Ion guide or filters with selected gas conductance
Certain embodiments described herein are directed to rod assemblies such as, for example, quadrupole, hexapole and octupole rod assemblies. In some instances, the rod assemblies include at least one pole comprising an integral fluid path configured to fluidically couple an ion volume formed by the assembly to an outer volume of the assembly to remove fluid within the ion volume to the outer volume while containing ions of a selected mass-to-charge range.
1. A mass spectrometer comprising:
a sample introduction device;
an ionization device fluidically coupled to the sample introduction device;
a mass analyzer fluidically coupled to the ionization device, the mass analyzer comprising a multipole assembly comprising a plurality of poles, in which at least one of the poles of the multipole assembly comprises an integral fluid path that fluidically couples an ion volume formed by the poles of the multipole assembly to an outer volume of the multipole assembly, in which the integral fluid path is configured to decrease a pressure of a second section of the multipole assembly downstream of a first section of the multipole assembly comprising the integral fluid path by drawing gas from the ion volume into the outer volume, in which the first section and the second section are electrically coupled to each other to permit a field to be provided by the multipole assembly to transmit ions through the first section and the second section of the multipole assembly; and
a detector fluidically coupled to the mass analyzer.
2. The mass spectrometer of claim 1 , further comprising at least one pump fluidically coupled to the integral fluid path.
3. The mass spectrometer of claim 2 , in which the first section comprises a width at a first end of the first section that is less than a width at a second end of the first section.
4. The mass spectrometer of claim 3 , further comprising an interface between the ionization device and the multipole assembly, in which the first end of the first section of the pole comprising the integral fluid path is configured to insert into the interface.
5. The mass spectrometer of claim 4 , in which the interface is configured as a skimmer cone.
6. The mass spectrometer of claim 1 , in which at least two opposite poles of the multipole assembly each comprise an integral fluid path that fluidically couples the ion volume formed by the poles of the multipole assembly to the outer volume of the multipole assembly.
7. The mass spectrometer of claim 6 , further comprising at least one pump fluidically coupled to each of the integral fluid paths.
8. The mass spectrometer of claim 7 , in which the opposites poles comprising the integral fluid paths comprise two or more sections electrically coupled to each other.
9. The mass spectrometer of claim 8 , further comprising an interface between the ionization device and the multipole assembly, in which the first end of each of the opposite poles is configured to insert into the interface.
10. The mass spectrometer of claim 9 , in which the interface is configured as a skimmer cone.
11. The mass spectrometer of claim 1 , in which the integral fluid path is arranged at a non-orthogonal angle to an ion travel axis of the multipole assembly.
12. The mass spectrometer of claim 1 , in which the multipole assembly is configured as a quadrupole assembly.
13. The mass spectrometer of claim 12 , in which each of first, second, third and fourth poles of the quadrupole assembly comprises a first section comprising an integral fluid path that fluidically couples the ion volume formed by the poles of the quadrupole assembly to an outer volume of the quadrupole assembly.
14. The mass spectrometer of claim 13 , in which each integral fluid path is arranged at a non-orthogonal angle to an ion travel axis of the quadrupole assembly.
15. The mass spectrometer of claim 1 , in which the multipole assembly is configured as a hexapole assembly.
16. The mass spectrometer of claim 15 , in which each of first, second, third, fourth, fifth and sixth poles of the hexapole assembly comprises a first section comprising an integral fluid path that fluidically couples the ion volume formed by the poles of the hexapole assembly to an outer volume of the hexapole assembly.
17. The mass spectrometer of claim 16 , in which each integral fluid path is arranged at a non-orthogonal angle to an ion travel axis of the hexapole assembly.
18. The mass spectrometer of claim 1 , in which the multipole assembly is configured as an octupole assembly.
19. The mass spectrometer of claim 18 , in which each of first, second, third, fourth, fifth, sixth, seventh and eighth poles of the octupole assembly comprises a first section comprising an integral fluid path that fluidically couples the ion volume formed by the poles of the octupole assembly to an outer volume of the octupole assembly.
20. The mass spectrometer of claim 19 , in which each integral fluid path is arranged at a non-orthogonal angle to an ion travel axis of the octupole assembly.
21. The mass spectrometer of claim 11 , in which the integral fluid path of the first section comprises a plurality of individual apertures each comprising a respective serration, in which each of the plurality of individual apertures in the first section comprises a different size from other apertures in the first section.