Method for providing a circuit for biological liquid and circuit obtained

1. A method comprising:

forming a circuit for routing biological liquid, the circuit comprising a press, a disposable bag, routing network connectors, and a routing network of pipes through which said routing of the liquid is conducted between said connectors, said forming being conducted by:

providing the disposable bag as two flexible films attached together by a seal delimiting a closed contour defined by the two films with each of said routing network connectors and an inflating connector opening respectively inside and outside of said closed contour;

providing the press as two shells, at least one of said shells comprising recessed channels; and

forming said pipes of said routing network between said films by clamping said bag between said shells and injecting a pneumatic inflating agent into said bag between said shells via said inflating connector, said bag and said press being configured such that at least one of said pipes has a contour of which at least one portion is delimited exclusively by cooperation with said press upon said inflating, the portion of the contour of each of the at least one pipe which is delimited exclusively by cooperation with the press comprising opposed contact zones between the films, said contact zones bordering each of said at least one pipe and being fluid-tight, and said injecting causing said pipes to each be formed into conformity with a respective one of said recessed channels so as to define said pipe contour,

wherein said bag remains clamped between said shells during use of the circuit for said routing of the biological liquid, and wherein said pipes of the routing network are not pre-formed in the bags prior to said forming such that said pipes are exclusively delimited within said bag by cooperation of said bag with said press during said use.

2. A method according to claim 1 , wherein said inflating connector is separate from said routing network connectors.

3. A method according to claim 1 , wherein the step of forming said pipes further comprises beginning the step of injecting said inflating agent before said clamping of said bag between said shells.

4. A method according to claim 3 , wherein the step of injecting said inflating agent is preceded by pre-closing said press while said bag is in immediate proximity to each of the two shells.

5. A method according to claim 2 , wherein the step of forming said pipes further comprises beginning the step of injecting said inflating agent before said clamping of said bag between said shells.

6. A method according to claim 5 , wherein the step of injecting said inflating agent is preceded by pre-closing said press while said bag is in immediate proximity to each of the two shells.

7. A method according to claim 1 , wherein said one or more recessed channels of each of said shells has a semi-circular cross-section.

8. A method according to claim 1 , wherein the press comprises actuators of pinch valves, and sensors of a physico-chemical value.

9. A method according to claim 8 , wherein the actuators each comprise a body attached to one of said shells and a moveable finger capable of adopting a retracted position and a working position projecting from a respective one of said recessed channels of said shell to which the actuator body is attached.

10. A method according to claim 9 , wherein each of the actuators enables one of said pipes to be pinched between said moveable finger and the shell to which the actuator is not attached so as to allow or prevent the passage of said liquid at that location.

11. A method according to claim 8 , wherein the sensors each comprise a body attached to one of said shells in register with said recessed channels thereof, a distal end of the body opening into each of the recessed channels.

12. A method according to claim 11 , wherein the physico-chemical value is a temperature or pressure which can be measured by contact of the distal end with a respective one of said pipes within a respective one of said recessed channels without the sensors contacting said fluid running through the respective pipe.

13. A method according to claim 1 , wherein said shells are each formed from stainless steel and are each of a generally parallelepiped shape.

14. A method according to claim 1 , wherein the seal delimiting the closed contour is formed at a periphery of the films.

15. A method according to claim 1 , further comprising providing obturating plugs on each of the routing network connectors and on the inflating connector and sterilizing the bag by gamma irradiation.

16. A method according to claim 1 , wherein said pneumatic inflating agent is compressed air purified through a hydrophobic filter.

17. A method according to claim 1 , wherein said recessed channels are bordered on each side thereof at said contact zones by a groove in which is accommodated a respective bead of a network of beads serving to apply said flexible films against each other along said pipes.

18. A method according to claim 1 , further comprising a filter enclosed within said disposable bag.

19. A method according to claim 1 , further comprising using said circuit to route said biological liquid.

20. A method according to claim 1 , wherein each of the two shells comprise said recessed channels, each of the recessed channels of the two shells being substantially semi-circular in cross-section, and each of the recessed channels of one of the two shells cooperating with a respective one of the recessed channels of the other of the two shells so as to define said contour for each of said pipes of which at least one portion of said pipes is delimited exclusively by cooperating with respective recessed channels of the two shells.

