hydroxy-N1′-phenylspiro[chromane-2,4′-piperidine]-1′,6-dicarboxamide (II-7);

1′-cyclohexyl-N-hydroxyspiro[chromane-2,4′-piperidine]-6-carboxamide (II-8); or

N-hydroxy-1′-(2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-1-carbonyl)spiro[chromane-2,4′-piperidine]-6-carboxamide (II-9).

24. A compound of claim 1 selected from:

N-hydroxy-1′-methyl-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-245);

N-hydroxy-1-methyl-3′,4′-dihydro-1′H-spiro[azepane-3,2′-naphthalene]-6′-carboxamide (I-246);

N-hydroxy-1-methyl-3′,4′-dihydro-1′H-spiro[azocane-3,2′-naphthalene]-6′-carboxamide (I-247);

N-hydroxy-1-methyl-2-oxo-3′,4′-dihydro-1′H-spiro[azepane-3,2′-naphthalene]-6′-carboxamide (I-248);

N-hydroxy-1-methyl-2-oxo-3′,4′-dihydro-1′H-spiro[azocane-3,2′-naphthalene]-6′-carboxamide (I-249);

N-hydroxy-1′-methyl-6′-oxo-3,4-dihydro-1H-spiro[naphthalene-2,3′-piperidine]-6-carboxamide (I-250);

N-hydroxy-1-methyl-7-oxo-3′,4′-dihydro-1′H-spiro[azepane-3,2′-naphthalene]-6′-carboxamide (I-251);

N-hydroxy-1-methyl-8-oxo-3′,4′-dihydro-1′H-spiro[azocane-3,2′-naphthalene]-6′-carboxamide (I-252);

N-hydroxy-1′-methyl-2′-oxospiro[chromane-2,3′-piperidine]-6-carboxamide (I-253);

N-hydroxy-1-methyl-2-oxospiro[azepane-3,2′-chromane]-6′-carboxamide (I-254);

N-hydroxy-1-methyl-2-oxospiro[azocane-3,2′-chromane]-6′-carboxamide (I-255);

N-hydroxy-1-methyl-2-oxospiro[piperidine-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-256);

N-hydroxy-1-methyl-2-oxospiro[azepane-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-257); or

N-hydroxy-1-methyl-2-oxospiro[azocane-3,2′-thiochromane]-6′-carboxamide 1′,1′-dioxide (I-258).

25. A pharmaceutical composition comprising a compound of claim 1 or claim 15 and a pharmaceutically acceptable carrier.

26. A method of treating a cancer selected from melanoma, cutaneous T-cell lymphoma, peripheral T-cell lymphoma, multiple myeloma, leukemia, lung cancer, ovarian cancer, breast cancer, prostate cancer, pancreatic cancer, hepatocellular cancer, renal cancer, squamous cell carcinoma, lymphoma, non-small cell lung cancer, myeloproliferative neoplasm, metastatic solid tumor, myelodysplastic syndrome, urothelial cancer, or myelofibrosis in a subject in need thereof, comprising administering to the subject an effective amount of a compound of claim 1 or claim 15 .

27. A method of treating a neurodegenerative disease selected from Alzheimer's, Huntington's, Parkinson's, Amyotrophic Lateral Sclerosis, Charcot-Marie-Tooth Disease, depression, Rett Syndrome, or spinal muscular atrophy in a subject in need thereof, comprising administering to the subject an effective amount of a compound of claim 1 or claim 15 .

28. A method of treating an immunological disease selected from rheumatoid arthritis, spondylitis arthritis, psoriatic arthritis, psoriasis, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel diseases, graft versus host disease, transplant rejection or fibrotic disease in a subject in need thereof, comprising administering to the subject an effective amount of a compound of claim 1 or claim 15 .

29. A method of inhibiting a histone deacetylase, comprising administering to a subject in need thereof a compound of claim 1 or claim 15 .

30. The method of claim 29 , wherein the compound inhibits a zinc-dependent histone deacetylase.

31. The method of claim 30 , wherein the compound inhibits the HDAC6 isozyme zinc-dependent histone deacetylase.

32. The method of claim 26 , wherein the lymphoma is selected from B-cell lymphoma or non-Hodgkin's lymphoma.

33. The method of claim 26 , wherein the leukemia is selected from acute myeloid leukemia and chronic lymphocytotic leukemia.