Chitosan-enhanced electrospun fiber compositions
A composition may comprise a plurality of polymeric electrospun fiber fragments, and a carrier medium comprising an effective amount of chitosan. Such a composition may further include a plurality of polymeric electrospun fiber fragment clusters. A kit may comprise a first component of a plurality of polymeric electrospun fiber fragments, and a second component of a carrier medium comprising an effective amount of chitosan. A method of treatment may comprise injecting into a portion of a body a composition which may comprise a plurality of polymeric electrospun fiber fragments, and a carrier medium comprising an effective amount of chitosan. The treatment may be directed to one or more of joint inflammation, osteoarthritis, a tissue injury, a muscle tear, a ligament tear, a tendon tear, a void, incontinence, an aneurysm, and a tumor.
1. A composition comprising:
a plurality of synthetic polymeric electrospun fiber fragments; and
an aqueous carrier medium comprising an effective amount of chitosan;
wherein the plurality of synthetic polymeric electrospun fiber fragments are present in an amount from about 1 fragment per mm 3 to about 100,000 fragments per mm 3 ; and
wherein the effective amount of chitosan to the aqueous carrier medium is from about 0.0001 wt % to about 5 wt %.
2. The composition of claim 1 , further comprising a plurality of synthetic polymeric electrospun fiber fragment clusters.
3. The composition of claim 2 , wherein the plurality of synthetic polymeric electrospun fiber fragment clusters have, independently, an average length of about 1 μm to about 1000 μm, an average width of about 1 μm to about 1000 μm, and an average height of about 1 μm to about 1000 μm.
4. The composition of claim 2 , wherein a weight percent of the plurality of synthetic polymeric electrospun fiber fragments and the plurality of synthetic polymeric electrospun fiber fragment clusters to the aqueous carrier medium is about 0.0001 wt % to about 10 wt %.
5. The composition of claim 1 , wherein the plurality of synthetic polymeric electrospun fiber fragments have, independently, an average length of about 1 μm to about 1000 μm, and an average diameter of about 0.1 μm to about 10 μm.
6. The composition of claim 1 , further comprising at least one biological cell selected from the group consisting of an autologous cell, a syngeneic cell, an allogeneic cell, a differentiated cell, a stem cell, a multipotent stem cell, a pluripotent stem cell, an induced pluripotent stem cell, a totipotent stem cell, a bone marrow-derived stem cell, a cord blood stem cell, a mesenchymal cell, an embryonic stem cell, platelet-rich plasma, stromal vascular fraction, and combinations thereof.
7. A kit comprising:
a first component comprising a plurality of synthetic polymeric electrospun fiber fragments; and
a second component comprising an aqueous carrier medium comprising an effective amount of chitosan;
wherein the plurality of synthetic polymeric electrospun fiber fragments are present in an amount from about 1 fragment per mm 3 to about 100,000 fragments per mm 3 ; and
wherein the effective amount of chitosan to the aqueous carrier medium is from about 0.0001 wt % to about 5 wt %.
8. The kit of claim 7 , wherein the first component further comprises a plurality of synthetic polymeric electrospun fiber fragment clusters.
9. A method of treatment comprising injecting, into a portion of a body, the composition of claim 1 .
10. The method of claim 9 , wherein the composition further comprises a plurality of synthetic polymeric electrospun fiber fragment clusters.
11. The method of claim 9 , wherein the portion of the body comprises one or more of a portion of cartilage, a meniscus, a ligament, a tendon, a joint, a muscle, a portion of skin, a sphincter, and a blood vessel.