Alternating sympathomimetic therapy for the treatment of respiratory ailments

1. A method of reducing side effects associated with the administration of pseudoephedrine in the alleviation of congestion, wherein the method comprises providing one or more first oral dosage units comprising pseudoephedrine and/or a pharmaceutically acceptable salt thereof and one or more second oral dosage units which are different from the one or more first dosage units and comprise phenylephrine and/or a pharmaceutically acceptable salt thereof for alternating ingestion of the first and second dosage units by a subject in need of alleviation of congestion.

2. The method of claim 1 , wherein at least one of the first and second dosage units at least one of (i) comprises an antihistamine, (ii) is free of an expectorant and (iii) is free of a cough suppressant.

3. The method of claim 2 , wherein at least one of the first and second dosage units comprises an antihistamine.

4. The method of claim 1 , wherein the first and second dosage units each independently further comprise at least one additional active ingredient selected from antihistamines, cough suppressants, expectorants, analgesics, anti-inflammatory agents.

5. The method of claim 1 , wherein the one or more second dosage units are free of pseudoephedrine and pharmaceutically acceptable salts thereof.

6. The method of claim 5 , wherein the one or more first dosage units are free of phenylephrine and pharmaceutically acceptable salts thereof.

7. The method of claim 1 , wherein the one or more first dosage units are provided for alleviating congestion during a period which substantially coincides with a period during which the subject intends to be awake and the one or more second dosage units are provided for alleviating congestion during a period which substantially coincides with a period during which the subject intends to be asleep.

8. The method of claim 1 , wherein the one or more first dosage units and the one or more second dosage units are provided in the form of a packaged combination of the first and second dosage units.

9. The method of claim 1 , wherein the first dosage unit comprises from about 90 mg to about 150 mg of pseudoephedrine hydrochloride or an equivalent amount of at least one of pseudoephedrine and any other pharmaceutically acceptable salt thereof.

10. The method of claim 1 , wherein the second dosage unit comprises from about 20 mg to about 40 mg of phenylephrine hydrochloride or an equivalent amount of at least one of phenylephrine and any other pharmaceutically acceptable salt thereof.

11. The method of claim 1 , wherein the first and second dosage units are independently provided in the form of tablets or capsules.

12. The method of claim 11 , wherein the first and second dosage units are provided as tablets.

13. The method of claim 1 , wherein at least the one or more second dosage units comprise a controlled release formulation.

14. The method of claim 1 , wherein at least one of the first and second dosage units is provided as a multilayered tablet.

15. The method of claim 14 , wherein the first and second dosage units both are provided as bilayered tablets.

16. The method of claim 14 , wherein the first dosage unit comprises a multilayered tablet comprising at least a first layer which is an immediate release layer and a second layer which is a controlled release layer.

17. The method of claim 16 , wherein the first layer of the first dosage unit comprises an antihistamine.

18. The method of claim 14 , wherein the second dosage unit comprises a multilayered tablet comprising at least a first layer which is an immediate release layer and a second layer which is a controlled release layer.