Tissue substitute materials and methods for tissue repair
Non-woven graft materials for use in specialized surgical procedures such as neurosurgical procedures, methods for making the non-woven graft materials, and methods for repairing tissue such as neurological tissue using the non-woven graft materials are disclosed. More particularly, disclosed are non-woven graft materials including at least two distinct fiber compositions composed of different polymeric materials, methods for making the non-woven graft materials and methods for repairing tissue in an individual in need thereof using the non-woven graft materials.
1. A resorbable non-woven graft material consisting of a single layer comprising:
a first electrospun non-woven fiber composition, wherein the first electrospun non-woven fiber composition consists of poly (glycolic acid) and
a second electrospun non-woven fiber composition, wherein the second electrospun non-woven fiber composition comprises poly(lactide-co-caprolactone),
wherein the first electrospun non-woven fiber composition and the second electrospun non-woven fiber composition comprise different polymers, and
wherein the first electrospun non-woven fiber composition and the second electrospun non-woven fiber composition are commingled throughout a thickness of the resorbable non-woven graft material.
2. The non-woven graft material of claim 1 , wherein the first electrospun non-woven fiber composition to the second electrospun non-woven fiber composition ratio ranges from about 10:1 to about 1:10.
3. The non-woven graft material of claim 1 , comprising a mean pore size of from about 10 μm 2 to about 10,000 μm 2 .
4. The non-woven graft material of claim 1 , wherein at least one of the first electrospun non-woven fiber composition and the second electrospun non-woven fiber composition comprise a mean fiber diameter of less than 5 μm.
5. The non-woven graft material of claim 1 , wherein the first electrospun non-woven fiber composition and the second electrospun non-woven fiber composition are uniformly distributed throughout the material.
6. The non-woven graft material of claim 1 , wherein the first electrospun non-woven fiber composition and the second electrospun non-woven fiber composition are independently distributed in a pattern throughout the material.
7. The non-woven graft material of claim 1 , further comprising at least one projection arising from a surface of the non-woven graft material, at least one indentation in a surface of a non-woven graft material, and combinations thereof.
8. The non-woven graft material of claim 1 , further comprising:
a plurality of projections arising from a surface of the non-woven graft material, wherein the plurality of projections are randomly distributed on the surface of the non-woven graft material; and
a plurality of indentations in the surface of the non-woven graft material, wherein the plurality of indentations are randomly distributed on the surface of the non-woven graft material.
9. The non-woven graft material of claim 8 , wherein at least one of the plurality of indentations comprises a gradual gradient.
10. The non-woven graft material of claim 8 , wherein the plurality of indentations comprise a substantially uniform depth.
11. The non-woven graft material of claim 8 , wherein at least one of the plurality of projections comprises a gradual gradient.
12. The non-woven graft material of claim 8 , wherein the plurality of projections comprise a substantially uniform depth.
13. A resorbable non-woven graft material consisting of a single layer comprising:
a first electrospun non-woven fiber composition, wherein the first electrospun non-woven fiber composition consists of poly(glycolic acid); and
a second electrospun non-woven fiber composition, wherein the second electrospun non-woven fiber composition consists of poly(lactide-co-caprolactone),
wherein the first electrospun non-woven fiber composition and the second electrospun non-woven fiber composition are commingled throughout a thickness of the resorbable non-woven graft material.
14. The non-woven graft material of claim 13 , further comprising:
a plurality of projections arising from a surface of the non-woven graft material, wherein the plurality of projections are randomly distributed on the surface of the non-woven graft material; and
a plurality of indentations in the surface of the non-woven graft material, wherein the plurality of indentations are randomly distributed on the surface of the non-woven graft material.
15. The non-woven graft material of claim 14 , wherein at least one of the plurality of indentations comprises a gradual gradient.
16. The non-woven graft material of claim 14 , wherein the plurality of indentations comprise a substantially uniform depth.
17. The non-woven graft material of claim 14 , wherein at least one of the plurality of projections comprises a gradual gradient.
18. The non-woven graft material of claim 14 , wherein the plurality of projections comprise a substantially uniform depth.
19. A resorbable non-woven graft material consisting of a single layer comprising:
a first electrospun non-woven fiber composition, wherein the first electrospun non-woven fiber composition comprises poly(glycolic acid);
a second electrospun non-woven fiber composition, wherein the second electrospun non-woven fiber composition comprises poly(lactide-co-caprolactone),
wherein the first electrospun non-woven fiber composition and the second electrospun non-woven fiber composition comprise different polymers, and
wherein the first electrospun non-woven fiber composition and the second electrospun non-woven fiber composition are commingled throughout a thickness of the resorbable non-woven graft material using an electrospinning process;
a plurality of projections arising from a surface of the non-woven graft material, wherein the plurality of projections are randomly distributed in an uncontrolled configuration on the surface of the non-woven graft material; and
a plurality of indentations in the surface of the non-woven graft material, wherein the plurality of indentations are randomly distributed in an uncontrolled configuration on the surface of the non-woven graft material.
20. The non-woven graft material of claim 19 , wherein the first electrospun non-woven fiber composition and the second electrospun non-woven fiber composition are independently distributed in a pattern throughout the material.