Cross-sensitivity-compensated biosensor
Embodiments of the invention include a biosensor, such as an implantable biosensor, that includes a sensor material sensitive to at least one analyte in a pressure measurement chamber coupled to a pressure sensor. In embodiments of the invention, a pressure prevailing in the pressure measurement chamber may be determined by the pressure sensor. The sensor material is coupled in the pressure measurement chamber to a compensation material, which includes a relationship between a temperature and a volume of the pressure. The relationship is opposite to a temperature-dependent change in pressure or volume of the sensor material and at least partially compensates for a cross-sensitivity-induced change in volume of the sensor material.
1. A biosensor ( 10 ) comprising:
a sensor material ( 60 );
a pressure measurement chamber ( 20 );
a pressure sensor ( 56 ); and
a compensation material ( 70 );
wherein said sensor material ( 60 ) is sensitive to at least one analyte;
wherein said sensor material ( 60 ) is in the pressure measurement chamber ( 20 ),
wherein said compensation material ( 70 ) is in the pressure measurement chamber ( 20 ),
wherein said pressure measurement chamber ( 2 ) is ( 20 ) is coupled to the pressure sensor ( 56 ),
wherein a pressure prevailing in the pressure measurement chamber ( 20 ) is determined by the pressure sensor ( 56 ),
wherein the sensor material ( 60 ) is configured to undergo a change in volume in response to a cross-sensitivity of the sensor material ( 60 ) comprising a change to at least one ambient variable detected at said sensor material ( 60 ),
wherein the compensation material ( 70 ) is configured to undergo a change in volume in response to a change to the at least one ambient variable, and
wherein the change in volume of thr compensation material ( 70 ) is opposite to the change in volume of the sensor material ( 60 ),
such that the change in volume of the sensor material ( 60 ) is at least partially compensated for by the change in volume of the compensation material ( 70 ).
2. The biosensor according to claim 1 , wherein the cross-sensitivity-induced change in volume of the sensor material ( 60 ) is one or more of a temperature-induced change in volume and a pH value-induced change in volume.
3. The biosensor according to claim 1 , wherein the sensor material ( 60 ) sensitive to at least one analyte is a polymer gel, or hydrogel, or a smart hydrogel sensitive to at least one analyte.
4. The biosensor according to claim 1 , wherein said at least one ambient variable detected at said sensor material ( 60 ) comprises one or more of a change to a pH value, temperature change, and change in concentration of the at least one analyte.
5. The biosensor according to claim 1 , wherein the pressure measurement chamber ( 20 ) comprises at least two compartments ( 22 , 24 ), wherein the sensor material ( 60 ) is arranged in a first compartment of the at least two compartments and the compensation material ( 70 ) is arranged in a second compartment of the at least two compartments, and wherein the first compartment comprises a region ( 30 ) which is permeable to the at least one analyte and a test medium.
6. The biosensor according to claim 5 , wherein
the first compartment and the second compartment border one another, or
the biosensor further comprises a flexible membrane ( 40 ) arranged between the first compartment and the second compartment, or
both wherein the first compartment and the second compartment border one another and wherein the biosensor further comprises a flexible membrane ( 40 ) arranged between the first compartment and the second compartment.
7. The biosensor according to claim 6 , wherein said second compartment comprises a region which is permeable to the at least one analyte and the test medium.
8. The biosensor according to claim 5 , wherein the pressure sensor ( 56 ) is arranged at least in part in the second compartment and wherein regions of the pressure sensor ( 56 ) are surrounded by the compensation material ( 70 ).
9. The biosensor according to claim 8 , wherein the compensation material ( 70 ) is oil ( 72 ).
10. The biosensor according to claim 1 , wherein the pressure measurement chamber ( 20 ) comprises one compartment ( 26 ), wherein the sensor material ( 60 ) is mixed in the pressure measurement chamber ( 20 ) with the compensation material ( 70 ) within the one compartment ( 26 ), and wherein the one compartment ( 26 ) comprises a mechanical abutment which is permeable to the at least one analyte and a test medium.
11. The biosensor according to claim 10 , wherein the sensor material ( 60 ) together with the compensation material ( 70 ) form a stack arrangement comprising alternating layers of sensor material ( 60 ) and compensation material ( 70 ), or wherein the sensor material ( 60 ) together with the compensation material ( 70 ) comprise a mixture of particles of sensor material ( 60 ) and compensation material ( 70 ).
12. The biosensor according to claim 1 , wherein the pressure sensor ( 56 ) is arranged within the pressure measurement chamber ( 20 ) in an additional compartment ( 50 ), wherein the additional compartment ( 50 ) is filled with a pressure transfer medium ( 54 ).
13. The biosensor according to claim 5 , wherein the first compartment ( 22 ) is coupled to the second compartment ( 24 ) by a pressure piston connection ( 80 ) or by an extendable pipe connection ( 90 ), such that a change in volume of the first compartment ( 22 ) leads to a change in volume of the second compartment ( 24 ).
14. The biosensor according to claim 1 , wherein the compensation material ( 70 ) is a hydrogel.
15. The biosensor according to claim 1 , wherein the biosensor ( 10 ) is configured to be implanted in a human or animal body.
16. The biosensor according to claim 1 , wherein the pressure measurement chamber ( 20 ) comprises a wall, and wherein
the pressure sensor ( 56 ) is connected to the wall of the pressure measurement chamber ( 20 ), or
one or more components of the pressure sensor ( 56 ) are part of the wall of the pressure measurement chamber ( 20 ).