Crystalline forms of a histone deacetylase inhibitor
This disclosure provides solid forms of 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide, and methods of manufacturing and using these forms.
1. A crystalline form of 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide, wherein the crystalline form is characterized by an X-ray powder diffraction pattern having peaks expressed in degrees-2-theta at angles 8.3±0.2°, 10.6±0.2°, 16.6±0.2°, 21.3±0.2°, and 25.0±0.2°.
2. The crystalline form of claim 1 , wherein the crystalline form is characterized by a melting point at about 173° C.
3. The crystalline form of claim 1 , wherein the crystalline form is characterized by a melting point at 173 ±2° C.
4. A pharmaceutical composition comprising a crystalline form of 2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide, and a pharmaceutically acceptable carrier, wherein the crystalline form is characterized by an X-ray powder diffraction pattern having peaks expressed in degrees-2-theta at angles 8.3±0.2°, 10.6±0.2°, 16.6±0.2°, 21.3±0.2°, and 25.0±0.2°.