IP Library Granted Patent US 10,351,883
Granted Patent B2
US 10,351,883 · App. 15/138,066 · Granted Jul 16, 2019

Compounds for increasing lipid synthesis and storage

Inventors: Concetta DiRusso (Lincoln, NE); Nishikant Wase (Lincoln, NE)
Assignee: NUtech Ventures
C12P7/6409C07C211/40C07C217/60C07C233/75C07D211/58C07D211/96C07D213/40C07D231/40C07D277/46C07D295/135C12N1/38C12P7/6463C12P19/04
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Quick Facts
Patent No.
US 10,351,883
App. No.
15/138,066
Granted
Jul 16, 2019
Kind
B2
Abstract

This invention relates to methods for increasing lipid accumulation and lipid production in cells. Methods of producing biofuel from cells and preparing nutraceuticals comprising lipids produced according to a method provided herein are also provided.

Claims (29)

1. A method of increasing lipid accumulation in an algal cell, comprising contacting the algal cell with an effective amount of a compound selected from the group consisting of:

or a salt thereof,

wherein the algal cell is selected from the group consisting of Chlamydomonas reinhardtii, Chlorella sorokiniana, Chlorella vulgaris , and Tetrachlorella altems.

2. A method of increasing lipid accumulation in an algal cell, comprising contacting the algal cell with an effective amount of a compound selected from the group consisting of:

or a salt thereof,

wherein the algal cell is selected from the group consisting of:

Chlamydomonas reinhardtii;

Chlorella sorokiniana;

Tetrachlorella alterans;

C. protothecoides;

C. vulgaris ; and

Nannochloropsis sp.

3. The method of claim 2 , wherein the algal cell is selected from the group consisting of Chlamydomonas reinhardtii, Chlorella sorokiniana, Chlorella vulgaris , and Tetrachlorella altems.

4. The method of claim 2 , wherein the compound is selected from the group consisting of:

or a salt thereof,

wherein the algal cell is selected from the group consisting of:

Chlamydomonas reinhardtii;

Chlorella sorokiniana;

Tetrachlorella alterans;

C. protothecoides;

C. vulgaris ; and

Nannochloropsis sp.

5. The method of claim 4 , wherein the algal cell is selected from the group consisting of Chlamydomonas reinhardtii, Chlorella sorokiniana, Chlorella vulgaris , and Tetrachlorella altems.

6. The method of claim 5 , wherein the compound is:

or a salt thereof.

7. The method of claim 5 , wherein the compound is:

or a salt thereof.

8. The method of claim 5 , wherein the compound is:

or a salt thereof.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 19, 2017
From: DILLER, THOMAS; SUTTON, BETHANY; UPDYKE, TIMOTHY; HANSON, GEORGE
To: INVITROGEN CORPORATION
Reel/Frame 041018/0034 →
MERGER AND CHANGE OF NAME Recorded Jan 19, 2017
From: INVITROGEN CORPORATION; LIFE TECHNOLOGIES CORPORATION
To: LIFE TECHNOLOGIES CORPORATION
Reel/Frame 041018/0108 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 2, 2016
From: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
To: NUTECH VENTURES
Reel/Frame 039623/0348 →
CONFIRMATORY LICENSE Recorded May 24, 2016
From: UNIVERSITY OF NEBRASKA, LINCOLN
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 038805/0198 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2016
From: DIRUSSO, CONCETTA; WASE, NISHIKANT
To: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
Reel/Frame 038635/0722 →
Continuity (2)
Provisional Application 62152717 · Apr 24, 2015
Related Publication 20160312253A1 · Oct 27, 2016