Methods and compositions for preventing opioid abuse
Abuse-resistant opioid compounds, drug delivery systems, pharmaceutical compositions comprising an opioid covalently bound to a chemical moiety are provided. Methods of delivering an active ingredient to a subject and methods of preventing opioid abuse are also provided.
1. An abuse-resistant opioid compound represented by Formula I:
O-X n .•T c (I)
wherein,
O is an opioid selected from the group consisting of oxycodone and oxymorphone;
each X is an independent chemical moiety that is safe for human consumption having a hydrolyzable point of linkage to O though oxygen of an enol tautomer of O, such that hydrolysis releases activated opioid, and X consists of α-hydroxy acid;
T is a pharmaceutically acceptable salt;
c is from 0 to 5; and
n is from 1 to 10.
2. The abuse-resistant opioid compound of claim 1 , wherein X consists of lactic acid, mandelic acid, malic acid, or tartaric acid.
3. A pharmaceutical composition, comprising:
an abuse-resistant opioid compound; and
at least one pharmaceutical additive,
wherein the abuse-resistant opioid compound is represented by Formula I:
O-X n .•T c (I)
wherein,
O is an opioid selected from the group consisting of oxycodone and oxymorphone;
each X is an independent chemical moiety that is safe for human consumption having a hydrolyzable point of linkage to O though oxygen of an enol tautomer of O such that hydrolysis releases activated opioid, and X consists of α-hydroxy acid;
T is a pharmaceutically acceptable salt;
c is from 0 to 5; and
n is from 1 to 10.
4. The pharmaceutical composition of claim 3 , wherein X consists of lactic acid, mandelic acid, malic acid, or tartaric acid.
5. The abuse-resistant opioid compound of claim 1 , wherein the abuse-resistant compound is selected from the group consisting of: