IP Library Patent Application 15157876
Patent Application
App. No. 15/157,876

SKIN ENGAGING MEMBER COMPRISING A CYCLOHEXANECARBOXAMIDE DERIVATIVE

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Quick Facts
Patent No.
US None
App. No.
15/157,876
Abstract

A skin engaging member suitable for use in a hair removal device, said skin engaging member comprising cyclohexanecarboxamide structure which provides a cooling sensation when used at varying levels.

Claims (63)

1 . A skin engaging member, said skin engaging member comprising:

a. a matrix comprising at least one of: a water soluble polymer, an emollient, a soap base, and a mixture thereof;

b. a cyclohexanecarboxamide having a formulation selected from the group consisting of:

R 1 is selected from H, alkyl, amino alkyl, alkoxy;

Q=H 2 , O, —OR 1 , —N(R 1 ) 2 , —OPO(OR 1 ) x , —PO(OR 1 ) x , —P(OR 1 ) x where x=1-2;

V=NR 1 , O, —OPO(OR 1 ) x , —PO(OR 1 ) x , —P(OR 1 ) x where x=1-2;

W=H 2 , O;

X, Y=independently selected from H, aryl, naphthyl for n=0;

X, Y=aliphatic CH 2 or aromatic CH for n≧1 and Z is selected from aliphatic CH 2 , aromatic CH, or heteroatom;

A=lower alkoxy, lower alkylthio, aryl, substituted aryl or fused aryl; and

stereochemistry is variable at the positions marked *,

R 1 is selected from H, alkyl, amino alkyl, alkoxy;

Q=H 2 , O, —OR 1 , —N(R 1 ) 2 , —OPO(OR 1 ) x , —PO(OR 1 ) x , —P(OR 1 ) x where x=1-2;

V=NR 1 , O, —OPO(OR 1 ) x , —PO(OR 1 ) x , —P(OR 1 ) x where x=1-2;

W=H 2 , O;

X, Y=independently selected from H, aryl, naphthyl for n=0;

X, Y=aliphatic CH 2 or aromatic CH for n≧1 and Z is selected from aliphatic CH 2 , aromatic CH, or heteroatom;

A=lower alkoxy, lower alkylthio, aryl, substituted aryl or fused aryl; and

stereochemistry is variable at the positions marked *,

R 1 is selected from H, alkyl, amino alkyl, alkoxy;

Q=H 2 , O, —OR 1 , —N(R 1 ) 2 , —OPO(OR 1 ) x , —PO(OR 1 ) x , —P(OR 1 ) x where x=1-2;

V=NR 1 , O, —OPO(OR 1 ) x , —PO(OR 1 ) x , —P(OR 1 ) x where x=1-2;

W=H 2 , O;

X, Y=independently selected from H, aryl, naphthyl for n=0;

X, Y=aliphatic CH 2 or aromatic CH for n≧1 and Z is selected from aliphatic CH 2 , aromatic CH, or heteroatom;

A=lower alkoxy, lower alkylthio, aryl, substituted aryl or fused aryl; and

stereochemistry is variable at the positions marked *,

R 1 is selected from H, alkyl, amino alkyl, alkoxy;

Q=H 2 , O, —OR 1 , —N(R 1 ) 2 , —OPO(OR 1 ) x , —PO(OR 1 ) x , —P(OR 1 ) x where x=1-2;

V=NR 1 , O, —OPO(OR 1 ) x , —PO(OR 1 ) x , —P(OR 1 ) x where x=1-2;

W=H 2 , O;

X, Y=independently selected from H, aryl, naphthyl for n=0;

X, Y=aliphatic CH 2 or aromatic CH for n≧1 and Z is selected from aliphatic CH 2 , aromatic CH, or heteroatom;

A=lower alkoxy, lower alkylthio, aryl, substituted aryl or fused aryl; and

stereochemistry is variable at the positions marked *; and

wherein the compound activates at least one of TRPV1, TRPV1, or TRPM8, or combinations thereof.

2 . The skin engaging member of claim 1 , wherein said cyclohexanecarboxamide derivative is at a level of from about 0.01% to about 25%, by weight of said skin engaging member.

3 . The skin engaging member of claim 1 , wherein said cyclohexanecarboxamide derivative comprises: a 5-methyl-2-(1-methylethyl)-N-(2-phenylethyl)-, (1R,2S,5R) structure with 2-amino-propanamide and a 5-methyl-2-(1-methylethyl)-N-(2-phenylethyl)-, (1R,2S,5R) structure with 2-amino-propanamide, and mixtures thereof.

