Acellular tissue matrix composition for tissue repair

1. A biocompatible implant composition, comprising: a polypropylene sheet substrate; and a biocompatible coating surrounding the sheet substrate, wherein the coating comprises a dried group of particulate acellular tissue matrix (ATM) particles, wherein the ATM particles comprise intact ATM swollen in an acidic solution having a pH of from about 1.0 to about 3.0 and that retains biological functions provided by undenatured collagenous proteins and non-collagenous molecules, wherein the instant ATM is swollen to a volume ranging from 1.8 to 12 times the initial volume of the ATM.

2. The implant composition of claim 1 , wherein the ATM comprises dermal ATM.

3. The implant composition of claim 1 , wherein the ATM comprises ATM derived from at least one of fascia, pericardial tissue, dura, umbilical cord tissue, placental tissue, cardiac valve tissue, ligament tissue, tendon tissue, arterial tissue, venous tissue, neural connective tissue, urinary bladder tissue, ureter tissue, and intestinal tissue.

4. The implant composition of claim 1 , wherein the ATM is derived from human tissue.

5. The implant composition of claim 1 , wherein the ATM is derived from non-human mammalian tissue.

6. The implant composition of claim 1 , wherein the non-human mammalian tissue is porcine.

7. The implant composition of claim 6 , wherein the tissue is from a non-human mammal that is genetically engineered to lack expression of α-1,3-galactosyl epitopes.

8. The implant composition of claim 7 , wherein the non-human mammal lacks a functional α-1,3-galactosyltransferase gene.

9. The implant composition of claim 1 , wherein the polypropylene sheet is a mesh.

10. The implant of claim 8 , wherein the polypropylene sheet comprises polypropylene monofilament.