Granted Patent B2

US 9,775,911 · App. 15/170,827 · Granted Oct 3, 2017

Inventors: Michael D. Bentley (Huntsville, AL); Sean M. Culbertson (Gurley, AL); Samuel P. McManus (Guntersville, AL)

Assignee: Nektar Therapeutics

A61K47/48215A61K38/26A61K38/28C07C235/68C07D207/46C07K14/575C08G61/02C08G65/338C08G65/3348C08G65/33396C08G65/48C08K5/13A61K31/765C08K2201/012

Abstract

Claims (17)

1. A composition, comprising

(a) a polymeric reagent having the following structure:

wherein

POLY 1 is a first poly(alkylene glycol),

POLY 2 is a second poly(alkylene glycol),

X 1 is a first spacer moiety, and

X 2 is a second spacer moiety, and

(b) an antioxidant.

2. The composition of claim 1 , wherein each of POLY′ and POLY is a poly(ethylene glycol).

3. The composition of claim 2 , wherein each poly(ethylene glycol) has a weight-average molecular weight in the range of from about 120 Daltons to about 6,000 Daltons.

4. The composition of claim 2 , wherein each poly(ethylene glycol) has a weight-average molecular weight in the range of from about 6,000 Daltons to about 100,000 Daltons.

5. The composition of claim 1 , wherein the first spacer moiety is selected from the group consisting of —NH—C(O)—, —NH—C(O)—CH 2 —, —NH—C(O)—CH 2 —CH 2 —, —NH—C(O)—CH 2 —CH 2 —CH 2 —, —NH—C(O)—CH 2 —CH 2 —CH 2 —CH 2 —, —NH—C(O)—CH 2 —CH 2 —CH 2 —CH 2 —CH 2 —, —NH—C(O)—CH 2 —CH 2 —C(O)—, —NH—C(O)—CH 2 —CH 2 —CH 2 —C(O)—, —NH—C(O)—CH 2 —CH 2 —CH 2 —CH 2 —C(O)—, —NH—C(O)—CH 2 —CH 2 —CH 2 —CH 2 —CH 2 —C(O)—, —NH—CH 2 —CH 2 —(OCH 2 CH 2 ) 1-3 —NH—C(O)—, —NH—C(O)—CH 2 —O—, —NH—C(O)—CH 2 —CH 2 —CH 2 —C(O)—NH—CH 2 —CH 2 —, and —NH—C(O)—CH 2 —CH 2 —CH 2 —C(O)—NH—CH 2 —CH 2 —O—, and the second spacer moiety is selected from the group consisting of —NH—C(O)—, —NH—C(O)—CH 2 —, —NH—C(O)—CH 2 —CH 2 —, —NH—C(O)—CH 2 —CH 2 —CH 2 —, —NH—C(O)—CH 2 —CH 2 —CH 2 —CH 2 —, —NH—C(O)—CH 2 —CH 2 —CH 2 —CH 2 —CH 2 —, —NH—C(O)—CH 2 —CH 2 —C(O)—, —NH—C(O)—CH 2 —CH 2 —CH 2 —C(O)—, —NH—C(O)—CH 2 —CH 2 —CH 2 —CH 2 —C(O)—, —NH—C(O)—CH 2 —CH 2 —CH 2 —CH 2 —CH 2 —C(O)—, —NH—CH 2 —CH 2 —(OCH 2 CH 2 ) 1-3 —NH—C(O)—, —NH—C(O)—CH 2 —O—, —NH—C(O)—CH 2 —CH 2 —CH 2 —C(O)—NH—CH 2 —CH 2 —, and —NH—C(O)—CH 2 —CH 2 —CH 2 —C(O)—NH—CH 2 —CH 2 —O—.

6. The composition of claim 1 , wherein the polymeric reagent corresponds to the following formula:

wherein each (n) is from 4 to 1500.

7. The composition of claim 1 , wherein the polymeric reagent corresponds to the following formula:

wherein each (n) is from 4 to 1500.

8. The composition of claim 1 , wherein the antioxidant is butylated hydroxyl toluene.

Assignments (2)

Continuity (12)