IP Library Granted Patent US 9,926,279
Granted Patent B2
US 9,926,279 · App. 15/145,232 · Granted Mar 27, 2018

Process for the preparation of 3-haloalkylpyrazoles

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Quick Facts
Patent No.
US 9,926,279
App. No.
15/145,232
Granted
Mar 27, 2018
Kind
B2
Abstract

The present invention provides a process for the preparation of a compound of formula I: wherein R 1 is C 1 -C 4 haloalkyl; R 2 is optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; and R 3 is methyl or ethyl; comprising reacting a compound of formula IV: wherein R 1 , R 2 and R 3 are as defined for the compound of formula I; with an alkylating agent in the presence of an amide.

Claims (13)

1. A process for the preparation of a compound of formula I:

wherein R 1 is C 1 -C 4 haloalkyl;

R 2 is optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl; and

R 3 is methyl or ethyl;

comprising

b1. reacting a compound of formula II:

wherein R 1 and R 2 are as defined for the compound of formula I; with an alkylating agent to produce a mixture comprising a compound of formula I and a compound of formula IV

wherein R 1 , R 2 and R 3 are as defined for the compound of formula I; and

b2. reacting the mixture from b1. with an alkylating agent in the presence of an amide.

2. A process according to claim 1 , wherein

R 1 is difluoromethyl or trifluoromethyl;

R 2 is C 1 -C 6 alkyl; and

R 3 is methyl.

Assignments (2)
MERGER AND CHANGE OF NAME Recorded Mar 14, 2025
From: SYNGENTA PARTICIPATIONS AG; SYNGENTA PARTICIPATIONS AG
To: SYNGENTA CROP PROTECTION AG
Reel/Frame 070516/0868 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 7, 2016
From: WANG, LINHUA; SHETH, RITESH BHARAT
To: SYNGENTA PARTICIPATIONS AG
Reel/Frame 039097/0298 →