Methods of treating neuropathic pain with specific binding members for NGF
Specific binding members for Nerve Growth Factor (NGF), in particular anti-NGF antibody molecules, especially human antibody molecules, and especially those that neutralize NGF activity. Methods for using anti-NGF antibody molecules in diagnosis or treatment of NGF related disorders, including pain, asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, other diseases of airway inflammation, diabetic neuropathy, cardiac arrhythmias, HIV, arthritis, psoriasis and cancer.
1. A method of treating neuropathic pain, the method comprising administering an isolated specific binding member to a patient having neuropathic pain, wherein said isolated binding member comprises the 1252A5 VH domain of SEQ ID NO: 392 and the 1252A5 VL domain of SEQ ID NO: 397.
2. The method of claim 1 , wherein said isolated specific binding member comprises an scFv antibody molecule.
3. The method of claim 1 , wherein said isolated specific binding member comprises an antibody constant region.
4. The method of claim 1 , wherein said isolated specific binding member is an IgG4 antibody.
5. A method of treating neuropathic pain, the method comprising administering a composition to a patient having neuropathic pain, wherein said composition comprises an isolated specific binding member comprising the 1252A5 VH domain of SEQ ID NO: 392 and the 1252A5 VL domain of SEQ ID NO: 397.
6. The method of claim 5 , wherein the composition comprises a pharmaceutically acceptable excipient, vehicle or carrier.