Compounds and compositions as protein kinase inhibitors
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
1. A method for inhibiting B-Raf kinase activity in a B-Raf dependent cancer cell, the method comprising contacting the cell with a compound of the formula:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the B-Raf kinase is a mutant B-Raf kinase.
3. The method of claim 2 , wherein the mutant B-Raf kinase is B-Raf (V600E).
4. The method of claim 1 , which is carried out in vivo.
5. The method of claim 1 , wherein the cell is a melanoma cancer cell.
6. The method of claim 5 , wherein the melanoma is melanoma having a B-RAF V600E mutation.
7. The method of claim 5 , wherein the melanoma is metastatic melanoma.
8. The method of claim 7 , wherein the melanoma is melanoma having a B-RAF V600E mutation.
9. The method of claim 8 , which is carried out in vivo.