Modulators of cystic fibrosis transmembrane conductance regulator
The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
1. A compound having formula I′ or formula II′:
wherein:
R X
is independently hydrogen, halo, CF 3 , C 1 -C 4 alkyl, or —OC 1 -C 4 alkyl; provided that both R X are not simultaneously hydrogen: or
the two R X , taken together form ring (a):
X is CH 2 , CF 2 CH 2 —CH 2 , or CF 2 —CF 2 ;
ring A is 3-7 membered monocyclic cycloalkyl ring;
Z is an electron withdrawing substituent;
q is 0- 3;
R is hydrogen or C 1 -C 6 aliphatic;
L is a linker selected from C(O) or SO 2 ;
p is 0 or 1; and
CA is a chiral auxiliary.