IP Library Granted Patent US 10,059,684
Granted Patent B2
US 10,059,684 · App. 15/146,668 · Granted Aug 28, 2018

Process to extract and purify Δ

Inventors: Lekhram Changoer (Ridderkerk, NL); Cornelis Herman Michel Van Der Loo (Groningen, NL); Erik Keller (Adorp, NL)
Assignee: Axim Biotechnologies, Inc.
C07D311/80
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Quick Facts
Patent No.
US 10,059,684
App. No.
15/146,668
Granted
Aug 28, 2018
Kind
B2
Abstract

Δ 9 -THC acid is extracted from cannabis flowers using a first organic solvent, then separated using a second aqueous solvent. Δ 9 -THC acid is converted to Δ 9 -THC carboxylic salt before being extracted by a third organic solvent and converted back to Δ 9 -THC carboxylic acid. Using a solvent swap, Δ 9 -THC carboxylic acid is decarboxylated and extracted again with an organic solvent prior to purification to give Δ 9 -THC.

Claims (5)

1. A method for producing A 9 -THC consisting essentially of:

extracting A 9 -THC carboxylic acid from cannabis flowers using heptane to obtain a heptane extract;

filtering the heptane extract to remove solid plant matter from the cannabis flowers; and

separating the A 9 -THC carboxylic acid from the heptane extract using sodium chloride water and then adjusting the pH to a pH range of 13.2 to 13.4 using magnesium chloride;

wherein the extracting of the A 9 -THC carboxylic acid from the heptane results in the formation of three layers consisting of a first organic layer, a second oily layer, and third aqueous layer.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 26, 2020
From: AXIM BIOTECHNOLOGIES, INC.
To: APIRX PHARMACEUTICAL USA, LLC
Reel/Frame 052752/0519 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 31, 2016
From: CHANGOER, LEKHRAM; VAN DER LOO, CORNELIS HERMAN MICHEL; KELLER, ERIK
To: AXIM BIOTECHNOLOGIES, INC.
Reel/Frame 038851/0661 →
Continuity (2)
Provisional Application 62158075 · May 7, 2015
Related Publication 20160326130A1 · Nov 10, 2016
Cited By (1)
US 12,286,415