Preservative-free single dose inhaler system

1. An aerosolization system, comprising:

a housing comprising two lateral faces and a plurality of side walls extending between the two lateral faces, the housing defining a mouthpiece on one of the plurality of side walls and a liquid receptacle fluidly coupled to the mouthpiece, wherein the liquid receptacle defines an opening that extends through an exterior surface of one of the plurality of side walls of the housing at an inlet end of the opening and that is configured to receive a dosage of liquid from a tip of a container that is interfaced with the liquid receptacle such that at least a portion of the tip of the container is received within the liquid receptacle while a main body of the container remains external to the housing;

an aerosol generator disposed within the housing, wherein during use the aerosol generator aerosolizes the dosage of liquid as a user inhales, the aerosol generator comprises:

a membrane having a front face, a rear face, and a plurality of apertures that extend between the front face and the rear face, wherein the dosage of liquid is received onto the rear face of the membrane; and

a vibratable element configured to vibrate the membrane to aerosolize the dosage of liquid;

a flow sensor configured to detect fluid flow through the mouthpiece as a user inhales;

a first light configured to indicate that the dosage of liquid has been manually dispensed from the tip of the container into a receiving chamber within the housing while the main body of the container remains external to the housing;

a second light configured to indicate that the vibratable element has aerosolized the dosage of liquid and the entire dosage of liquid has been delivered to a user, wherein:

the first and second lights are on a flat surface of one of the plurality of side walls of the housing aligned with the mouthpiece;

delivery of the entire dosage comprises delivery of 98% or more of the liquid received onto the rear face of the membrane;

the inlet end of the opening is positioned between, and in general alignment with, the mouthpiece and the first and second lights, with the first light, second light, and the opening being positioned on a same one of the plurality of side walls and the first light and the second light being oriented such that the first light and the second light are visible to the user while the user inhales through the mouthpiece; and

a common plane that is generally parallel to the two lateral faces passes through each of the inlet end of the opening, an opening of the mouthpiece, and the first and second lights; and

a controller coupled to the flow sensor and to the aerosol generator, wherein the controller activates the aerosol generator in response to a signal from the flow sensor indicating fluid flow through the mouthpiece, and wherein during use the controller activates the first light once the dosage of liquid is within the receiving chamber and the second light once the dosage of liquid is aerosolized and inhaled by the user.

2. The aerosolization system of claim 1 , wherein the first light blinks to indicate that the dosage of liquid is within the housing.

3. The aerosolization system of claim 1 , wherein the vibratable element vibrates the membrane from about 50 kHz to about 150 kHz.

4. The aerosolization system of claim 3 , wherein the second light blinks to indicate that the aerosol generator has aerosolized the dosage of liquid and the entire dosage of liquid has been delivered to the user.

5. The aerosolization system of claim 1 , wherein the liquid receptacle comprises a tapered wall that guides the dosage of liquid to the opening.

6. The aerosolization system of claim 5 , wherein the opening has an axis, and wherein the slope of the tapered wall is from 30 degrees to greater than perpendicular relative to the axis of the opening.

7. The aerosolization system of claim 1 , comprising a cover coupled to the housing, wherein the cover is configured to open and close to expose and cover the opening in the liquid receptacle.

8. The aerosolization system of claim 1 , wherein the liquid receptacle has a maximum receptacle diameter between about 10 mm to about 15 mm, and wherein the opening has a diameter of at least 5 mm.

9. The aerosolization system of claim 1 , comprises a bottle containing one or more dosages of liquid, and wherein the bottle is configured to dispense the dosage of liquid when the bottle is actuated.

10. An aerosolization system, comprising:

a housing comprising two lateral faces and a plurality of side walls extending between the two lateral faces, the housing defining a mouthpiece on one of the plurality of side walls and a liquid receptacle fluidly coupled to the mouthpiece, wherein the liquid receptacle defines an opening that extends through an exterior surface of one of the plurality of side walls of the housing at an inlet end of the opening and that is configured to receive a dosage of liquid from a tip of a container that is interfaced with the liquid receptacle such that at least a portion of the tip of the container is received within the liquid receptacle while a main body of the container remains external to the housing;

an aerosol generator disposed within the housing, wherein the aerosol generator comprises:

a membrane having a front face, a rear face, and a plurality of apertures that extend between the front face and the rear face, wherein the dosage of liquid is received onto the rear face of the membrane; and

a vibratable element configured to vibrate the membrane to aerosolize the dosage of liquid;

