Anti-microbial and osteointegration nanotextured surfaces
Disclosed is a medical device having a substrate having an exposed surface and a texture over at least part of the exposed surface. The texture includes a plurality of nanofeatures that inhibit bacterial adhesion on the surface and that also inhibit bacterial growth on the surface and have a size range between about 0.01 nanometers and about 1,000 nanometers. The texture can include a plurality of nanofeatures applied thereto such that the texture has a first particle size at a first location, a second particle size at a second location, and a gradient of particle size from the first particle size to the second particle size between the first location and the second location.
1. A medical device comprising:
a substrate having an exposed surface; and
a texture over at least part of the exposed surface, the texture comprising a plurality of nanofeatures, the nanofeatures having a first size range over a first portion of the exposed surface that produces a first property and a second size range, different from the first size range, over a second portion of the exposed surface that produces a second property, different from the first property.
2. The medical device according to claim 1 , wherein the first property inhibits bacterial adhesion on the surface.
3. The medical device according to claim 2 , wherein the first range is between about 0.01 nanometers and about 1,000 nanometers.
4. The medical device according to claim 2 , wherein the second property enhances osteointegration of the texture.
5. The medical device according to claim 4 , wherein the second range is between about 15 nanometers and about 3 millimeters.
6. A medical device comprising:
a substrate having an exposed surface; and
a texture over at least part of the exposed surface, the texture comprising a plurality of nanofeatures applied to the exposed surface, the texture having a only first particle size at a first region, a second particle size, different from the first particle size, at a second region, and a gradient of particle size from the first particle size to the second particle size between the first region and the second region.
7. The medical device according to claim 6 , wherein the nanofeatures at the first region have a first shape, and wherein the nanofeatures at the second region have a second shape, different from the first shape.
8. The medical device according to claim 6 , wherein the nanofeatures at the first region have a first size range and wherein the nanofeatures at the second region have a second size range, different from the first size range.
9. The medical device according to claim 6 , wherein the first particle size is sized to enhance osteoconductivity and wherein the second particle size is sized to enhance anti-bacterial properties.