IP Library Granted Patent US 10,029,002
Granted Patent B2
US 10,029,002 · App. 15/142,745 · Granted Jul 24, 2018

Methods and compositions for reducing the environmental impact of animal waste

Inventors: David M. Anderson (Rockville, MD); Sergey Podkovyrov (Gaithersburg, MD); Yuefang Huang (Highland, MD); Kurt Schuster (Salisbury, MD); Jon Edward Ferrel (Frankfort, IN)
Assignee: ELANCO US INC.
A61K38/465A23K20/189A23K50/30A23K50/60A23K50/75C12N9/16C12Y301/03001A23V2002/00
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Quick Facts
Patent No.
US 10,029,002
App. No.
15/142,745
Granted
Jul 24, 2018
Kind
B2
Abstract

Methods for reducing the environmental impact of animal waste are described. In particular embodiments, the methods comprise administering to an animal an enzyme, such as alkaline phosphatase, that is effective to reduce the amount of a detrimental compound, such as ammonia or phosphorous, that is present in or released from animal waste. Also provided is a method for increasing phosphorus digestion in an animal. Compositions suitable for use in such methods are also described.

Claims (22)

1. A method for reducing the environmental impact of animal waste, comprising orally administering to an animal a composition comprising an effective amount of an alkaline phosphatase comprising amino acids 33 to 572 of SEQ ID NO:1, wherein said alkaline phosphatase comprises serine at position 102 and reduces the amount of one or more detrimental compounds present in or released from animal waste, and one or more orally acceptable carriers, thereby reducing the environmental impact of animal waste.

2. The method of claim 1 , wherein said detrimental compound is ammonia or phosphorous.

3. The method of claim 1 , wherein said animal is a young animal.

4. The method of claim 1 , wherein said animal is a chicken, a turkey, a swine, or a cow.

5. The method of claim 1 , wherein the alkaline phosphatase is administered during one or more of the starter phase, the grower phase, and/or the finisher phase.

6. The method of claim 1 , wherein the alkaline phosphatase is formulated in an animal feed or an animal feed additive.

7. The method of claim 1 , wherein one or more additional active Ingredients are administered to said animal.

8. A composition suitable for oral administration to an animal comprising: an effective amount of an alkaline phosphatase comprising amino acids 33 to 572 of SEQ ID NO:1, wherein said alkaline phosphatase comprises serine at position 102 and reduces the amount of one or more detrimental compounds present in or released from animal waste, and one or more orally acceptable carriers.

9. The composition of claim 8 , wherein said detrimental compound is ammonia or phosphorous.

10. The composition of claim 8 , wherein said animal is a young animal.

11. The composition of claim 8 , wherein said animal is a chicken, a turkey, a swine, or a cow.

12. The composition of claim 8 , wherein said alkaline phosphatase is formulated to be orally administered during one or more of the starter phase, the grower phase, and/or the finisher phase.

13. The composition of claim 8 , wherein said alkaline phosphatase is formulated in an animal feed or in an animal feed additive.

14. The composition of claim 8 , wherein said composition comprises one or more additional active ingredients.

15. A method for increasing phosphorus digestion in an animal, comprising orally administering to said animal a composition comprising an effective amount of an alkaline phosphatase comprising amino acids 33 to 572 of SEQ ID NO: 1, wherein said alkaline phosphatase comprises serine at position 102, and reduces the amount of phosphorus present in or released from animal waste, and one or more orally acceptable carriers, thereby increasing digestion of phosphorus by said animal.

16. The method of claim 15 , wherein said animal is a young animal.

17. The method of claim 15 , wherein said animal is a chicken, a turkey, a swine, or a cow.

18. The method of claim 15 , wherein said alkaline phosphatase is administered during one or more of the starter phase, the grower phase, and/or the finisher phase.

19. The method of claim 15 , wherein said alkaline phosphatase is formulated in an animal feed or in an animal feed additive.

20. A method for reducing the amount of one or more detrimental compounds present in or released from animal waste, increasing animal feed conversion rate, increasing animal feed efficiency, and/or increasing animal growth rate, comprising orally administering to an animal an effective amount of a composition of claim 8 .

21. An alkaline phosphatase comprising amino acids 33 to 572 of SEQ ID NO:1, wherein said alkaline phosphatase comprises serine at position 102 and reduces the amount of one or more detrimental compounds present in or released from animal waste when administered orally to an animal.

22. The alkaline phosphatase of claim 21 , wherein said detrimental compound is ammonia or phosphorous.

Assignments (7)
ASSIGNMENT OF SECURITY INTEREST IN PATENT RIGHTS, RECORDED ON AUGUST 3, 2020, AT REEL/FRAME 053388/0967 Recorded Dec 3, 2025
From: GOLDMAN SACHS BANK USA, AS RETIRING COLLATERAL AGENT
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR COLLATERAL AGENT
Reel/Frame 073816/0021 →
PARTIAL RELEASE OF SECURITY INTEREST Recorded May 25, 2022
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: ELANCO US INC.
Reel/Frame 060586/0980 →
SECURITY INTEREST Recorded Aug 3, 2020
From: ELANCO US INC.
To: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
Reel/Frame 053388/0967 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 23, 2018
From: ELI LILLY AND COMPANY
To: ELANCO US INC.
Reel/Frame 044702/0782 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2016
From: CHEMGEN CORPORATION
To: ELI LILLY AND COMPANY
Reel/Frame 038595/0166 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2016
From: ANDERSON, DAVID M; PODKOVYROY, SERGEY; HUANG, YUEFANG; SCHUSTER, KURT
To: CHEMGEN CORPORATION
Reel/Frame 038439/0289 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2016
From: FERREL, JON EDWARD
To: ELI LILLY AND COMPANY
Reel/Frame 038439/0366 →
Continuity (3)
Continuation 14347705
Provisional Application 61599729 · Feb 16, 2012
Related Publication 20160235823A1 · Aug 18, 2016