a first light configured to indicate that the dosage of liquid has been received within the housing from the tip of the container into a receiving chamber within the housing while the main body of the container remains external to the housing;

a second light configured to indicate that the dosage of liquid has been aerosolized and that the entire dosage of liquid has been delivered to a user, wherein:

the first and second lights are on a flat surface of one of the plurality of side walls of the housing aligned with the mouthpiece;

delivery of the entire dosage comprises delivery of 98% or more of the liquid received onto the rear face of the membrane;

the inlet end of the opening is positioned between, and in general alignment with, the mouthpiece and the first and second lights, with the first light, second light, and the opening being positioned on a same one of the plurality of side walls and the first light and the second light being oriented such that the first light and the second light are visible to the user while the user inhales through the mouthpiece; and

a common plane that is generally parallel to the two lateral faces passes through each of the inlet end of the opening, an opening of the mouthpiece, and the first and second lights; and

a controller coupled to the first light, wherein during use the controller activates the first light once the dosage of liquid is within the housing, and the second light when the entire dosage of liquid has been delivered to the user.

11. The aerosolization system of claim 10 , comprising a flow sensor coupled to the controller and configured to detect fluid flow through the mouthpiece as a user inhales, wherein the controller activates the aerosol generator in response to a signal from the flow sensor indicating fluid flow through the mouthpiece, wherein during use the vibratable element aerosolizes the dosage of liquid as the user inhales.

12. The aerosolization system of claim 10 , wherein the liquid receptacle comprises a tapered wall that guides the dosage of liquid to the opening.

13. The aerosolization system of claim 10 , comprises a bottle containing one or more dosages of liquid, and wherein the bottle is configured to dispense the dosage of liquid when the bottle is actuated.

14. An aerosolization system, comprising:

a housing comprising two lateral faces and a plurality of side walls extending between the two lateral faces, the housing defining a mouthpiece on one of the plurality of side walls and a liquid receptacle fluidly coupled to the mouthpiece, wherein the liquid receptacle defines an opening that extends through an exterior surface of one of the plurality of side walls of the housing at an inlet end of the opening and that is configured to receive a dosage of liquid from a tip of a container that is interfaced with the liquid receptacle such that at least a portion of the tip of the container is received within the liquid receptacle while a main body of the container remains external to the housing;

an aerosol generator disposed within the housing, wherein the aerosol generator comprises:

a membrane having a front face, a rear face, and a plurality of apertures that extend between the front face and the rear face, wherein the dosage of liquid is received onto the rear face of the membrane; and

a vibratable element configured to vibrate the membrane to aerosolize the dosage of liquid;

a first light configured to indicate that the dosage of liquid has been manually dispensed from the tip of the container into a receiving chamber within the housing while the main body of the container remains external to the housing;

a second light configured to indicate that the vibratable element has aerosolized the dosage of liquid and the entire dosage of liquid has been delivered to a user, wherein:

the first and second lights are on a flat surface of one of the plurality of side walls of the housing aligned with the mouthpiece;

delivery of the entire dosage comprises delivery of 99% or more of the liquid received onto the rear face of the membrane;

the inlet end of the opening is positioned between, and in general alignment with, the mouthpiece and the first and second lights, with the first light, second light, and the opening being positioned on a same one of the plurality of side walls and the first light and the second light being oriented such that the first light and the second light are visible to the user while the user inhales through the mouthpiece; and

a common plane that is generally parallel to the two lateral faces passes through each of the inlet end of the opening, an opening of the mouthpiece, and the first and second lights; and

a controller coupled to the first light and the second light, wherein during use the controller activates the first light once the dosage of liquid is within the receiving chamber and the second light after the vibratable element has aerosolized the dosage of liquid and the entire dosage of liquid has been delivered to the user.

15. The aerosolization system of claim 14 , comprising a flow sensor coupled to the controller and configured to detect fluid flow through the mouthpiece as a user inhales, wherein the controller activates the aerosol generator in response to a signal from the flow sensor indicating fluid flow through the mouthpiece, wherein during use the vibratable element aerosolizes the dosage of liquid as the user inhales.

16. The aerosolization system of claim 14 , wherein the liquid receptacle comprises a tapered wall that guides the dosage of liquid to the opening.

17. The aerosolization system of claim 14 , comprises a bottle containing one or more dosages of liquid, and wherein the bottle is configured to dispense the dosage of liquid when the bottle is actuated.