Compositions and methods with efficacy against spores and other organisms
Compositions and methods for the disinfection of surfaces are provided. The compositions include a C 1-6 alcohol, and a primary enhancer selected from biguanides. The disinfectant composition is characterized by a pH of no more than about 2.5. Broad spectrum efficacy is achieved, and synergistic activity is exhibited against C. difficile spores.
1. A acidified composition for inactivation of C. difficile spores, the acidified composition comprising:
at least 10 wt. % of a C 1-6 alcohol,
from 0.1 to 20 wt. % of a primary enhancer consisting of one or more chlorhexidine salts, and
one or more acids,
wherein the acidified composition has a pH of no more than 2.5.
2. The acidified composition of claim 1 , wherein the C 1-6 alcohol is selected from the group consisting of ethanol, isopropanol, and combinations thereof.
3. The acidified composition of claim 1 , wherein the acidified composition comprises at least 30 wt. % of the C 1-6 alcohol, based upon the total weight of the acidified composition.
4. The acidified composition of claim 1 , wherein the acidified composition comprises at least 50 wt. % of the C 1-6 alcohol, based upon the total weight of the acidified composition.
5. The acidified composition of claim 1 , wherein the acidified composition further comprises a secondary enhancer that is selected from the group consisting of amine-containing enhancers, α-aminoacids, salts of alkali metals, salts of alkaline earth metals, anionic surfactants, and combinations thereof.
6. The acidified composition of claim 1 , wherein the pH of the acidified composition is from 0.5 to 2.
7. The acidified composition of claim 1 , wherein the C 1-6 alcohol is selected from the group consisting of ethanol, isopropanol, and combinations thereof, and wherein the one or more chlorhexidine salts consists of chlorhexidine gluconate.
8. The acidified composition of claim 1 , wherein the acidified composition comprises from 60 to 78 wt. % of the C 1-6 alcohol, based upon the total weight of the acidified composition.
9. A method for inactivation of C. difficile spores comprising:
contacting the spores with an acidified disinfectant composition comprising:
at least 10 wt. % of a C 1-6 alcohol,
from 0.1 to 20 wt. % of a primary enhancer consisting of one or more chlorhexidine salts, and
one or more acids,
wherein the acidified disinfectant composition has a pH of less than 2.5.
10. The method of claim 9 , wherein the C 1-6 alcohol is selected from the group consisting of ethanol, isopropanol, and combinations thereof.
11. The method of claim 9 , wherein the acidified disinfectant composition comprises at least 50 wt. % of the C 1-6 alcohol, based upon the total weight of the acidified disinfectant composition.
12. The method of claim 9 , wherein the acidified disinfectant composition further comprises a secondary enhancer that is selected from the group consisting of amine-containing enhancers, α-aminoacids, salts of alkali metals, salts of alkaline earth metals, anionic surfactants, and combinations thereof.
13. The method of claim 9 , wherein the one or more chlorhexidine salts consists of chlorhexidine gluconate.
14. The method of claim 9 , wherein the acidified disinfectant composition further comprises a secondary enhancer selected from the group consisting of non-ionic surfactants, auxiliary antimicrobial agents, organic acids, oxidizing agents, and combinations thereof.