IP Library Granted Patent US 10,226,380
Granted Patent B2
US 10,226,380 · App. 15/165,759 · Granted Mar 12, 2019

Ocular pressure regulation

Inventor: Minas Theodore Coroneo (Menlo Park, CA)
Assignee: Novartis AG
A61F9/00781A61F2/148
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Quick Facts
Patent No.
US 10,226,380
App. No.
15/165,759
Granted
Mar 12, 2019
Kind
B2
Abstract

Disclosed are devices and methods of treating an ocular disorder including forming a self-sealing incision in a cornea into an anterior chamber of an eye; introducing through the incision a fluid drainage tube having a distal end, a proximal end and a longitudinal, internal lumen extending through the fluid drainage tube, wherein at least the proximal end passes through the anterior chamber; and implanting the distal end of the fluid drainage tube in fluid communication with the suprachoroidal space such that the proximal end of the fluid drainage tube remains in fluid communication with the anterior chamber.

Claims (25)

1. A method of treating an ocular disorder, comprising:

providing an implant having a distal end, a proximal end and a longitudinal, internal lumen extending through the ophthalmic implant and wherein the distal end of the implant includes a round, foldable plate adapted to locate the device on the inner surface of a sclera of the eye;

rolling up at least a portion of the implant to form a rolled up implant;

introducing the rolled up implant into a cannula;

forming an opening in a cornea into the anterior chamber of an eye;

filling the anterior chamber with a viscoelastic substance;

introducing the implant via the cannula through the opening, wherein at least the proximal end of the implant passes through the anterior chamber;

forming previously non-existing space in the eye by separating at least a portion of the ciliary body from at least a portion of the sclera from within the anterior chamber to form the space;

implanting the distal end of the implant in communication with the space; and

permitting aqueous humour to flow through the internal lumen from the anterior chamber towards the space.

2. A method as in claim 1 , wherein the implant comprises a tube.

3. A method as in claim 1 , wherein the space comprises at least a portion of the suprachoroidal space.

4. A method as in claim 1 , wherein forming a previously non-existing space in the eye comprises performing a cyclodialysis.

5. A method as in claim 4 , further comprising inserting viscoelastic to further form the space.

6. A method as in claim 5 , wherein inserting the viscoelastic comprises inserting viscoelastic through an attachment between the ciliary body and the sclera.

7. A method as in claim 6 , wherein inserting the viscoelastic comprises enlarging an area of detachment of the ciliary body from the sclera.

8. A method as in claim 7 , wherein the space extends into the suprachoroidal space.

9. A method as in claim 1 , wherein the proximal end of the implant remains in fluid communication with the anterior chamber.

10. A method as in claim 1 , wherein introducing through the opening an ophthalmic implant comprises introducing the entire ophthalmic implant into the anterior chamber of the eye.

11. A method as in claim 10 , wherein introducing the entire ophthalmic implant into the anterior chamber of the eye comprises passing the distal end and the proximal end of the ophthalmic implant through the cornea.

12. A method as in claim 1 , wherein introducing through the incision an ophthalmic implant comprises placing the ophthalmic implant in the eye after forming the space.

13. A method as in claim 1 , wherein forming an opening comprises creating a self-sealing incision in the cornea 180 degrees away from a planned insertion site of the ophthalmic implant in the eye.

14. A method as in claim 1 , wherein the incision is formed in the limbus of the cornea.

15. A method as in claim 1 , further comprising injecting a viscoelastic substance into the anterior chamber of the eye prior to introducing the ophthalmic implant through the opening.

16. A method as in claim 1 , wherein aqueous pressure of the eye is maintained at a pressure of not less than 10 mmHg.

Assignments (3)
CONFIRMATORY DEED OF ASSIGNMENT EFFECTIVE APRIL 8, 2019 Recorded Dec 10, 2019
From: NOVARTIS AG
To: ALCON INC.
Reel/Frame 051454/0788 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 19, 2016
From: TRANSCEND MEDICAL, INC.
To: NOVARTIS AG
Reel/Frame 039184/0905 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 17, 2016
From: CORONEO, MINAS THEODORE
To: TRANSCEND MEDICAL, INC.
Reel/Frame 038939/0412 →
Continuity (5)
Continuation 14199737 · Mar 6, 2014
Continuation 12905003 · Oct 14, 2010
Continuation 11615642 · Dec 22, 2006
Continuation 10712277 · Nov 14, 2003
Related Publication 20160346125A1 · Dec 1, 2016