21. A method comprising:

forming a circuit for routing biological liquid, the circuit comprising a press, a disposable bag, routing network connectors, and a routing network of pipes through which said routing of the liquid is conducted between said connectors, said forming being conducted by:

providing the disposable bag as two flexible films attached together by a seal delimiting a closed contour defined by the two films with each of said routing network connectors and an inflating connector opening respectively inside and outside of said closed contour;

providing the press as two shells, at least one of said shells comprising recessed channels; and

forming said pipes of said routing network between said films by clamping said bag between said shells and injecting a pneumatic inflating agent into said bag between said shells via said inflating connector, said bag and said press being configured such that at least one of said pipes has a contour of which at least one portion is delimited exclusively by cooperation with said press upon said inflating, the portion of the contour of each of the at least one pipe which is delimited exclusively by cooperation with the press comprising opposed contact zones between the films, said contact zones bordering each of said at least one pipe and being fluid-tight, and said injecting causing said pipes to each be formed into conformity with a respective one of said recessed channels so as to define said pipe contour,

wherein said bag remains clamped between said shells during use of the circuit for said routing of the biological liquid, and wherein said recessed channels are bordered on each side thereof at said contact zones by a groove in which is accommodated a respective bead of a network of beads serving to apply said flexible films against each other along said pipes.

22. A method according to claim 21 , wherein said inflating connector is separate from said routing network connectors.

23. A method according to claim 21 , wherein the step of forming said pipes further comprises beginning the step of injecting said inflating agent before said clamping of said bag between said shells.

24. A method according to claim 23 , wherein the step of injecting said inflating agent is preceded by pre-closing said press while said bag is in immediate proximity to each of the two shells.

25. A method according to claim 22 , wherein the step of forming said pipes further comprises beginning the step of injecting said inflating agent before said clamping of said bag between said shells.

26. A method according to claim 25 , wherein the step of injecting said inflating agent is preceded by pre-closing said press while said bag is in immediate proximity to each of the two shells.

27. A method according to claim 21 , wherein said one or more recessed channels of each of said shells has a semi-circular cross-section.

28. A method according to claim 21 , wherein the press comprises actuators of pinch valves, and sensors of a physico-chemical value.

29. A method according to claim 28 , wherein the actuators each comprise a body attached to one of said shells and a moveable finger capable of adopting a retracted position and a working position projecting from a respective one of said recessed channels of said shell to which the actuator body is attached.

30. A method according to claim 29 , wherein each of the actuators enables one of said pipes to be pinched between said moveable finger and the shell to which the actuator is not attached so as to allow or prevent the passage of said liquid at that location.

31. A method according to claim 28 , wherein the sensors each comprise a body attached to one of said shells in register with said recessed channels thereof, a distal end of the body opening into each of the recessed channels.

32. A method according to claim 31 , wherein the physico-chemical value is a temperature or pressure which can be measured by contact of the distal end with a respective one of said pipes within a respective one of said recessed channels without the sensors contacting said fluid running through the respective pipe.

33. A method according to claim 21 , wherein said shells are each formed from stainless steel and are each of a generally parallelepiped shape.

34. A method according to claim 21 , wherein the seal delimiting the closed contour is formed at a periphery of the films.

35. A method according to claim 21 , further comprising providing obturating plugs on each of the routing network connectors and on the inflating connector and sterilizing the bag by gamma irradiation.

36. A method according to claim 21 , wherein said pneumatic inflating agent is compressed air purified through a hydrophobic filter.

37. A method according to claim 21 , wherein said pipes of the routing network are not pre-formed in the bags prior to said forming.

38. A method according to claim 21 , further comprising a filter enclosed within said disposable bag.

39. A method according to claim 21 , further comprising using said circuit to route said biological liquid.

40. A method according to claim 21 , wherein each of the two shells comprise said recessed channels, each of the recessed channels of the two shells being substantially semi-circular in cross-section, and each of the recessed channels of one of the two shells cooperating with a respective one of the recessed channels of the other of the two shells so as to define said contour for each of said pipes of which at least one portion of said pipes is delimited exclusively by cooperating with respective recessed channels of the two shells.