Methods and devices for paranasal sinus delivery
Described herein are methods and devices for delivering a drug to the frontal sinus system. An inflatable implant is positioned within the frontal sinus system using an anchoring means secured within the frontal sinus cavity. A drug-containing fluid is released directly into the frontal sinus drainage system.
1. A frontal sinus drug delivery system comprising:
a catheter comprising an elongate hollow shaft formed from a cuttable material and having a balloon mounted on a distal region thereof, wherein the hollow shaft contains a one-way valve therein and a fluid port located in the hollow shaft that provides a fluid passageway to an interior portion of the balloon from the hollow shaft, wherein the balloon has a plurality of ports formed therein;
a fluid containing a pharmaceutical agent configured to be delivered to the interior of the balloon via the hollow shaft;
a moveable core extending part way through the hollow shaft in the proximal direction and extending distally with respect to a distal tip of the catheter, wherein a distal end of the moveable core has a plurality of retention wings, wherein the moveable core frictionally engages with the elongate hollow shaft and wherein the distance between the retention wings and the balloon is adjustable; and
an elongate sheath containing the catheter, balloon, and retention wings.
2. The frontal sinus drug delivery system of claim 1 , wherein the one-way valve comprises a circular valve and the moveable core extends through the circular valve.
3. The frontal sinus drug delivery system of claim 2 , wherein the circular valve frictionally engages with the moveable core.
4. The frontal sinus drug delivery system of claim 1 , wherein the distal tip of the catheter frictionally engages with the moveable core.
5. The frontal sinus drug delivery system of claim 1 , wherein the pharmaceutical agent comprises an anti-scarring agent.
6. The frontal sinus drug delivery system of claim 1 , wherein the pharmaceutical agent comprises a tissue proliferation agent.
7. The frontal sinus drug delivery system of claim 1 , wherein the balloon comprises a plurality of lobes.
8. A method of using the frontal sinus drug delivery system of claim 1 comprising:
advancing the elongate sheath containing the catheter, balloon, and retention wings within an anatomical space of the frontal sinus system to a desired location;
proximally retracting the sheath relative to the catheter to deploy the balloon and the retention wings;
adjusting the distance between the retention wings and the balloon by manipulating the catheter; and
inflating the balloon with the fluid containing a pharmaceutical agent.
9. The method of claim 8 , wherein the retention wings are deployed in the frontal sinus cavity.
10. The method of claim 9 , wherein the balloon is deployed in a frontal drainage pathway.
11. The method of claim 8 , further comprising cutting the catheter and moveable core.