4 . The skin engaging member of claim 1 , wherein the cyclohexanecarboxamide derivatives is selected from the group consisting of:

a. Cyclohexanecarboxamide N-[2-[(2-aminoethyl)amino]-4-(methylthio)phenyl]-5-methyl-2-(1-methylethyl)-(1R,2S,5R)-;

b. Cyclohexanecarboxamide N-[2-[[(2S)-2-amino-1-oxopropyl]amino]-4-methoxyphenyl]-5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-;

c. Cyclohexanecarboxamide, N-[1-(2-aminoethoxy)-2-naphthalenyl]-5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-;

d. Cyclohexanecarboxamide, N-[2-[[(2R)-2-amino-1-oxopropyl]amino]-2-phenylethyl]-5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-;

e. Cyclohexanecarboxamide, N-[2-(2-aminoethoxy)-2-phenylethyl]-5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-; and

f. A mixture thereof.

5 . The skin engaging member of claim 1 , further comprising a menthane carboxylic acid-N-(4-methoxyphenyl)-amide of formula:

6 . The skin engaging member of claim 3 , wherein said menthane carboxylic acid-N-(4-methoxyphenyl)-amide comprises a N-[4-(cyanomethyl)phenyl]-(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxamide.

7 . The skin engaging member of claim 1 , further comprising an optional cooling agent selected from the group consisting of: L-menthol; p-menthane-3,8-diol; Isopulegol; Menthoxypropane-1,2,-diol; Curcumin; Menthyl Lactate (such as Frescolat ML by Symrise); Gingerol; Icilin; Tea Tree Oil; Methyl Salicylate; Camphor, Peppermint Oil; N-Ethyl-p-menthane-3-carboxamide; Ethyl 3-(p-menthane-3-carboxamido)acetate; 2-Isopropyl-N,2,3-trimethylbutyramide; Menthone glycerol ketal, Menthone Glyerine Acetal; Coolact 10; and mixtures thereof.

8 . The skin engaging member of claim 1 , wherein said matrix comprises a water soluble polymer.

9 . The skin engaging member of claim 8 , wherein the water soluble polymer is selected from polyethylene oxide, polyvinyl pyrrolidone, polyacrylamide, polyhydroxymethacrylate, polyvinyl imidazoline, polyethylene glycol, polyvinyl alcohol, polyhydroxyethymethacrylate, silicone polymers, and mixtures thereof.

10 . The skin engaging member of claim 8 , wherein said level of water soluble polymer is at a level of from about 50% to about 100% by weight of said solid polymeric matrix.

11 . The skin engaging member of claim 1 , wherein said matrix further comprises a water insoluble polymer comprising at least one of: polyethylene, polypropylene, polystyrene, high impact polystyrene, butadiene styrene copolymer, polyacetal, acrylonitrile-butadiene styrene copolymer, ethylene vinyl acetate copolymer, and mixtures thereof.

12 . The skin engaging member of claim 11 , wherein said water insoluble polymer is present at a level of from about 5% to about 40% by weight of the skin engaging member.

13 . The skin engaging member of claim 1 , wherein said matrix further comprises a block copolymer selected from the group consisting of: a di-block copolymer, a tri-block copolymer, a multi-block copolymer, a radial block copolymer, a random block copolymer, and mixtures thereof.

14 . A hair removal device comprising:

a. a cartridge;

b. one or more elongated edges positioned on said cartridge; and

c. the skin engaging member of claim 1 positioned on said cartridge.

15 . A method of providing a sensation on skin comprising the steps of:

a. Contacting a portion of skin with a hair removal device comprising

i. a cartridge;

ii. one or more elongated edges positioned on said cartridge; and

iii. the skin engaging member of claim 1 positioned on said cartridge, such that said one or more elongated edges and said skin engaging member contact said portion of skin.

Assignments (2)
MERGER AND CHANGE OF NAME Recorded Sep 26, 2016
From: THE GILLETTE COMPANY; THE GILLETTE COMPANY LLC
To: THE GILLETTE COMPANY LLC
Reel/Frame 040145/0258 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2016
From: HAUGHT, JOHN CHRISTIAN; REILLY, MICHAEL; BRADFORD, VALERIE JEAN; WANG, XIANDONG
To: THE GILLETTE COMPANY
Reel/Frame 038635/0648 →