Methods and devices for the detection of hypopnoea
Automated methods provide hypopnea detection for determining a hypopnea event and/or a severity of a hypopnea event. In some embodiments, a calculated short-term variance of a measured respiratory flow signal are compared to first and second proportions of a calculated long-term variance of the measured flow signal. A detection of the hypopnea may be indicated if the first measure falls below and does not exceed a range of the first and second proportions during a first time period. In some embodiments, a hypopnea severity measure is determined by automated measuring of an area bounded by first and second crossings of a short-term measure of ventilation and a proportion of a long-term measure. The detection methodologies may be implemented for data analysis by a specific purpose computer, a detection device that measures a respiratory airflow or a respiratory treatment apparatus that provides a respiratory treatment regime based on the detected hypopneas.
1. A hypopnea detection apparatus comprising:
a controller having at least one processor to access data representing a measured flow of breathable gas, the controller being further configured to control:
a detection of an hypopnea event from the data representing the measured flow of breathable gas;
a determination of a measure indicative of obstruction coincident with the hypopnea event in the data representing the measured flow; and
a classification of the detected hypopnea event as obstructive or central based on the determining of the measure indicative of obstruction,
wherein the determination detects partial obstruction and the classification comprises scoring an obstructive hypopnea event, and
wherein the controller is further configured to detect an absence of a breath coincident with a further detected hypopnea event and to refrain from scoring the further detected hypopnea event based on the detected absence of a breath.
2. The apparatus of claim 1 further comprising:
a flow generator configured to produce a breathable gas for a patient at a pressure above atmospheric pressure; and
a flow sensor,
wherein the controller is further configured to measure the flow of breathable gas with the flow sensor and to control the flow generator to produce the breathable gas according to a pressure therapy regime based on the classification of the detected hypopnea event.
3. A hypopnea detection apparatus comprising:
a controller having at least one processor to access data representing a measured flow of breathable gas, the controller being further configured to control:
a detection of an hypopnea event from the data representing the measured flow of breathable gas;
a determination of a measure indicative of obstruction coincident with the hypopnea event in the data representing the measured flow; and
a classification of the detected hypopnea event as obstructive or central based on the determining of the measure indicative of obstruction,
wherein the determination detects partial obstruction and the classification comprises scoring an obstructive hypopnea event, and
wherein the controller is further configured to detect a patency condition of a respiratory airway coincident with a further detected hypopnea event and to refrain from scoring the further detected hypopnea event based on the detected patency condition of the respiratory airway.
4. A method for detecting a hypopnea comprising:
in a controller having at least one processor, the controller configured to receive a signal from a sensor indicating a measured flow of breathable gas;
accessing data representing the measured flow of breathable gas;
detecting a hypopnea event from the data representing the measured flow of breathable gas;
determining a measure indicative of obstruction coincident with the hypopnea event in the data representing the measured flow;
classifying the detected hypopnea event as obstructive or central based on the determining of the measure indicative of obstruction,
wherein the determining comprises detecting partial obstruction and the classifying comprises scoring an obstructive hypopnea event, and
the method further comprising detecting, in the controller, an absence of a breath coincident with a′further detected hypopnea event and refraining from scoring the further detected hypopnea event based on the detected absence of a breath.
5. The method of claim 4 further comprising:
producing, with a flow generator, a breathable gas for a patient at a pressure above atmospheric pressure; and
measuring, with the controller, the flow of breathable gas with the sensor, the sensor comprising a flow sensor; and
controlling, with the controller, the flow generator to produce the breathable gas according to a pressure therapy regime based on the classifying of the detected hypopnea event.
6. A method for detecting a hypopnea comprising:
in a controller having at least one processor, the controller configured to receive a signal from a sensor indicating a measured flow of breathable gas;
accessing data representing the measured flow of breathable gas;
detecting a hypopnea event from the data representing the measured flow of breathable gas;
determining a measure indicative of obstruction coincident with the hypopnea event in the data representing the measured flow;
classifying the detected hypopnea event as obstructive or central based on the determining of the measure indicative of obstruction,
wherein the determining comprises detecting partial obstruction and the classifying comprises scoring an obstructive hypopnea event, and
the method further comprising detecting a patency condition of a respiratory airway coincident with a further detected hypopnea event and refraining from scoring the further detected hypopnea event based on the detected patency condition of the respiratory airway.
7. A method for detecting a hypopnea from a measured flow of breathable gas, the method comprising:
in a controller having at least one processor, the controller configured to receive a signal from a sensor indicating the measured flow of breathable gas;
accessing data representing the measured flow of breathable gas;
determining a long-term measure of ventilation from the measured flow;
determining a short-term measure of ventilation from the measured flow;
determining a threshold as a proportion of the long-term measure of ventilation;
measuring an area bounded by first and second crossings of the short-term measure of ventilation and the threshold; and
detecting the hypopnea with the measured area.
8. The method of claim 7 wherein the measuring the area comprises integrating a difference between the threshold and the short-term measure of ventilation during a time period from when the short-term measure falls below the threshold to when the short-term measure exceeds the threshold.
9. The method of claim 7 , wherein the controller is configured to measure the area by adding a plurality of sample differences during a time period from when the short-term measure falls below the threshold to when the short-term measure exceeds the threshold, wherein each sample difference is a difference between a sample of the threshold and a sample of the short-term measure of ventilation.
10. The method of claim 7 , further comprising a flow sensor and wherein the controller is further configured to determine the measured flow of breathable gas with the flow sensor.
11. The method of claim 10 , further comprising:
a flow generator configured to produce a breathable gas for a patient at a pressure above atmospheric pressure; wherein the controller is further configured to control the flow generator to produce the breathable gas according to a pressure therapy regime based on the detected hypopnea.
12. A non-transitory processor-readable medium having stored thereon processor-executable instructions which, when executed by a processor, cause the processor to detect a hypopnea, the processor-executable instructions comprising:
instructions to receive, with the processor, a measured flow of breathable gas;
instructions to determine a long-term measure of ventilation based on the measured flow;
instructions to determine a short-term measure of ventilation based on the measured flow;
instructions to determine a threshold as a proportion of the long-term measure of ventilation;
instructions to measure an area bounded by first and second crossings of the short-term measure of ventilation and the threshold; and
instructions to detect the hypopnea with the measured area.
13. The medium of claim 12 wherein the instructions to measure the area comprise instructions to integrate a difference between the threshold and the short-term measure of ventilation during a time period from when the short term measure falls below the threshold to when the short term measure exceeds the threshold.
14. The medium of claim 13 , wherein the instructions to measure the area comprise instructions to add a plurality of sample differences during a time period from when the short-term measure falls below the threshold to when the short-term measure exceeds the threshold, wherein each sample difference is a difference between a sample of the threshold and a sample of the short-term measure of ventilation.
15. The medium of claim 13 wherein the processor-executable instructions comprise instructions to control a flow generator to produce a breathable gas according to a pressure therapy regime based on the detected hypopnea.