Cohesive bone composition
A cohesive bone composition is made from a moldable bone composition intermixed with a bone gel composition. The cohesive bone composition is made from human cadaver bone. A fluid can be added, the fluid may also be laden with cells.
1. A cohesive bone composition comprises:
a moldable bone composition mixed with a bone gel composition;
the moldable bone composition consisting of a mixture of cortical bone and cancellous bone, the cortical bone is formed in three portions, a mineralized shaving portion and a demineralized shaving portion and a mineralized powder portion, the cancellous bone is formed in a mineralized crushed cancellous portion, the portions are freeze-dried and mixed together to form a freeze-dried bone composition and when subjected to a fluid, the composition can be molded to a desired shape;
the bone gel composition consisting of cortical bone consists of cortical bone made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried, wherein a volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being twice the volume of the particles, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is placed in jars for later use; and
wherein a volume of moldable bone composition is mixed with a volume of the bone gel composition and wetted with a fluid to form the cohesive bone composition.
2. The cohesive bone composition of claim 1 wherein the moldable bone composition crushed cancellous bone is made from freeze-dried morselized cancellous ground to a size of 1000 to 1700 microns.
3. The cohesive bone composition of claim 1 wherein the moldable bone composition cortical bone powder is ground to 300 microns or less.
4. The cohesive bone composition of claim 1 wherein the moldable bone composition cortical shavings are long thin strips cut from cortical bone plates having a length of greater than 5 cm.
5. The cohesive bone composition of claim 4 wherein the moldable bone composition cortical shavings are strands having a length greater than 3 mm.
6. The cohesive bone composition of claim 1 wherein the moldable bone composition mixture has a percentage of demineralized cortical bone shaving portion by weight in the range of 15 to 25%.
7. The cohesive bone composition of claim 1 wherein the moldable bone composition mixture has a percentage of mineralized dry cortical bone shaving by volume in the range of 70 to 50%.
8. The cohesive bone composition of claim 1 wherein the moldable bone composition mixture has a percentage of mineralized dry cortical bone powder by volume in the range of 5 to 15%.
9. The cohesive bone composition of claim 1 wherein the moldable bone composition mixture has a percentage of dry crushed cancellous by volume in the range of 5 to 15%.
10. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of demineralized cortical bone shaving by weight of 20%.
11. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of dry mineralized cortical bone shaving by volume of 60%.
12. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of dry cortical bone powder by volume of 10%.
13. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of dry crushed cancellous by volume of 10%.
14. The cohesive bone composition of claim 1 wherein the moldable bone composition has a percentage of 20% demineralized cortical bone shaving, 60% dry mineralized cortical bone shaving, 10% dry cortical bone powder and 10% dry crushed cancellous.
15. The cohesive bone composition of claim 1 wherein the moldable bone composition formed as a freeze-dried material packaged in jars wherein the packaged mixture is stored at room temperature or frozen.
16. The cohesive bone composition of claim 1 wherein the bone gel composition cortical bone has the cut pieces having a width, a length and a thickness in the range of 1 to 4 mm.
17. The cohesive bone composition of claim 16 wherein the bone gel composition cortical bone pieces are ground to a particle size up to 125 microns.
18. The cohesive bone composition of claim 1 wherein the bone gel composition when placed in jars is then frozen.